LAMA_000236800

Cyclic nucleotide-binding domain/PAS fold/Protein kinase domain/Protein tyrosine kinase/Kinase-like, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_156902 OG7: OG7_0001574 183 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 183 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000380900 ⚠
AAA domain (dynein-related subfamily)/Midasin
— Both
LAMA_000462200 ⚠
Axonemal dynein light chain, putative
— Both
LAMA_000090400 ⚠
HECT-domain (ubiquitin-transferase), putative
— Both
LAMA_000657400 ⚠
hypothetical protein, conserved
— Both
LAMA_000032500 ⚠
AMP-binding enzyme, putative
— OG7
LAMA_000218100
Kinesin motor domain/Microtubule binding, put
— OG6
LAMA_000244400
hypothetical protein, conserved
— OG6
LAMA_000055500 ⚠
Tetratricopeptide repeat, putative
— Both
LAMA_000784400
Proteasome complex subunit Rpn13 ubiquitin re
— OG6
LAMA_000209500
TCP-1/cpn60 chaperonin family, putative
— OG6
LAMA_000148100
Microtubule-binding stalk of dynein motor, pu
— OG6
LAMA_000035200 ⚠
Phosphatidylinositol 3- and 4-kinase, putativ
— Both
LAMA_000063900 ⚠
Fip1 motif/Zinc finger C-x8-C-x5-C-x3-H type
— Both
LAMA_000057000 ⚠
Axonemal dynein light chain, putative
— Both
LAMA_000530500
Proteasome subunit A N-terminal signature/Pro
— OG6
LAMA_000814900
Proteasome subunit A N-terminal signature/Pro
— OG6
LAMA_000292800
hypothetical protein, conserved
— OG6
LAMA_000203700 ⚠
hypothetical protein, conserved
— Both
LAMA_000219200 ⚠
hypothetical protein, conserved
— Both
LAMA_000189900 ⚠
Tetratricopeptide repeat, putative
— Both
LAMA_000688200
TCP-1/cpn60 chaperonin family, putative
— OG6
LAMA_000183700 ⚠
Initiation factor 2 subunit family, putative
— Both
LAMA_000153100 ⚠
ATPase family associated with various cellula
— Both
LAMA_000541800
TCP-1/cpn60 chaperonin family, putative
— OG6
LAMA_000222400 ⚠
hypothetical protein, conserved
— Both
LAMA_000172800
Proteasome subunit A N-terminal signature/Pro
— OG6
LAMA_000541200 ⚠
Initiation factor 2 subunit family, putative
— OG7
LAMA_000166000 ⚠
Initiation factor 2 subunit family, putative
— OG7
LAMA_000747800 ⚠
Guanine nucleotide exchange factor in Golgi t
— OG7
LAMA_000749000 ⚠
Guanine nucleotide exchange factor in Golgi t
— OG7
LAMA_000475100 ⚠
Transketolase, thiamine diphosphate binding d
— OG7
LAMA_000597100 ⚠
WW domain containing protein, putative
— OG7
LAMA_000595400 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LAMA_000253000 ⚠
WW domain containing protein, putative
— OG7
LAMA_000820400 ⚠
SPRY domain/HECT-domain (ubiquitin-transferas
— OG7
LAMA_000201300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000398600 ⚠
Insulinase (Peptidase family M16), putative
— OG7
LAMA_000722400 ⚠
Peptidase M16 inactive domain containing prot
— OG7
LAMA_000346000 ⚠
S-adenosyl-L-homocysteine hydrolase/S-adenosy
— OG7
LAMA_000749900 ⚠
TIP49 P-loop domain/DnaB-like helicase C term
— OG7
LAMA_000757900 ⚠
TIP49 P-loop domain/Holliday junction DNA hel
— OG7
LAMA_000096500 ⚠
Phosphoglucomutase/phosphomannomutase, alpha/
— OG7
LAMA_000330400 ⚠
Aminotransferase class I and II, putative
— OG7
LAMA_000416600 ⚠
DKCLD (NUC011) domain/TruB family pseudouridy
— OG7
LAMA_000719600 ⚠
Polysaccharide biosynthesis protein/NAD depen
— OG7
LAMA_000063800 ⚠
Biotin-requiring enzyme/e3 binding domain/2-o
— OG7
LAMA_000537300 ⚠
WD domain, G-beta repeat, putative
— OG7
LAMA_000260200 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— OG7
LAMA_000793100 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000395600 ⚠
Major Facilitator Superfamily, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.