LAEL147_000785000

Putative death-receptor fusion protein (DUF2428), putative
Leishmania aethiopica L147 OG6: OG6_146318 OG7: OG7_0006293 110 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 110 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAEL147_000246900 ⚠
ATPase family associated with various cellula
— OG7
LAEL147_000049400
hypothetical protein, conserved
— Both
LAEL147_000231200 ⚠
ubiquitin hydrolase, putative
— Both
LAEL147_000217900
protein phosphatase 2A regulatory subunit, pu
— Both
LAEL147_000657300 ⚠
chaperonin alpha subunit, putative
— +4 more Both
LAEL147_000023400 ⚠
Ring finger domain/Zn-finger in ubiquitin-hyd
— Both
LAEL147_000272800
Protein of unknown function (DUF3648), putati
— Both
LAEL147_000081200
hypothetical protein, conserved
— Both
LAEL147_000835500
hypothetical protein, conserved
— Both
LAEL147_000876100
hypothetical protein, conserved
— Both
LAEL147_000870500 ⚠
hypothetical protein, conserved
— Both
LAEL147_000871700
Rab3 GTPase-activating protein regulatory sub
— Both
LAEL147_000835300
hypothetical protein, conserved
— Both
LAEL147_000817700
hypothetical protein, conserved
— Both
LAEL147_000747800
coatomer alpha subunit, putative
— Both
LAEL147_000183400 ⚠
DNA-directed RNA polymerase I subunit, putati
— Both
LAEL147_000413600 ⚠
RNA-binding protein RBP10, putative
— Both
LAEL147_000543700
serine/threonine-protein kinase Nek3, putativ
— OG6
LAEL147_000073400
hypothetical protein, conserved
— Both
LAEL147_000583200 ⚠
protein mkt1, putative
— Both
LAEL147_000467800 ⚠
T-complex protein 1, beta subunit, putative
— +4 more Both
LAEL147_000559700 ⚠
ubiquitin hydrolase, putative
— OG7
LAEL147_000379900 ⚠
ubiquitin hydrolase, putative
— OG7
LAEL147_000315800 ⚠
Peptidase C19, ubiquitin carboxyl-terminal hy
— OG7
LAEL147_000243800 ⚠
WD domain, G-beta repeat, putative
— OG7
LAEL147_000883800 ⚠
replication factor C, subunit 5, putative
— OG7
LAEL147_000383700 ⚠
replication factor C, subunit 1, putative
— OG7
LAEL147_000574300 ⚠
replication factor C, subunit 2, putative
— OG7
LAEL147_000824800 ⚠
proteasome alpha 1 subunit, putative
— OG7
LAEL147_000320600 ⚠
Temperature dependent protein affecting M2 ds
— OG7
LAEL147_000600200 ⚠
'Cold-shock' DNA-binding domain containing pr
— OG7
LAEL147_000629100 ⚠
cyclin 9, putative
— OG7
LAEL147_000736400 ⚠
Zn-finger in ubiquitin-hydrolases and other p
— OG7
LAEL147_000807900 ⚠
leucine carboxyl methyltransferase, putative
— OG7
LAEL147_000745300 ⚠
ubiquitin hydrolase, putative
— OG7
LAEL147_000767200 ⚠
ubiquitin hydrolase, putative
— OG7
LAEL147_000723200 ⚠
eukaryotic translation initiation factor 2-al
— OG7
LAEL147_000189200 ⚠
chaperonin TCP20, putative
— +3 more OG7
LAEL147_000148500 ⚠
proteasome alpha 7 subunit, putative
— OG7
LAEL147_000193200 ⚠
proteasome alpha 3 subunit, putative
— OG7
LAEL147_000332400 ⚠
proteasome alpha 2 subunit, putative
— OG7
LAEL147_000006000 ⚠
proteasome alpha 7 subunit, putative
— OG7
LAEL147_000758900 ⚠
cell cycle sequence binding phosphoprotein (R
— OG7
LAEL147_000460100 ⚠
replication factor C, subunit 4, putative
— OG7
LAEL147_000783900 ⚠
replication factor C, subunit 3, putative
— OG7
LAEL147_000526900 ⚠
PSP1 C-terminal conserved region containing p
— OG7
LAEL147_000802200 ⚠
PSP1 C-terminal conserved region containing p
— OG7
LAEL147_000859200 ⚠
PSP1 C-terminal conserved region containing p
— OG7
LAEL147_000147400 ⚠
cell cycle sequence binding phosphoprotein (R
— OG7
LAEL147_000887500 ⚠
PSP1 C-terminal conserved region containing p
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.