LAMA_000072200

Rhodanese-like domain/Domain of unknown function (DUF1930), putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100692 OG7: OG7_0004631 131 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 131 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000537300
WD domain, G-beta repeat, putative
— Both
LAMA_000608100 ⚠
Leucine rich repeat, putative
— OG7
LAMA_000710000 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG6
LAMA_000719600
Polysaccharide biosynthesis protein/NAD depen
— Both
LAMA_000592200
Cytochrome b5-like Heme/Steroid binding domai
— OG6
LAMA_000289600
Glutamate-cysteine ligase, putative
— Both
LAMA_000221800
Enolase, N-terminal domain/Enolase, C-termina
— Both
LAMA_000195200 ⚠
Cyclic nucleotide-binding domain containing p
— Both
LAMA_000012300
Protein kinase domain/Protein tyrosine kinase
— OG6
LAMA_000722400 ⚠
Peptidase M16 inactive domain containing prot
— Both
LAMA_000047800
TatD related DNase, putative
— Both
LAMA_000064300
Iron only hydrogenase large subunit, C-termin
— Both
LAMA_000201300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000398600 ⚠
Insulinase (Peptidase family M16), putative
— OG7
LAMA_000720700 ⚠
Ferrous iron transport protein B/50S ribosome
— OG7
LAMA_000515300 ⚠
Ferrous iron transport protein B/50S ribosome
— OG7
LAMA_000818600 ⚠
50S ribosome-binding GTPase, putative
— OG7
LAMA_000066600 ⚠
NGP1NT (NUC091) domain/Ferrous iron transport
— OG7
LAMA_000665200 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LAMA_000815700 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000509300 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000554400 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000509400 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000784100 ⚠
Ubiquitin carboxyl-terminal hydrolase/ICP0-bi
— OG7
LAMA_000608200 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000174600 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000131800 ⚠
Isochorismatase family, putative
— OG7
LAMA_000162100 ⚠
Alcohol dehydrogenase GroES-like domain/Zinc-
— OG7
LAMA_000245300 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000437600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000260100 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000432300 ⚠
Mitochondrial glycoprotein, putative
— OG7
LAMA_000245400 ⚠
XRN 5'-3' exonuclease N-terminus, putative
— OG7
LAMA_000174400 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000276500 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000261200 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000332000 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000276600 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000167900 ⚠
Zinc finger, C3HC4 type (RING finger)/Prokary
— OG7
LAMA_000153000 ⚠
Zinc finger, C3HC4 type (RING finger) contain
— OG7
LAMA_000649300 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000237800 ⚠
Ubiquitin carboxyl-terminal hydrolase, putati
— OG7
LAMA_000752000 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000101200 ⚠
START domain containing protein, putative
— OG7
LAMA_000236800 ⚠
Cyclic nucleotide-binding domain/PAS fold/Pro
— OG7
LAMA_000694500 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000184300 ⚠
Isochorismatase family, putative
— OG7
LAMA_000310500 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000307500 ⚠
Elongation factor Tu GTP binding domain/Elong
— OG7
LAMA_000351800 ⚠
Peptidase family M3, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.