Download

Interaction data can be downloaded per organism or as complete datasets. All files are in CSV format. Large files may take a moment to prepare.

Interaction data by organism

Select an organism to download its complete interaction dataset including OG support, experimental count, and source dataset annotations.

Organism of interest

Min. direct evidence

OG support filter

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CSV columns:

gene_a, gene_b, target_organism, og6_supported, og7_supported,
      experimental_count, supporting_datasets, source_paralogs_raw

supporting_datasets — pipe-separated list of source dataset names · source_paralogs_raw — populated when paralog pooling occurred (format: OG_VERSION:DATASET_ID:SOURCE_GENE_A:SOURCE_GENE_B)

Source experimental interaction data

The four original PPI datasets used as the basis for orthology transfer.

Dataset	Organism	Edges	Format
T.brucei_2016_Gazestani	Trypanosoma brucei brucei TREU927	5,134	CSV	⬇ Download
T.brucei_2017_Crozier	Trypanosoma brucei brucei TREU927	1,650	CSV	⬇ Download
L.donovani_2025_Azimi	Leishmania donovani BPK282A1	15,991	CSV	⬇ Download
T.cruzi_2025_Azimi	Trypanosoma cruzi Sylvio X10/1-2012	16,076	CSV	⬇ Download

Complete database

All transferred interactions

All 1,535,794 interactions across all 20 organisms (~500 MB). Download may take several minutes.

⬇ Download full CSV

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Gene / protein list

All 176,431 genes across 20 organisms with OG6/OG7 annotations.

⬇ Download gene list

Academic use: If you use TrypsnetDB2 data in your research, please cite the original experimental studies and the TrypsnetDB2 resource. Contact us via the About page for details.