TcCLB.504107.10

calpain-like cysteine peptidase, putative (fragment)

Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_115879 OG7: OG7_0021639 95 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 95 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcCLB.477983.10 ⚠ calpain cysteine peptidase, putative	—	OG6 LdBPK_270510.1 ↔ LdBPK_310410.1 OG6 TCSYLVIO_002993 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_002993 ↔ TCSYLVIO_007371	OG6
TcCLB.511329.10 ⚠ Calpain-like protein 2	—	OG6 LdBPK_270510.1 ↔ LdBPK_310410.1 OG6 TCSYLVIO_002993 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_002993 ↔ TCSYLVIO_007371	OG6
TcCLB.484311.10 ⚠ calpain-like cysteine peptidase, putative (fr	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007675 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_007371 ↔ TCSYLVIO_007676 +2 more	Both
TcCLB.511445.10 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007675 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_007371 ↔ TCSYLVIO_007676 +2 more	Both
TcCLB.506519.120 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_007675 ↔ TCSYLVIO_009032 OG7 TCSYLVIO_007675 ↔ TCSYLVIO_009032	Both
TcCLB.511441.10 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007675 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_007371 ↔ TCSYLVIO_007676 +2 more	Both
TcCLB.507105.80 ⚠ dispersed gene family protein 1 (DGF-1), puta	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG6 TCSYLVIO_007676 ↔ TCSYLVIO_009043 OG7 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG7 TCSYLVIO_007676 ↔ TCSYLVIO_009043	Both
TcCLB.503955.60 ⚠ Mitochondrial large ribosomal subunit mL49, p	—	OG6 TCSYLVIO_007675 ↔ TCSYLVIO_010573 OG7 TCSYLVIO_007675 ↔ TCSYLVIO_010573	Both
TcCLB.511171.10 ⚠ dispersed gene family protein 1 (DGF-1), puta	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG6 TCSYLVIO_007676 ↔ TCSYLVIO_009043	OG6
TcCLB.445281.9 ⚠ calpain-like cysteine peptidase, putative	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007675 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_007371 ↔ TCSYLVIO_007676 +2 more	Both
TcCLB.504241.90 ⚠ dispersed gene family protein 1 (DGF-1), puta	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG6 TCSYLVIO_007676 ↔ TCSYLVIO_009043	OG6
TcCLB.506869.40 ⚠ Mitochondrial large ribosomal subunit mL75, p	—	OG6 TCSYLVIO_007675 ↔ TCSYLVIO_009360 OG7 TCSYLVIO_007675 ↔ TCSYLVIO_009360	Both
TcCLB.507863.20 ⚠ dispersed gene family protein 1 (DGF-1), puta	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG6 TCSYLVIO_007676 ↔ TCSYLVIO_009043	OG6
TcCLB.511441.20 ⚠ calpain-like cysteine peptidase, putative (fr	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007675 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_007371 ↔ TCSYLVIO_007676 +2 more	Both
TcCLB.509777.80 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_007675 ↔ TCSYLVIO_010544 OG7 TCSYLVIO_007675 ↔ TCSYLVIO_010544	Both
TcCLB.511145.46 ⚠ 60S ribosomal protein L37a, putative	—	OG6 LdBPK_212190.1 ↔ LdBPK_270510.1 OG7 LdBPK_212190.1 ↔ LdBPK_270510.1	Both
TcCLB.507641.233 ⚠ ribosomal protein L37, putative	—	OG6 LdBPK_212190.1 ↔ LdBPK_270510.1 OG7 LdBPK_212190.1 ↔ LdBPK_270510.1	Both
TcCLB.509083.9 ⚠ ATP-dependent DEAD/H RNA helicase, putative	—	OG6 TCSYLVIO_006554 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_006554 ↔ TCSYLVIO_007675	Both
TcCLB.504153.150 ⚠ Unc104-like kinesin, putative	—	OG6 TCSYLVIO_005561 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_005561 ↔ TCSYLVIO_007371	OG6
TcCLB.506861.30 ⚠ 60S ribosomal protein L14, putative	—	OG6 LdBPK_221370.1 ↔ LdBPK_270510.1 OG7 LdBPK_221370.1 ↔ LdBPK_270510.1	Both
TcCLB.506937.30 ⚠ 60S ribosomal protein L14, putative	—	OG6 LdBPK_221370.1 ↔ LdBPK_270510.1 OG7 LdBPK_221370.1 ↔ LdBPK_270510.1	Both
TcCLB.506743.30 ⚠ 50S ribosomal protein L17, putative	—	OG6 TCSYLVIO_007654 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_007654 ↔ TCSYLVIO_007675	Both
TcCLB.507711.280 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004844 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_004844 ↔ TCSYLVIO_007675	Both
TcCLB.504149.140 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001604 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_001604 ↔ TCSYLVIO_007675	Both
TcCLB.508207.200 ⚠ small GTP-binding protein, putative	—	OG6 TCSYLVIO_002378 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_002378 ↔ TCSYLVIO_007675	Both
TcCLB.508127.9 ⚠ Mitochondrial large ribosomal subunit uL29m,	—	OG6 TCSYLVIO_007130 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_007130 ↔ TCSYLVIO_007675	Both
TcCLB.509151.80 ⚠ SpoU rRNA Methylase family, putative	—	OG7 TCSYLVIO_007498 ↔ TCSYLVIO_007675	OG7
TcCLB.510609.30 ⚠ GTPase, putative	—	OG7 TCSYLVIO_005645 ↔ TCSYLVIO_007675	OG7
TcCLB.510351.70 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_005645 ↔ TCSYLVIO_007675	OG7
TcCLB.506287.150 ⚠ GTP-binding protein, putative	—	OG7 TCSYLVIO_005645 ↔ TCSYLVIO_007675	OG7
TcCLB.504153.300 ⚠ GTPase protein, putative	—	OG7 TCSYLVIO_005645 ↔ TCSYLVIO_007675	OG7
TcCLB.507993.130 ⚠ 60S ribosomal protein L7, putative	—	OG7 LdBPK_260160.1 ↔ LdBPK_270510.1	OG7
TcCLB.509231.39 ⚠ zinc finger protein 3	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_007675	OG7
TcCLB.506739.99 ⚠ zinc finger (CCCH type) protein, putative	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_007675	OG7
TcCLB.504929.5 ⚠ zinc finger CCCH domain containing protein 11	—	OG7 TCSYLVIO_003384 ↔ TCSYLVIO_007675	OG7
TcCLB.510061.60 ⚠ dispersed gene family protein 1 (DGF-1), puta	—	OG7 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG7 TCSYLVIO_007676 ↔ TCSYLVIO_009043	OG7
TcCLB.508143.15 ⚠ dispersed gene family protein 1 (DGF-1), puta	—	OG7 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG7 TCSYLVIO_007676 ↔ TCSYLVIO_009043	OG7
TcCLB.511545.100 ⚠ RNA methyltransferase, putative	—	OG7 TCSYLVIO_007498 ↔ TCSYLVIO_007675	OG7
TcCLB.509667.10 ⚠ dispersed gene family protein 1 (DGF-1), puta	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG6 TCSYLVIO_007676 ↔ TCSYLVIO_009043	OG6
TcCLB.475705.9 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_000867 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_000867 ↔ TCSYLVIO_007371 OG7 TCSYLVIO_000867 ↔ TCSYLVIO_007676 OG7 TCSYLVIO_000867 ↔ TCSYLVIO_007371	Both
TcCLB.503629.10 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_000867 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_000867 ↔ TCSYLVIO_007371 OG7 TCSYLVIO_000867 ↔ TCSYLVIO_007676 OG7 TCSYLVIO_000867 ↔ TCSYLVIO_007371	Both
TcCLB.425851.9 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_000867 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_000867 ↔ TCSYLVIO_007371 OG7 TCSYLVIO_000867 ↔ TCSYLVIO_007676 OG7 TCSYLVIO_000867 ↔ TCSYLVIO_007371	Both
TcCLB.408573.9 ⚠ hypothetical protein, conserved (fragment)	—	OG6 TCSYLVIO_000867 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_000867 ↔ TCSYLVIO_007371 OG7 TCSYLVIO_000867 ↔ TCSYLVIO_007676 OG7 TCSYLVIO_000867 ↔ TCSYLVIO_007371	Both
TcCLB.420091.10 ⚠ dispersed gene family protein 1 (DGF-1), puta	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG6 TCSYLVIO_007676 ↔ TCSYLVIO_009043 OG7 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG7 TCSYLVIO_007676 ↔ TCSYLVIO_009043	Both
TcCLB.507795.100 ⚠ mitochondrial ribosomal protein L3, putative	—	OG6 TCSYLVIO_007675 ↔ TCSYLVIO_010727 OG7 TCSYLVIO_007675 ↔ TCSYLVIO_010727	Both
TcCLB.509013.10 ⚠ calpain-like cysteine peptidase, putative	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007675 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_007371 ↔ TCSYLVIO_007676 +2 more	Both
TcCLB.509013.19 ⚠ calpain-like cysteine peptidase, putative (fr	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007675 ↔ TCSYLVIO_007676 OG6 TCSYLVIO_007371 ↔ TCSYLVIO_007675 OG7 TCSYLVIO_007371 ↔ TCSYLVIO_007676 +2 more	Both
TcCLB.511123.40 ⚠ dispersed gene family protein 1 (DGF-1), puta	—	OG6 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG6 TCSYLVIO_007676 ↔ TCSYLVIO_009043 OG7 TCSYLVIO_007371 ↔ TCSYLVIO_009043 OG7 TCSYLVIO_007676 ↔ TCSYLVIO_009043	Both
TcCLB.511051.50 ⚠ 40S ribosomal protein S4, putative	—	OG6 LdBPK_131120.1 ↔ LdBPK_270510.1 OG7 LdBPK_131120.1 ↔ LdBPK_270510.1	Both
TcCLB.506739.150 ⚠ 60S ribosomal protein L13a, putative	—	OG6 LdBPK_270510.1 ↔ LdBPK_340910.1 OG7 LdBPK_270510.1 ↔ LdBPK_340910.1	Both

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