LAMA_000720600

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase/Hsp90 protein, putative

Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_103348 OG7: OG7_0001978 143 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 143 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAMA_000120800 ⚠ Histidine kinase-, DNA gyrase B-, and HSP90-l	—	OG7 LdBPK_290790.1 ↔ LdBPK_330360.1 OG7 TCSYLVIO_002205 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_008593 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_009151 ↔ TCSYLVIO_009400 +4 more	OG7
LAMA_000224000 ⚠ tRNA synthetases class I (W and Y), putative	—	OG7 TCSYLVIO_001244 ↔ TCSYLVIO_005578 OG7 LdBPK_161170.1 ↔ LdBPK_330360.1	OG7
LAMA_000448200 ⚠ Domain of unknown function (DUF1899)/Type of	—	OG7 Tb927.10.10960 ↔ Tb927.8.3100 OG7 TCSYLVIO_000174 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_000174 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_000174 ↔ TCSYLVIO_009151	OG7
LAMA_000132900 ⚠ WD domain, G-beta repeat, putative	—	OG7 Tb927.3.3580 ↔ Tb927.5.3260 OG7 TCSYLVIO_009151 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_009400 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_008621 ↔ TCSYLVIO_010560	OG7
LAMA_000422000 ⚠ Putative tRNA binding domain containing prote	—	OG6 TCSYLVIO_001244 ↔ TCSYLVIO_005578 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_005578 OG7 LdBPK_161170.1 ↔ LdBPK_330360.1	Both
LAMA_000252800 ⚠ Putative tRNA binding domain containing prote	—	OG6 TCSYLVIO_001244 ↔ TCSYLVIO_005578 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_005578 OG7 LdBPK_161170.1 ↔ LdBPK_330360.1	Both
LAMA_000278400 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_006181 ↔ TCSYLVIO_010666 OG7 Tb927.10.14030 ↔ Tb927.3.3580	OG7
LAMA_000236100 ⚠ Bacterial NAD-glutamate dehydrogenase/Glutama	—	OG7 LdBPK_151070.1 ↔ LdBPK_330360.1 OG7 TCSYLVIO_007064 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007064 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_007064 ↔ TCSYLVIO_009151 +1 more	OG7
LAMA_000293900 ⚠ Nucleosome assembly protein (NAP), putative	—	OG7 TCSYLVIO_007060 ↔ TCSYLVIO_008593 OG7 TCSYLVIO_007060 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007060 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_007060 ↔ TCSYLVIO_009151 +1 more	OG7
LAMA_000707800 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_330360.1 ↔ LdBPK_331280.1	OG7
LAMA_000766500 ⚠ Gar1/Naf1 RNA binding region containing prote	—	OG7 TCSYLVIO_003690 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_003690 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_003690 ↔ TCSYLVIO_009151	OG7
LAMA_000031800 ⚠ Hsp70 protein, putative	—	OG7 Tb927.3.3580 ↔ Tb927.9.9860 OG7 Tb927.11.7460 ↔ Tb927.3.3580	OG7
LAMA_000813600 ⚠ Hsp70 protein, putative	—	OG7 Tb927.3.3580 ↔ Tb927.9.9860 OG7 Tb927.11.7460 ↔ Tb927.3.3580	OG7
LAMA_000510500 ⚠ Hsp70 protein, putative	—	OG7 Tb927.3.3580 ↔ Tb927.9.9860 OG7 Tb927.11.7460 ↔ Tb927.3.3580	OG7
LAMA_000567600 ⚠ Hsp70 protein/MreB/Mbl protein, putative	—	OG7 Tb927.3.3580 ↔ Tb927.9.9860 OG7 Tb927.11.7460 ↔ Tb927.3.3580	OG7
LAMA_000514000 ⚠ Hsp70 protein/MreB/Mbl protein, putative	—	OG7 Tb927.3.3580 ↔ Tb927.9.9860 OG7 Tb927.11.7460 ↔ Tb927.3.3580	OG7
LAMA_000021200 ⚠ Hsp70 protein, putative	—	OG7 Tb927.3.3580 ↔ Tb927.9.9860 OG7 Tb927.11.7460 ↔ Tb927.3.3580	OG7
LAMA_000286500 ⚠ Hsp70 protein, putative	—	OG7 Tb927.3.3580 ↔ Tb927.9.9860 OG7 Tb927.11.7460 ↔ Tb927.3.3580	OG7
LAMA_000473300 ⚠ WD domain, G-beta repeat/PFU (PLAA family ubi	—	OG7 TCSYLVIO_001314 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_009151	OG7
LAMA_000185800 ⚠ Ubiquitin carboxyl-terminal hydrolase, putati	—	OG7 TCSYLVIO_005374 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005374 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005374 ↔ TCSYLVIO_009151	OG7
LAMA_000684300 ⚠ Ubiquitin carboxyl-terminal hydrolase, putati	—	OG7 TCSYLVIO_005374 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005374 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005374 ↔ TCSYLVIO_009151	OG7
LAMA_000790700 ⚠ Ubiquitin carboxyl-terminal hydrolase, putati	—	OG7 TCSYLVIO_005374 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005374 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005374 ↔ TCSYLVIO_009151	OG7
LAMA_000542000 ⚠ Ubiquitin carboxyl-terminal hydrolase, putati	—	OG7 TCSYLVIO_005374 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005374 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005374 ↔ TCSYLVIO_009151	OG7
LAMA_000747000 ⚠ Glutaminyl-tRNA synthetase, non-specific RNA	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005578	OG7
LAMA_000337200 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_009198 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_009151 ↔ TCSYLVIO_009198 OG7 TCSYLVIO_008621 ↔ TCSYLVIO_009198	OG7
LAMA_000670900 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_004135 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_004135 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_004135 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_002205 ↔ TCSYLVIO_004135	OG7
LAMA_000030200 ⚠ AMP-binding enzyme, putative	—	OG7 TCSYLVIO_003436 ↔ TCSYLVIO_010666	OG7
LAMA_000774200 ⚠ ATP synthase subunit D, putative	—	OG7 TCSYLVIO_005104 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005104 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005104 ↔ TCSYLVIO_009151	OG7
LAMA_000032500 ⚠ AMP-binding enzyme, putative	—	OG7 TCSYLVIO_003436 ↔ TCSYLVIO_010666	OG7
LAMA_000042700 ⚠ AMP-binding enzyme, putative	—	OG7 TCSYLVIO_003436 ↔ TCSYLVIO_010666	OG7
LAMA_000172400 ⚠ Inorganic pyrophosphatase, putative	—	OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_009151	OG7
LAMA_000049500 ⚠ Inorganic pyrophosphatase, putative	—	OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_009151	OG7
LAMA_000299400 ⚠ Phe-tRNA synthetase beta subunit B1 domain/B3	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_009151	OG7
LAMA_000673600 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_004111 ↔ TCSYLVIO_011092	OG7
LAMA_000662900 ⚠ PheRS DNA binding domain 1/PheRS DNA binding	—	OG7 TCSYLVIO_004213 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_004213 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_004213 ↔ TCSYLVIO_009151	OG7
LAMA_000158000 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_008446 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_008446 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_008446 ↔ TCSYLVIO_009151	OG7
LAMA_000147500 ⚠ Putative zinc finger in N-recognin (UBR box),	—	OG7 TCSYLVIO_006542 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_006542 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_006542 ↔ TCSYLVIO_009151	OG7
LAMA_000656400 ⚠ Histone chaperone Rttp106-like, putative	—	OG7 TCSYLVIO_006113 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_006113 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_006113 ↔ TCSYLVIO_009151	OG7
LAMA_000685500 ⚠ Leucine-rich repeat/Leucine Rich repeats (2 c	—	OG7 TCSYLVIO_005286 ↔ TCSYLVIO_010666	OG7
LAMA_000492200 ⚠ ADP-ribosylation factor family/Ras of Complex	—	OG7 TCSYLVIO_006267 ↔ TCSYLVIO_010666	OG7
LAMA_000416700 ⚠ ATP synthase, putative	—	OG7 TCSYLVIO_009151 ↔ TCSYLVIO_009375 OG7 TCSYLVIO_008621 ↔ TCSYLVIO_009375 OG7 TCSYLVIO_009375 ↔ TCSYLVIO_009400	OG7
LAMA_000063800 ⚠ Biotin-requiring enzyme/e3 binding domain/2-o	—	OG7 TCSYLVIO_009151 ↔ TCSYLVIO_009880 OG7 TCSYLVIO_009400 ↔ TCSYLVIO_009880 OG7 TCSYLVIO_008621 ↔ TCSYLVIO_009880	OG7
LAMA_000159500 ⚠ Exonuclease, putative	—	OG7 TCSYLVIO_009151 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_009400 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_008621 ↔ TCSYLVIO_010944	OG7
LAMA_000131000 ⚠ ThiF family/Ubiquitin/SUMO-activating enzyme	—	OG7 TCSYLVIO_009151 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_009400 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_008621 ↔ TCSYLVIO_010542	OG7
LAMA_000032800 ⚠ ThiF family, putative	—	OG7 TCSYLVIO_009151 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_009400 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_008621 ↔ TCSYLVIO_010542	OG7
LAMA_000542900 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_005512 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005512 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005512 ↔ TCSYLVIO_009151	OG7
LAMA_000270000 ⚠ 16S rRNA methyltransferase RsmB/F, putative	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_005578	OG7
LAMA_000284400 ⚠ 16S rRNA methyltransferase RsmB/F, putative	—	OG7 TCSYLVIO_004998 ↔ TCSYLVIO_005578	OG7
LAMA_000375400 ⚠ Adaptin N terminal region/HEAT repeats/non-SM	—	OG7 TCSYLVIO_004597 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_009151	OG7
LAMA_000474600 ⚠ Tubulin folding cofactor D C terminal, putati	—	OG7 TCSYLVIO_001302 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_009151	OG7

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