LAMA_000577900

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase/DNA gyrase B/C-terminal associated domain of TOPRIM/DNA gyrase/topoisomerase IV, subunit A, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100284 OG7: OG7_0003182 17 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 17 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000136700 ⚠
Fingers domain of DNA polymerase lambda/DNA p
— Both
LAMA_000270300 ⚠
XRN 5'-3' exonuclease N-terminus/Xrn1 helical
— OG7
LAMA_000136600 ⚠
Helix-hairpin-helix domain/Fingers domain of
— OG7
LAMA_000063400 ⚠
DEAD/DEAH box helicase/Helicase conserved C-t
— Both
LAMA_000367100 ⚠
hypothetical protein, conserved
— Both
LAMA_000694800 ⚠
LysM domain containing protein, putative
— Both
LAMA_000096500 ⚠
Phosphoglucomutase/phosphomannomutase, alpha/
— Both
LAMA_000200900 ⚠
hypothetical protein, conserved
— Both
LAMA_000547700 ⚠
hypothetical protein, conserved
— Both
LAMA_000342600 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— OG6
LAMA_000052600 ⚠
hypothetical protein, conserved
— Both
LAMA_000078800 ⚠
hypothetical protein, conserved
— Both
LAMA_000324400 ⚠
XRN 5'-3' exonuclease N-terminus/Xrn1 helical
— Both
LAMA_000077700 ⚠
XRN 5'-3' exonuclease N-terminus/Xrn1 helical
— Both
LAMA_000447800 ⚠
hypothetical protein, conserved
— Both
LAMA_000264400 ⚠
hypothetical protein, conserved
— Both
LAMA_000260200 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— Both
Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.