LAMA_000013500

M17 aminopeptidase N-terminal domain 2, putative

Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_142599 OG7: OG7_0003405 266 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 266 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAMA_000633600 ⚠ Peptidase family M20/M25/M40/Peptidase dimeri	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
LAMA_000600000 ⚠ Peptidase family M20/M25/M40/Peptidase dimeri	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
LAMA_000054400 ⚠ Domain of unknown function (DUF1935)/Calpain	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
LAMA_000347500 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_110630.1 ↔ LdBPK_364240.1 OG6 LdBPK_110640.1 ↔ LdBPK_364240.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008197 OG7 LdBPK_110630.1 ↔ LdBPK_364240.1 +2 more	Both
LAMA_000557900 ⚠ Rrp44-like cold shock domain/Dis3-like cold-s	—	OG6 LdBPK_110630.1 ↔ LdBPK_280470.1 OG6 LdBPK_110640.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 +2 more	Both
LAMA_000362600 ⚠ tRNA synthetases class I (I, L, M and V)/Anti	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
LAMA_000053300 ⚠ RNB domain containing protein, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
LAMA_000559100 ⚠ RNB domain containing protein, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
LAMA_000132900 ⚠ WD domain, G-beta repeat, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	Both
LAMA_000096200 ⚠ Pyridine nucleotide-disulphide oxidoreductase	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
LAMA_000778900 ⚠ FAD dependent oxidoreductase/Pyridine nucleot	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
LAMA_000775500 ⚠ ApbE family/Alanine dehydrogenase/PNT, C-term	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
LAMA_000590700 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
LAMA_000389400 ⚠ Domain of unknown function (DUF1935)/Calpain	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
LAMA_000778800 ⚠ ApbE family/Alanine dehydrogenase/PNT, C-term	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
LAMA_000593700 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG6 LdBPK_110630.1 ↔ LdBPK_300810.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG7 LdBPK_110630.1 ↔ LdBPK_300810.1	Both
LAMA_000406400 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
LAMA_000389300 ⚠ hypothetical protein	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
LAMA_000591800 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG6 LdBPK_110640.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	Both
LAMA_000031500 ⚠ Aspartyl protease/gag-polyprotein putative as	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003428 OG6 LdBPK_010630.1 ↔ LdBPK_110630.1 OG6 LdBPK_010630.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003428 +3 more	Both
LAMA_000747000 ⚠ Glutaminyl-tRNA synthetase, non-specific RNA	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG6 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 +1 more	Both
LAMA_000473100 ⚠ Cyclin/Cyclin, N-terminal domain containing p	—	OG7 LdBPK_110630.1 ↔ LdBPK_241960.1 OG7 LdBPK_110640.1 ↔ LdBPK_241960.1 OG7 LdBPK_241960.1 ↔ LdBPK_332700.1	OG7
LAMA_000223300 ⚠ Serine hydroxymethyltransferase, putative	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_010621	OG7
LAMA_000237000 ⚠ Endonuclease/Exonuclease/phosphatase family/R	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007569	OG7
LAMA_000214300 ⚠ N-terminal conserved domain of Nudc./CS domai	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_010327	OG7
LAMA_000032800 ⚠ ThiF family, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010542	OG7
LAMA_000473300 ⚠ WD domain, G-beta repeat/PFU (PLAA family ubi	—	OG6 TCSYLVIO_001314 ↔ TCSYLVIO_001670 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_001670	Both
LAMA_000768100 ⚠ Pyruvate kinase, barrel domain/Pyruvate kinas	—	OG6 Tb927.10.14140 ↔ Tb927.11.6590 OG7 Tb927.10.14140 ↔ Tb927.11.6590	Both
LAMA_000222100 ⚠ YjeF-related protein N-terminus/Carbohydrate	—	OG6 Tb927.11.6590 ↔ Tb927.7.3770 OG7 Tb927.11.6590 ↔ Tb927.7.3770	Both
LAMA_000808100 ⚠ Elongation factor Tu GTP binding domain/Elong	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
LAMA_000749800 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
LAMA_000264200 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
LAMA_000264000 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
LAMA_000509300 ⚠ Regulator of chromosome condensation (RCC1) r	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
LAMA_000592800 ⚠ CS domain containing protein, putative	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_010327	OG7
LAMA_000304200 ⚠ FKBP-type peptidyl-prolyl cis-trans isomerase	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
LAMA_000600500 ⚠ tRNA pseudouridine synthase, putative	—	OG6 Tb927.11.6590 ↔ Tb927.6.2970 OG7 Tb927.11.6590 ↔ Tb927.6.2970	Both
LAMA_000107800 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_130530.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_130530.1 OG7 LdBPK_110640.1 ↔ LdBPK_130530.1	OG7
LAMA_000042000 ⚠ ABC transporter, putative	—	OG7 LdBPK_330340.1 ↔ LdBPK_332700.1	OG7
LAMA_000323700 ⚠ PH domain associated with Beige/BEACH/Beige/B	—	OG7 LdBPK_110630.1 ↔ LdBPK_332920.1	OG7
LAMA_000515800 ⚠ MORN repeat/FYVE zinc finger containing prote	—	OG7 LdBPK_110640.1 ↔ LdBPK_180610.1	OG7
LAMA_000437500 ⚠ tRNA synthetases class I (W and Y), putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_290060.1 OG7 LdBPK_110640.1 ↔ LdBPK_290060.1 OG7 LdBPK_290060.1 ↔ LdBPK_332700.1	OG7
LAMA_000052500 ⚠ RNA pseudouridylate synthase, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_261140.1 OG7 LdBPK_110640.1 ↔ LdBPK_261140.1 OG7 LdBPK_261140.1 ↔ LdBPK_332700.1	OG7
LAMA_000174600 ⚠ Regulator of chromosome condensation (RCC1) r	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
LAMA_000626200 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_110640.1 ↔ LdBPK_310320.1	OG7
LAMA_000298700 ⚠ FKBP-type peptidyl-prolyl cis-trans isomerase	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
LAMA_000784100 ⚠ Ubiquitin carboxyl-terminal hydrolase/ICP0-bi	—	OG7 LdBPK_332700.1 ↔ LdBPK_343890.1	OG7
LAMA_000741600 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007569	OG7
LAMA_000307900 ⚠ FKBP-type peptidyl-prolyl cis-trans isomerase	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
LAMA_000431800 ⚠ FKBP-type peptidyl-prolyl cis-trans isomerase	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7

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