LAMA_000775500

ApbE family/Alanine dehydrogenase/PNT, C-terminal domain/Pyridine nucleotide-disulphide oxidoreductase/FAD dependent oxidoreductase/Glucose inhibited division protein A/FAD binding domain/NAD(P)-binding Rossmann-like domain/Oxidoreductase FAD-binding domain/Oxidoreductase NAD-binding domain containing protein, putative

Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_104311 OG7: OG7_0003099 156 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 156 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAMA_000013500 ⚠ M17 aminopeptidase N-terminal domain 2, putat	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
LAMA_000579400 ⚠ ATP synthase alpha/beta family, beta-barrel d	—	OG6 TCSYLVIO_002668 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_002668 ↔ TCSYLVIO_008502 OG6 Tb927.10.3650 ↔ Tb927.11.11690 OG7 Tb927.10.3650 ↔ Tb927.11.11690 +2 more	Both
LAMA_000593700 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_300810.1 ↔ LdBPK_350850.1 OG6 TCSYLVIO_003145 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_003145 ↔ TCSYLVIO_008502 OG7 LdBPK_300810.1 ↔ LdBPK_350850.1 +2 more	Both
LAMA_000721900 ⚠ M17 aminopeptidase N-terminal domain 2/Cytoso	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
LAMA_000514000 ⚠ Hsp70 protein/MreB/Mbl protein, putative	—	OG6 TCSYLVIO_002696 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_002696 ↔ TCSYLVIO_008502	OG6
LAMA_000180100 ⚠ Adaptin N terminal region/non-SMC mitotic con	—	OG7 TCSYLVIO_004597 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_008502	OG7
LAMA_000021200 ⚠ Hsp70 protein, putative	—	OG6 TCSYLVIO_002696 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_002696 ↔ TCSYLVIO_008502	OG6
LAMA_000583300 ⚠ Hsp70 protein/MreB/Mbl protein, putative	—	OG6 TCSYLVIO_002696 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_002696 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_002696 ↔ TCSYLVIO_005116 OG7 TCSYLVIO_002696 ↔ TCSYLVIO_008502	Both
LAMA_000423100 ⚠ tRNA-methyltransferase O, putative	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_001255 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_005116 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_008502	Both
LAMA_000125200 ⚠ hypothetical protein, conserved	—	OG6 Tb927.3.5310 ↔ Tb927.5.940 OG7 Tb927.3.5310 ↔ Tb927.5.940	Both
LAMA_000279700 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_180660.1 ↔ LdBPK_350850.1 OG7 LdBPK_180660.1 ↔ LdBPK_350850.1	Both
LAMA_000768100 ⚠ Pyruvate kinase, barrel domain/Pyruvate kinas	—	OG6 Tb927.10.14140 ↔ Tb927.5.930 OG7 Tb927.10.14140 ↔ Tb927.5.930	Both
LAMA_000031500 ⚠ Aspartyl protease/gag-polyprotein putative as	—	OG6 TCSYLVIO_003428 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_003428 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_003428 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_003428 ↔ TCSYLVIO_005116 +2 more	Both
LAMA_000473300 ⚠ WD domain, G-beta repeat/PFU (PLAA family ubi	—	OG6 TCSYLVIO_001314 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001314 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_008502	Both
LAMA_000425900 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_220710.1 ↔ LdBPK_350850.1 OG7 LdBPK_220710.1 ↔ LdBPK_350850.1	Both
LAMA_000598500 ⚠ Zinc finger, C3HC4 type (RING finger) contain	—	OG6 TCSYLVIO_003179 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_003179 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_003179 ↔ TCSYLVIO_005116 OG7 TCSYLVIO_003179 ↔ TCSYLVIO_008502	Both
LAMA_000325900 ⚠ Ribosomal L37ae protein family, putative	—	OG6 LdBPK_212190.1 ↔ LdBPK_350850.1 OG7 LdBPK_212190.1 ↔ LdBPK_350850.1	Both
LAMA_000078900 ⚠ Glutamine synthetase, beta-Grasp domain/Gluta	—	OG6 Tb927.5.930 ↔ Tb927.7.4970 OG6 Tb927.10.3650 ↔ Tb927.7.4970 OG7 Tb927.5.930 ↔ Tb927.7.4970 OG7 Tb927.10.3650 ↔ Tb927.7.4970	Both
LAMA_000209700 ⚠ NADP oxidoreductase coenzyme F420-dependent/N	—	OG6 Tb927.5.930 ↔ Tb927.7.2440 OG7 Tb927.5.930 ↔ Tb927.7.2440	Both
LAMA_000440900 ⚠ CAF1 family ribonuclease, putative	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_008502	Both
LAMA_000370600 ⚠ CAF1 family ribonuclease, putative	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_008502	Both
LAMA_000441000 ⚠ CAF1 family ribonuclease, putative	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_008502	Both
LAMA_000122600 ⚠ NF-X1 type zinc finger containing protein, pu	—	OG6 LdBPK_290620.1 ↔ LdBPK_350850.1 OG7 LdBPK_290620.1 ↔ LdBPK_350850.1	Both
LAMA_000423700 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001262 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_001262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001262 ↔ TCSYLVIO_005116 OG7 TCSYLVIO_001262 ↔ TCSYLVIO_008502	Both
LAMA_000520200 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003586 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_003586 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_008502	Both
LAMA_000168600 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003586 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_003586 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_008502	Both
LAMA_000291700 ⚠ CrtC N-terminal lipocalin domain/Lipocalin-li	—	OG6 LdBPK_190210.1 ↔ LdBPK_350850.1 OG7 LdBPK_190210.1 ↔ LdBPK_350850.1	Both
LAMA_000406400 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_003107 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005116 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_005159 +2 more	Both
LAMA_000590700 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_003107 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005116 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_005159 +2 more	Both
LAMA_000172400 ⚠ Inorganic pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008502	Both
LAMA_000049500 ⚠ Inorganic pyrophosphatase, putative	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_008502	Both
LAMA_000774200 ⚠ ATP synthase subunit D, putative	—	OG6 TCSYLVIO_005104 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_005104 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_005104 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_005104 ↔ TCSYLVIO_008502	Both
LAMA_000349600 ⚠ Leucine Rich repeat, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008502	OG6
LAMA_000202000 ⚠ N2,N2-dimethylguanosine tRNA methyltransferas	—	OG6 TCSYLVIO_002844 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_002844 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_002844 ↔ TCSYLVIO_005116 OG7 TCSYLVIO_002844 ↔ TCSYLVIO_008502	Both
LAMA_000591800 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_003118 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_008502	Both
LAMA_000474600 ⚠ Tubulin folding cofactor D C terminal, putati	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005116 +2 more	Both
LAMA_000186600 ⚠ Pyridoxal-dependent decarboxylase, pyridoxal	—	OG6 LdBPK_120105.1 ↔ LdBPK_350850.1 OG7 LdBPK_120105.1 ↔ LdBPK_350850.1	Both
LAMA_000070600 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_005116 ↔ TCSYLVIO_006138	OG7
LAMA_000310700 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_005116 ↔ TCSYLVIO_006138	OG7
LAMA_000125800 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_005116 ↔ TCSYLVIO_006138	OG7
LAMA_000676000 ⚠ Importin repeat, putative	—	OG7 LdBPK_070810.1 ↔ LdBPK_350850.1	OG7
LAMA_000714300 ⚠ Protein kinase domain/Protein tyrosine kinase	—	OG7 TCSYLVIO_008502 ↔ TCSYLVIO_009362 OG7 TCSYLVIO_005116 ↔ TCSYLVIO_009362	OG7
LAMA_000227200 ⚠ Protein kinase domain/Protein tyrosine kinase	—	OG7 TCSYLVIO_008502 ↔ TCSYLVIO_009362 OG7 TCSYLVIO_005116 ↔ TCSYLVIO_009362	OG7
LAMA_000220700 ⚠ Protein tyrosine kinase/Protein kinase domain	—	OG7 TCSYLVIO_008502 ↔ TCSYLVIO_009362 OG7 TCSYLVIO_005116 ↔ TCSYLVIO_009362	OG7
LAMA_000236600 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_005118 ↔ TCSYLVIO_007058	OG7
LAMA_000686900 ⚠ IQ calmodulin-binding motif containing protei	—	OG7 TCSYLVIO_005118 ↔ TCSYLVIO_005299	OG7
LAMA_000785300 ⚠ Protein kinase domain/Protein tyrosine kinase	—	OG7 TCSYLVIO_008502 ↔ TCSYLVIO_009362 OG7 TCSYLVIO_005116 ↔ TCSYLVIO_009362	OG7
LAMA_000542900 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_005512 OG7 TCSYLVIO_005512 ↔ TCSYLVIO_008502	OG7
LAMA_000720600 ⚠ Histidine kinase-, DNA gyrase B-, and HSP90-l	—	OG7 TCSYLVIO_008502 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_009400 +2 more	OG7
LAMA_000032800 ⚠ ThiF family, putative	—	OG7 TCSYLVIO_008502 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_010542	OG7

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