TcCLB.506211.210

mitogen-activated protein kinase kinase kinase, putative
Trypanosoma cruzi CL Brener Esmeraldo-like OG6: OG6_139852 OG7: OG7_0000432 13 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 13 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcCLB.508207.70 ⚠
Adenine phosphoribosyltransferase, putative
— OG6
TcCLB.508207.74 ⚠
Adenine phosphoribosyltransferase, putative
— OG6
TcCLB.482369.29
arginine kinase (fragment)
— OG6
TcCLB.506925.70
epsin, putative
— OG6
TcCLB.506945.20 ⚠
PAS-domain containing phosphoglycerate kinase
— OG6
TcCLB.506925.100
SCAMP family, putative
— OG6
TcCLB.511419.40 ⚠
phosphoglycerate kinase, putative
— OG6
TcCLB.506591.20
U-box domain protein, putative
— OG6
TcCLB.506529.508
glucose-6-phosphate isomerase, glycosomal, pu
— OG6
TcCLB.510507.20
3-ketoacyl-CoA thiolase, putative
— OG6
TcCLB.509979.150
nitrilase, putative
— OG6
TcCLB.511071.140
2-amino-3-ketobutyrate coenzyme A ligase, put
— OG6
TcCLB.506359.60
UTP-glucose-1-phosphate uridylyltransferase 2
— OG6
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.