LAMA_000705000

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain/Nicotinate phosphoribosyltransferase (NAPRTase) family, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_109462 OG7: OG7_0015320 155 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 155 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000651000 ⚠
Aldo/keto reductase family, putative
— OG7
LAMA_000435900
Leucine Rich repeat, putative
— OG6
LAMA_000814100
Cyclophilin type peptidyl-prolyl cis-trans is
— OG6
LAMA_000553400 ⚠
Tetratricopeptide repeat/Potential Monad-bind
— OG6
LAMA_000768100
Pyruvate kinase, barrel domain/Pyruvate kinas
— Both
LAMA_000311700 ⚠
Elongation factor Tu GTP binding domain/Elong
— Both
LAMA_000655000
Myristoyl-CoA:protein N-myristoyltransferase,
— Both
LAMA_000535800 ⚠
UBA/TS-N domain containing protein, putative
— Both
LAMA_000314900
eIF-6 family, putative
— Both
LAMA_000633000
Biotin/lipoate A/B protein ligase family, put
— Both
LAMA_000779600 ⚠
Thioredoxin/Glutaredoxin, putative
— Both
LAMA_000120600 ⚠
U-box domain containing protein, putative
— Both
LAMA_000159700
Isocitrate/isopropylmalate dehydrogenase, put
— Both
LAMA_000432700
Dephospho-CoA kinase, putative
— OG6
LAMA_000491700
TAP42-like family, putative
— Both
LAMA_000808200 ⚠
Protein of unknown function (DUF2009), putati
— Both
LAMA_000498600
hypothetical protein, conserved
— Both
LAMA_000681300 ⚠
Iron/manganese superoxide dismutases, alpha-h
— Both
LAMA_000541700 ⚠
WD domain, G-beta repeat, putative
— Both
LAMA_000247200
Amidohydrolase family, putative
— Both
LAMA_000019200
NPL4 family, putative
— Both
LAMA_000222100
YjeF-related protein N-terminus/Carbohydrate
— Both
LAMA_000400500
hypothetical protein, conserved
— Both
LAMA_000273900
GHMP kinases N terminal domain/Mevalonate 5-d
— Both
LAMA_000342500 ⚠
Protein of unknown function (DUF2009), putati
— Both
LAMA_000065100 ⚠
Glutaredoxin, putative
— Both
LAMA_000555200
hypothetical protein, conserved
— Both
LAMA_000724400 ⚠
Transcription factor S-II (TFIIS), putative
— Both
LAMA_000450900
Ran-interacting Mog1 protein, putative
— Both
LAMA_000172400 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000049500 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000194900 ⚠
Kinesin motor domain/Microtubule binding/TRAF
— OG7
LAMA_000209000 ⚠
Kinesin motor domain/Microtubule binding, put
— OG7
LAMA_000026100 ⚠
Kinesin motor domain/Microtubule binding, put
— OG7
LAMA_000626000 ⚠
Microtubule binding/Kinesin motor domain cont
— OG7
LAMA_000136400
hypothetical protein, conserved
— OG7
LAMA_000686600 ⚠
Serine hydrolase (FSH1)/50S ribosome-binding
— OG7
LAMA_000547000 ⚠
50S ribosome-binding GTPase/Ferrous iron tran
— OG7
LAMA_000553600 ⚠
Aldo/keto reductase family, putative
— OG7
LAMA_000574900 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000515800 ⚠
MORN repeat/FYVE zinc finger containing prote
— OG7
LAMA_000713100 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000580200 ⚠
Eukaryotic initiation factor 4E, putative
— OG7
LAMA_000416400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000809200 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000079800 ⚠
U-box domain containing protein, putative
— OG7
LAMA_000590600 ⚠
Eukaryotic initiation factor 4E, putative
— OG7
LAMA_000298800 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000801700 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000421000 ⚠
Tetrahydrofolate dehydrogenase/cyclohydrolase
— OG7
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.