LAMA_000172400

Inorganic pyrophosphatase, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100346 OG7: OG7_0003350 277 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 277 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000032800 ⚠
ThiF family, putative
— OG7
LAMA_000590700 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— OG7
LAMA_000406400 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— OG7
LAMA_000389300 ⚠
hypothetical protein
— OG6
LAMA_000747000 ⚠
Glutaminyl-tRNA synthetase, non-specific RNA
— Both
LAMA_000389400 ⚠
Domain of unknown function (DUF1935)/Calpain
— OG6
LAMA_000435400 ⚠
MobA-like NTP transferase domain/Nucleotidyl
— Both
LAMA_000054400 ⚠
Domain of unknown function (DUF1935)/Calpain
— OG6
LAMA_000131000 ⚠
ThiF family/Ubiquitin/SUMO-activating enzyme
— Both
LAMA_000768100 ⚠
Pyruvate kinase, barrel domain/Pyruvate kinas
— Both
LAMA_000367500 ⚠
Rab-GTPase-TBC domain containing protein, put
— Both
LAMA_000553600 ⚠
Aldo/keto reductase family, putative
— OG7
LAMA_000136400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000692400 ⚠
Methyltransferase TYW3, putative
— OG7
LAMA_000626000 ⚠
Microtubule binding/Kinesin motor domain cont
— OG7
LAMA_000026100 ⚠
Kinesin motor domain/Microtubule binding, put
— OG7
LAMA_000209000 ⚠
Kinesin motor domain/Microtubule binding, put
— OG7
LAMA_000194900 ⚠
Kinesin motor domain/Microtubule binding/TRAF
— OG7
LAMA_000721900 ⚠
M17 aminopeptidase N-terminal domain 2/Cytoso
— OG7
LAMA_000474600 ⚠
Tubulin folding cofactor D C terminal, putati
— Both
LAMA_000224000 ⚠
tRNA synthetases class I (W and Y), putative
— Both
LAMA_000214300 ⚠
N-terminal conserved domain of Nudc./CS domai
— Both
LAMA_000342500 ⚠
Protein of unknown function (DUF2009), putati
— Both
LAMA_000223300 ⚠
Serine hydroxymethyltransferase, putative
— Both
LAMA_000273900 ⚠
GHMP kinases N terminal domain/Mevalonate 5-d
— Both
LAMA_000608600 ⚠
SET domain containing protein, putative
— Both
LAMA_000656400 ⚠
Histone chaperone Rttp106-like, putative
— Both
LAMA_000225700 ⚠
SLOG cluster4 family/Possible lysine decarbox
— Both
LAMA_000261200 ⚠
Dihydrouridine synthase (Dus), putative
— Both
LAMA_000222100 ⚠
YjeF-related protein N-terminus/Carbohydrate
— Both
LAMA_000083600 ⚠
SIS domain containing protein, putative
— Both
LAMA_000047900 ⚠
hypothetical protein, conserved
— Both
LAMA_000019200 ⚠
NPL4 family, putative
— Both
LAMA_000159500 ⚠
Exonuclease, putative
— Both
LAMA_000045900 ⚠
Alcohol dehydrogenase GroES-like domain/Zinc-
— Both
LAMA_000132900 ⚠
WD domain, G-beta repeat, putative
— Both
LAMA_000247200 ⚠
Amidohydrolase family, putative
— Both
LAMA_000096200 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— Both
LAMA_000532300 ⚠
hypothetical protein
— Both
LAMA_000112500 ⚠
XPC-binding domain/UBA/TS-N domain containing
— Both
LAMA_000292100 ⚠
Microtubule binding/Kinesin motor domain cont
— OG6
LAMA_000775500 ⚠
ApbE family/Alanine dehydrogenase/PNT, C-term
— Both
LAMA_000159700 ⚠
Isocitrate/isopropylmalate dehydrogenase, put
— Both
LAMA_000016200 ⚠
Dipeptidyl peptidase IV (DPP IV) N-terminal r
— Both
LAMA_000063800 ⚠
Biotin-requiring enzyme/e3 binding domain/2-o
— Both
LAMA_000147500 ⚠
Putative zinc finger in N-recognin (UBR box),
— Both
LAMA_000491700 ⚠
TAP42-like family, putative
— Both
LAMA_000479800 ⚠
Metallo-beta-lactamase superfamily domain/Cle
— Both
LAMA_000120600 ⚠
U-box domain containing protein, putative
— Both
LAMA_000498600 ⚠
hypothetical protein, conserved
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.