LAMA_000421000

Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain/Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_200158 OG7: OG7_0002739 136 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 136 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000498600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000731400 ⚠
CS domain containing protein, putative
— OG7
LAMA_000663300 ⚠
Alpha/beta hydrolase family/Serine aminopepti
— OG7
LAMA_000763300 ⚠
Adaptin N terminal region/Adaptin C-terminal
— OG7
LAMA_000734700 ⚠
Soluble NSF attachment protein, SNAP, putativ
— OG7
LAMA_000761200 ⚠
Phosphoglucomutase/phosphomannomutase, alpha/
— OG7
LAMA_000580200 ⚠
Eukaryotic initiation factor 4E, putative
— OG7
LAMA_000566800 ⚠
haloacid dehalogenase-like hydrolase/Sucrose-
— OG7
LAMA_000663900 ⚠
Ubiquitin-conjugating enzyme, putative
— OG7
LAMA_000650300 ⚠
KH domain/Domain of unknown function (DUF1771
— OG7
LAMA_000665300 ⚠
Importin-beta N-terminal domain/Exportin 1-li
— OG7
LAMA_000695600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000416400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000809200 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000768100 ⚠
Pyruvate kinase, barrel domain/Pyruvate kinas
— OG7
LAMA_000638400 ⚠
Tetrapyrrole (Corrin/Porphyrin) Methylases, p
— OG7
LAMA_000311700 ⚠
Elongation factor Tu GTP binding domain/Elong
— OG7
LAMA_000655000 ⚠
Myristoyl-CoA:protein N-myristoyltransferase,
— OG7
LAMA_000535800 ⚠
UBA/TS-N domain containing protein, putative
— OG7
LAMA_000314900 ⚠
eIF-6 family, putative
— OG7
LAMA_000633000 ⚠
Biotin/lipoate A/B protein ligase family, put
— OG7
LAMA_000678800 ⚠
hypothetical protein, conserved
— OG7
LAMA_000779600 ⚠
Thioredoxin/Glutaredoxin, putative
— OG7
LAMA_000718000 ⚠
hypothetical protein, conserved
— OG7
LAMA_000619700 ⚠
Dynein heavy chain region D6 P-loop domain co
— OG7
LAMA_000120600 ⚠
U-box domain containing protein, putative
— OG7
LAMA_000079800 ⚠
U-box domain containing protein, putative
— OG7
LAMA_000114700 ⚠
Choline/Carnitine o-acyltransferase, putative
— OG7
LAMA_000159700 ⚠
Isocitrate/isopropylmalate dehydrogenase, put
— OG7
LAMA_000590600 ⚠
Eukaryotic initiation factor 4E, putative
— OG7
LAMA_000569200 ⚠
Sucrose-6F-phosphate phosphohydrolase/haloaci
— OG7
LAMA_000324400 ⚠
XRN 5'-3' exonuclease N-terminus/Xrn1 helical
— OG7
LAMA_000575600 ⚠
Telomere recombination/Putative GTP-binding c
— OG7
LAMA_000298800 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000221900 ⚠
FYVE zinc finger/Ras family, putative
— OG7
LAMA_000270300 ⚠
XRN 5'-3' exonuclease N-terminus/Xrn1 helical
— OG7
LAMA_000026900 ⚠
Glutaredoxin, putative
— OG7
LAMA_000222100 ⚠
YjeF-related protein N-terminus/Carbohydrate
— OG7
LAMA_000275700 ⚠
Dephospho-CoA kinase, putative
— OG7
LAMA_000420600 ⚠
Choline/Carnitine o-acyltransferase, putative
— OG7
LAMA_000172400 ⚠
Inorganic pyrophosphatase, putative
— OG7
LAMA_000049500 ⚠
Inorganic pyrophosphatase, putative
— OG7
LAMA_000400500 ⚠
hypothetical protein, conserved
— OG7
LAMA_000087800 ⚠
Adaptin N terminal region containing protein,
— OG7
LAMA_000724400 ⚠
Transcription factor S-II (TFIIS), putative
— OG7
LAMA_000455700 ⚠
Transcription factor S-II (TFIIS), central do
— OG7
LAMA_000065100 ⚠
Glutaredoxin, putative
— OG7
LAMA_000396800 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000273900 ⚠
GHMP kinases N terminal domain/Mevalonate 5-d
— OG7
LAMA_000047900 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.