LAMA_000013500

M17 aminopeptidase N-terminal domain 2, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_142599 OG7: OG7_0003405 266 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 266 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000633600 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— +9 more Both
LAMA_000600000 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— +9 more Both
LAMA_000054400 ⚠
Domain of unknown function (DUF1935)/Calpain
— OG6
LAMA_000347500 ⚠
hypothetical protein, conserved
— +2 more Both
LAMA_000557900 ⚠
Rrp44-like cold shock domain/Dis3-like cold-s
— +2 more Both
LAMA_000362600 ⚠
tRNA synthetases class I (I, L, M and V)/Anti
— Both
LAMA_000053300 ⚠
RNB domain containing protein, putative
— OG7
LAMA_000559100 ⚠
RNB domain containing protein, putative
— OG7
LAMA_000132900 ⚠
WD domain, G-beta repeat, putative
— Both
LAMA_000096200 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— +2 more Both
LAMA_000778900 ⚠
FAD dependent oxidoreductase/Pyridine nucleot
— +2 more Both
LAMA_000775500 ⚠
ApbE family/Alanine dehydrogenase/PNT, C-term
— +2 more Both
LAMA_000590700 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— OG7
LAMA_000389400 ⚠
Domain of unknown function (DUF1935)/Calpain
— OG6
LAMA_000778800 ⚠
ApbE family/Alanine dehydrogenase/PNT, C-term
— +2 more Both
LAMA_000593700 ⚠
hypothetical protein, conserved
— Both
LAMA_000406400 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— OG7
LAMA_000389300 ⚠
hypothetical protein
— OG6
LAMA_000591800 ⚠
hypothetical protein, conserved
— Both
LAMA_000031500 ⚠
Aspartyl protease/gag-polyprotein putative as
— +3 more Both
LAMA_000747000 ⚠
Glutaminyl-tRNA synthetase, non-specific RNA
— +1 more Both
LAMA_000473100 ⚠
Cyclin/Cyclin, N-terminal domain containing p
— OG7
LAMA_000223300 ⚠
Serine hydroxymethyltransferase, putative
— OG7
LAMA_000237000 ⚠
Endonuclease/Exonuclease/phosphatase family/R
— OG7
LAMA_000214300 ⚠
N-terminal conserved domain of Nudc./CS domai
— OG7
LAMA_000032800 ⚠
ThiF family, putative
— OG7
LAMA_000473300 ⚠
WD domain, G-beta repeat/PFU (PLAA family ubi
— Both
LAMA_000768100 ⚠
Pyruvate kinase, barrel domain/Pyruvate kinas
— Both
LAMA_000222100 ⚠
YjeF-related protein N-terminus/Carbohydrate
— Both
LAMA_000808100 ⚠
Elongation factor Tu GTP binding domain/Elong
— OG7
LAMA_000749800 ⚠
Acyl CoA binding protein, putative
— OG7
LAMA_000264200 ⚠
Acyl CoA binding protein, putative
— OG7
LAMA_000264000 ⚠
Acyl CoA binding protein, putative
— OG7
LAMA_000509300 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000592800 ⚠
CS domain containing protein, putative
— OG7
LAMA_000304200 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LAMA_000600500 ⚠
tRNA pseudouridine synthase, putative
— Both
LAMA_000107800 ⚠
hypothetical protein, conserved
— OG7
LAMA_000042000 ⚠
ABC transporter, putative
— OG7
LAMA_000323700 ⚠
PH domain associated with Beige/BEACH/Beige/B
— OG7
LAMA_000515800 ⚠
MORN repeat/FYVE zinc finger containing prote
— OG7
LAMA_000437500 ⚠
tRNA synthetases class I (W and Y), putative
— OG7
LAMA_000052500 ⚠
RNA pseudouridylate synthase, putative
— OG7
LAMA_000174600 ⚠
Regulator of chromosome condensation (RCC1) r
— OG7
LAMA_000626200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000298700 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LAMA_000784100 ⚠
Ubiquitin carboxyl-terminal hydrolase/ICP0-bi
— OG7
LAMA_000741600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000307900 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LAMA_000431800 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.