Trypanosomatid Protein Interaction Database

Orthology-transferred protein–protein interactions across 20 trypanosomatid organisms, derived from four co-fractionation/MS studies.

Examples: Tb927.9.3990 LdBPK_010430.1 LmxM.36.6320 TORC1 complex (5 genes)
1,535,794
Transferred interactions
176,431
Genes / proteins
20
Target organisms
38,821
Source PPI edges

Browse by organism

Crithidia
Crithidia fasciculata strain Cf-Cl
94,455 interactions
Leishmania
Leishmania aethiopica L147
91,219 interactions
Leishmania
Leishmania amazonensis MHOM/BR/71973/M2269
78,009 interactions
Leishmania
Leishmania braziliensis MHOM/BR/75/M2904
94,498 interactions
Leishmania
Leishmania donovani BPK282A1
61,665 interactions
Leishmania
Leishmania infantum JPCM5
91,177 interactions
Leishmania
Leishmania major strain Friedlin
93,123 interactions
Leishmania
Leishmania mexicana MHOM/GT/2001/U1103
93,048 interactions
Leishmania
Leishmania panamensis MHOM/COL/81/L13
89,435 interactions
Leishmania
Leishmania tropica L590
94,281 interactions
Leptomonas
Leptomonas pyrrhocoris H10
101,939 interactions
Trypanosoma
Trypanosoma brucei brucei TREU927
93,466 interactions
Trypanosoma
Trypanosoma congolense IL3000
100,998 interactions
Trypanosoma
Trypanosoma cruzi CL Brener Esmeraldo-like
78,734 interactions
Trypanosoma
Trypanosoma cruzi Dm28c 2018
127,446 interactions
Trypanosoma
Trypanosoma cruzi Sylvio X10/1-2012
56,960 interactions
Trypanosoma
Trypanosoma cruzi Y C6
92,130 interactions
Trypanosoma
Trypanosoma evansi strain STIB 805
82,136 interactions
Trypanosoma
Trypanosoma rangeli SC58
91,819 interactions
Trypanosoma
Trypanosoma vivax Y486
81,010 interactions

Source datasets

T.brucei_2016_Gazestani
Trypanosoma brucei brucei TREU927
5,134 edges
T.brucei_2017_Crozier
Trypanosoma brucei brucei TREU927
1,650 edges
L.donovani_2025_Azimi
Leishmania donovani BPK282A1
15,991 edges
T.cruzi_2025_Azimi
Trypanosoma cruzi Sylvio X10/1-2012
16,076 edges