LAMA_000032500

AMP-binding enzyme, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100746 OG7: OG7_0001203 49 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 49 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000724600 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000567600 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— Both
LAMA_000514000 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— Both
LAMA_000021200 ⚠
Hsp70 protein, putative
— Both
LAMA_000583300 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— OG6
LAMA_000213400 ⚠
Threonine synthase N terminus, putative
— Both
LAMA_000121100 ⚠
WD domain, G-beta repeat, putative
— Both
LAMA_000768100 ⚠
Pyruvate kinase, barrel domain/Pyruvate kinas
— Both
LAMA_000620700 ⚠
S-adenosylmethionine synthetase, N-terminal d
— Both
LAMA_000189200 ⚠
Phosphoglucose isomerase, putative
— Both
LAMA_000618000 ⚠
tRNA synthetases class I (E and Q), catalytic
— OG7
LAMA_000502300 ⚠
CHAP domain/Glutathionylspermidine synthase p
— OG7
LAMA_000724900 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000181200 ⚠
Cytochrome P450, putative
— Both
LAMA_000489100 ⚠
hypothetical protein, conserved
— OG7
LAMA_000720600 ⚠
Histidine kinase-, DNA gyrase B-, and HSP90-l
— OG7
LAMA_000120800 ⚠
Histidine kinase-, DNA gyrase B-, and HSP90-l
— OG7
LAMA_000757900 ⚠
TIP49 P-loop domain/Holliday junction DNA hel
— OG7
LAMA_000694500 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000236800 ⚠
Cyclic nucleotide-binding domain/PAS fold/Pro
— OG7
LAMA_000195200 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000031800 ⚠
Hsp70 protein, putative
— OG7
LAMA_000813600 ⚠
Hsp70 protein, putative
— OG7
LAMA_000510500 ⚠
Hsp70 protein, putative
— OG7
LAMA_000286500 ⚠
Hsp70 protein, putative
— OG7
LAMA_000538200 ⚠
Acyl-CoA dehydrogenase, N-terminal domain/Acy
— Both
LAMA_000547400 ⚠
CHAP domain/Glutathionylspermidine synthase p
— Both
LAMA_000615100 ⚠
Glyceraldehyde 3-phosphate dehydrogenase, NAD
— Both
LAMA_000475100 ⚠
Transketolase, thiamine diphosphate binding d
— Both
LAMA_000100500 ⚠
Inosine-uridine preferring nucleoside hydrola
— Both
LAMA_000492200 ⚠
ADP-ribosylation factor family/Ras of Complex
— Both
LAMA_000521200 ⚠
hypothetical protein, conserved
— OG6
LAMA_000749900 ⚠
TIP49 P-loop domain/DnaB-like helicase C term
— Both
LAMA_000416600 ⚠
DKCLD (NUC011) domain/TruB family pseudouridy
— Both
LAMA_000752000 ⚠
Cyclic nucleotide-binding domain containing p
— Both
LAMA_000063800 ⚠
Biotin-requiring enzyme/e3 binding domain/2-o
— Both
LAMA_000685500 ⚠
Leucine-rich repeat/Leucine Rich repeats (2 c
— Both
LAMA_000204500 ⚠
Adenylosuccinate synthetase, putative
— Both
LAMA_000288700 ⚠
Inosine-uridine preferring nucleoside hydrola
— Both
LAMA_000211300 ⚠
Inosine-uridine preferring nucleoside hydrola
— Both
LAMA_000239500 ⚠
tRNA synthetases class I (E and Q), catalytic
— Both
LAMA_000055800 ⚠
Spermidine synthase tetramerisation domain/Sp
— Both
LAMA_000722300 ⚠
Enoyl-CoA hydratase/isomerase/3-hydroxyacyl-C
— Both
LAMA_000517100 ⚠
Enoyl-CoA hydratase/isomerase/NAD binding dom
— Both
LAMA_000813900 ⚠
Glyceraldehyde 3-phosphate dehydrogenase, NAD
— Both
LAMA_000119300 ⚠
Amidohydrolase family, putative
— Both
LAMA_000549200 ⚠
Amino-transferase class IV, putative
— Both
LAMA_000549700 ⚠
Amino-transferase class IV, putative
— Both
LAMA_000517700 ⚠
Proline dehydrogenase, putative
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.