LAMA_000768100

Pyruvate kinase, barrel domain/Pyruvate kinase, alpha/beta domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100258 OG7: OG7_0002165 170 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 170 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000172400 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000049500 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000222100
YjeF-related protein N-terminus/Carbohydrate
— Both
LAMA_000209000 ⚠
Kinesin motor domain/Microtubule binding, put
— OG7
LAMA_000288700 ⚠
Inosine-uridine preferring nucleoside hydrola
— Both
LAMA_000211300 ⚠
Inosine-uridine preferring nucleoside hydrola
— Both
LAMA_000756700
Aldose 1-epimerase, putative
— Both
LAMA_000032500 ⚠
AMP-binding enzyme, putative
— Both
LAMA_000240000 ⚠
3'5'-cyclic nucleotide phosphodiesterase, put
— Both
LAMA_000615100 ⚠
Glyceraldehyde 3-phosphate dehydrogenase, NAD
— Both
LAMA_000778800 ⚠
ApbE family/Alanine dehydrogenase/PNT, C-term
— Both
LAMA_000389400 ⚠
Domain of unknown function (DUF1935)/Calpain
— OG6
LAMA_000240100 ⚠
hypothetical protein, conserved
— Both
LAMA_000240200 ⚠
3'5'-cyclic nucleotide phosphodiesterase, put
— Both
LAMA_000775500 ⚠
ApbE family/Alanine dehydrogenase/PNT, C-term
— Both
LAMA_000778900 ⚠
FAD dependent oxidoreductase/Pyridine nucleot
— Both
LAMA_000042700 ⚠
AMP-binding enzyme, putative
— Both
LAMA_000054400 ⚠
Domain of unknown function (DUF1935)/Calpain
— OG6
LAMA_000013500 ⚠
M17 aminopeptidase N-terminal domain 2, putat
— Both
LAMA_000096200 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— Both
LAMA_000475100
Transketolase, thiamine diphosphate binding d
— Both
LAMA_000813900 ⚠
Glyceraldehyde 3-phosphate dehydrogenase, NAD
— Both
LAMA_000016400
Dihydrofolate reductase/Thymidylate synthase,
— Both
LAMA_000204500
Adenylosuccinate synthetase, putative
— Both
LAMA_000761200
Phosphoglucomutase/phosphomannomutase, alpha/
— Both
LAMA_000675300 ⚠
Cytidylyltransferase-like, putative
— Both
LAMA_000566200
WD domain, G-beta repeat, putative
— Both
LAMA_000275700 ⚠
Dephospho-CoA kinase, putative
— Both
LAMA_000589700
Protein phosphatase 2C, putative
— OG6
LAMA_000566500
Electron transfer flavoprotein domain/Electro
— Both
LAMA_000453000
Alanine racemase, N-terminal domain containin
— Both
LAMA_000420700
SEP domain containing protein, putative
— Both
LAMA_000600000 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— Both
LAMA_000633600 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— Both
LAMA_000575600
Telomere recombination/Putative GTP-binding c
— Both
LAMA_000005900
Cyclophilin type peptidyl-prolyl cis-trans is
— OG6
LAMA_000655000
Myristoyl-CoA:protein N-myristoyltransferase,
— Both
LAMA_000624300
Ubiquitin family/Ubiquitin carboxyl-terminal
— Both
LAMA_000535800 ⚠
UBA/TS-N domain containing protein, putative
— Both
LAMA_000705000
Nicotinate phosphoribosyltransferase (NAPRTas
— Both
LAMA_000724400 ⚠
Transcription factor S-II (TFIIS), putative
— Both
LAMA_000189200
Phosphoglucose isomerase, putative
— Both
LAMA_000084900
DeoC/LacD family aldolase, putative
— Both
LAMA_000194900 ⚠
Kinesin motor domain/Microtubule binding/TRAF
— OG7
LAMA_000574300 ⚠
Elongation factor Tu GTP binding domain/Elong
— OG7
LAMA_000425600 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000108200 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000303800 ⚠
Eukaryotic initiation factor 4E, putative
— OG7
LAMA_000679400 ⚠
Cid1 family poly A polymerase, putative
— OG7
LAMA_000713100 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.