LAMA_000159700

Isocitrate/isopropylmalate dehydrogenase, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100639 OG7: OG7_0004251 164 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 164 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000194900 ⚠
Kinesin motor domain/Microtubule binding/TRAF
— OG7
LAMA_000663300
Alpha/beta hydrolase family/Serine aminopepti
— Both
LAMA_000498600
hypothetical protein, conserved
— Both
LAMA_000748800
Protein phosphatase 2C, putative
— OG6
LAMA_000761200
Phosphoglucomutase/phosphomannomutase, alpha/
— Both
LAMA_000306300 ⚠
Tetratricopeptide repeat, putative
— OG6
LAMA_000553400 ⚠
Tetratricopeptide repeat/Potential Monad-bind
— OG6
LAMA_000675300 ⚠
Cytidylyltransferase-like, putative
— Both
LAMA_000566200
WD domain, G-beta repeat, putative
— Both
LAMA_000275700 ⚠
Dephospho-CoA kinase, putative
— Both
LAMA_000311700 ⚠
Elongation factor Tu GTP binding domain/Elong
— Both
LAMA_000552400 ⚠
Protein phosphatase 2C, putative
— OG6
LAMA_000311100 ⚠
Protein phosphatase 2C, putative
— OG6
LAMA_000671000 ⚠
Protein phosphatase 2C, putative
— OG6
LAMA_000566500
Electron transfer flavoprotein domain/Electro
— Both
LAMA_000453000
Alanine racemase, N-terminal domain containin
— Both
LAMA_000420700
SEP domain containing protein, putative
— Both
LAMA_000575600
Telomere recombination/Putative GTP-binding c
— Both
LAMA_000005900
Cyclophilin type peptidyl-prolyl cis-trans is
— OG6
LAMA_000781600 ⚠
Phosphotransferase enzyme family/Choline/etha
— Both
LAMA_000351800 ⚠
Peptidase family M3, putative
— Both
LAMA_000383900 ⚠
hypothetical protein, conserved
— Both
LAMA_000395100 ⚠
hypothetical protein, conserved
— Both
LAMA_000655000
Myristoyl-CoA:protein N-myristoyltransferase,
— Both
LAMA_000606300
Iron-containing alcohol dehydrogenase, putati
— Both
LAMA_000247200
Amidohydrolase family, putative
— Both
LAMA_000624300
Ubiquitin family/Ubiquitin carboxyl-terminal
— Both
LAMA_000535800 ⚠
UBA/TS-N domain containing protein, putative
— Both
LAMA_000705000
Nicotinate phosphoribosyltransferase (NAPRTas
— Both
LAMA_000724400 ⚠
Transcription factor S-II (TFIIS), putative
— Both
LAMA_000172400 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000049500 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000133600
hypothetical protein, conserved
— Both
LAMA_000383500
CTP synthase N-terminus/Glutamine amidotransf
— Both
LAMA_000495100
hypothetical protein, conserved
— Both
LAMA_000283100
UTP--glucose-1-phosphate uridylyltransferase,
— Both
LAMA_000343500
NUDIX domain containing protein, putative
— Both
LAMA_000183800
PITH domain containing protein, putative
— Both
LAMA_000425600 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000108200 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000713100 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000040500 ⚠
Peptidase family M3, putative
— OG7
LAMA_000580200 ⚠
Eukaryotic initiation factor 4E, putative
— OG7
LAMA_000141900
AAA domain (dynein-related subfamily)/AAA dom
— OG7
LAMA_000759400 ⚠
pfkB family carbohydrate kinase, putative
— OG7
LAMA_000517300 ⚠
Peptidase family M3, putative
— OG7
LAMA_000595100 ⚠
pfkB family carbohydrate kinase, putative
— OG7
LAMA_000574300 ⚠
Elongation factor Tu GTP binding domain/Elong
— OG7
LAMA_000270300 ⚠
XRN 5'-3' exonuclease N-terminus/Xrn1 helical
— OG7
LAMA_000079800 ⚠
U-box domain containing protein, putative
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.