LAMA_000260200

Pyridoxal-phosphate dependent enzyme, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100154 OG7: OG7_0002172 78 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 78 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000096500 ⚠
Phosphoglucomutase/phosphomannomutase, alpha/
— +2 more Both
LAMA_000547400 ⚠
CHAP domain/Glutathionylspermidine synthase p
— Both
LAMA_000440100 ⚠
AMP-binding enzyme/AMP-binding enzyme C-termi
— +1 more Both
LAMA_000510000 ⚠
Aspartate-ammonia ligase, putative
— Both
LAMA_000549400 ⚠
Ribonucleotide reductase, small chain, putati
— Both
LAMA_000398600 ⚠
Insulinase (Peptidase family M16), putative
— OG7
LAMA_000201300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000148500 ⚠
Uncharacterised protein family (UPF0160), put
— OG6
LAMA_000100500 ⚠
Inosine-uridine preferring nucleoside hydrola
— Both
LAMA_000213400 ⚠
Threonine synthase N terminus, putative
— Both
LAMA_000549700 ⚠
Amino-transferase class IV, putative
— Both
LAMA_000383500 ⚠
CTP synthase N-terminus/Glutamine amidotransf
— Both
LAMA_000549200 ⚠
Amino-transferase class IV, putative
— Both
LAMA_000743400 ⚠
Protein of unknown function (DUF3808), putati
— OG7
LAMA_000583700 ⚠
lactate/malate dehydrogenase, NAD binding dom
— Both
LAMA_000443600 ⚠
Thiolase, N-terminal domain/Beta-ketoacyl syn
— Both
LAMA_000055800 ⚠
Spermidine synthase tetramerisation domain/Sp
— Both
LAMA_000475600 ⚠
Hydroxymethylglutaryl-coenzyme A synthase N t
— Both
LAMA_000374200 ⚠
Metalloenzyme superfamily/BPG-independent PGA
— Both
LAMA_000598700 ⚠
Phosphomethylpyrimidine kinase/pfkB family ca
— Both
LAMA_000106000 ⚠
Peptidase M1 N-terminal domain/Peptidase fami
— Both
LAMA_000722400 ⚠
Peptidase M16 inactive domain containing prot
— Both
LAMA_000502300 ⚠
CHAP domain/Glutathionylspermidine synthase p
— OG7
LAMA_000537300
WD domain, G-beta repeat, putative
— OG7
LAMA_000351800 ⚠
Peptidase family M3, putative
— OG7
LAMA_000505400 ⚠
Peptidase M1 N-terminal domain/Peptidase fami
— OG7
LAMA_000760700 ⚠
Aminotransferase class I and II, putative
— OG7
LAMA_000192700 ⚠
Peptidase M1 N-terminal domain/Peptidase fami
— OG7
LAMA_000724600 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000724900 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000228100 ⚠
hypothetical protein, conserved
— OG7
LAMA_000771200 ⚠
Aminotransferase class I and II, putative
— OG7
LAMA_000572100 ⚠
16S rRNA methyltransferase RsmB/F, putative
— OG7
LAMA_000236800 ⚠
Cyclic nucleotide-binding domain/PAS fold/Pro
— OG7
LAMA_000694500 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000108400 ⚠
16S rRNA methyltransferase RsmB/F, putative
— OG7
LAMA_000521400 ⚠
Methyltransferase domain containing protein,
— OG7
LAMA_000493100 ⚠
PUA domain/16S rRNA methyltransferase RsmB/F,
— OG7
LAMA_000624900 ⚠
N-terminal domain of 16S rRNA methyltransfera
— OG7
LAMA_000752000 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000021200 ⚠
Hsp70 protein, putative
— OG6
LAMA_000280100 ⚠
Citrate synthase, C-terminal domain containin
— Both
LAMA_000710000 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG6
LAMA_000330400 ⚠
Aminotransferase class I and II, putative
— Both
LAMA_000303400 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG6
LAMA_000486000 ⚠
Protein phosphatase 2C, putative
— OG6
LAMA_000346000 ⚠
S-adenosyl-L-homocysteine hydrolase/S-adenosy
— Both
LAMA_000072200 ⚠
Rhodanese-like domain/Domain of unknown funct
— Both
LAMA_000342600 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— OG6
LAMA_000618900 ⚠
hypothetical protein, conserved
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.