LAMA_000423700

hypothetical protein, conserved
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_139815 OG7: OG7_0037740 139 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 139 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000278400
hypothetical protein, conserved
— Both
LAMA_000715300
Histone-binding protein RBBP4 or subunit C of
— Both
LAMA_000285900
hypothetical protein, conserved
— Both
LAMA_000285400
Aminoacyl-tRNA editing domain/tRNA synthetase
— Both
LAMA_000389400 ⚠
Domain of unknown function (DUF1935)/Calpain
— OG6
LAMA_000083500 ⚠
TLD, putative
— OG7
LAMA_000732400 ⚠
tRNA pseudouridine synthase, putative
— Both
LAMA_000589400
Microtubule binding/Kinesin motor domain cont
— OG6
LAMA_000617700
hypothetical protein, conserved
— Both
LAMA_000349600
Leucine Rich repeat, putative
— OG6
LAMA_000598500
Zinc finger, C3HC4 type (RING finger) contain
— Both
LAMA_000776200
hypothetical protein, conserved
— Both
LAMA_000202000
N2,N2-dimethylguanosine tRNA methyltransferas
— Both
LAMA_000514000 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— OG6
LAMA_000021200 ⚠
Hsp70 protein, putative
— OG6
LAMA_000125500
STI1 domain containing protein, putative
— Both
LAMA_000095700 ⚠
6-phosphofructo-2-kinase, putative
— Both
LAMA_000775500 ⚠
ApbE family/Alanine dehydrogenase/PNT, C-term
— Both
LAMA_000778900 ⚠
FAD dependent oxidoreductase/Pyridine nucleot
— Both
LAMA_000583300 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— Both
LAMA_000054400 ⚠
Domain of unknown function (DUF1935)/Calpain
— OG6
LAMA_000096200 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— Both
LAMA_000415500 ⚠
Protein kinase domain/Protein tyrosine kinase
— Both
LAMA_000411500
V-ATPase subunit H, putative
— Both
LAMA_000337300
ATP synthase (E/31 kDa) subunit, putative
— Both
LAMA_000394000
hypothetical protein, conserved
— Both
LAMA_000728500 ⚠
Zn-finger in Ran binding protein and others,
— Both
LAMA_000510300 ⚠
Endonuclease/Exonuclease/phosphatase family,
— OG7
LAMA_000386800 ⚠
Probable Zinc-ribbon domain containing protei
— OG7
LAMA_000106600 ⚠
Probable Zinc-ribbon domain containing protei
— OG7
LAMA_000032800 ⚠
ThiF family, putative
— OG7
LAMA_000811100 ⚠
LSM domain containing protein, putative
— OG7
LAMA_000597100 ⚠
WW domain containing protein, putative
— OG7
LAMA_000495300 ⚠
LSM domain containing protein, putative
— OG7
LAMA_000253000 ⚠
WW domain containing protein, putative
— OG7
LAMA_000090400 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LAMA_000820400 ⚠
SPRY domain/HECT-domain (ubiquitin-transferas
— OG7
LAMA_000374800 ⚠
DNA polymerase III, delta subunit/ATPase fami
— OG7
LAMA_000158000
hypothetical protein, conserved
— OG7
LAMA_000747000 ⚠
Glutaminyl-tRNA synthetase, non-specific RNA
— OG7
LAMA_000306400 ⚠
Leucine carboxyl methyltransferase, putative
— OG7
LAMA_000785300 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000070600 ⚠
zinc-finger of a C2HC-type, putative
— OG7
LAMA_000506600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000714300 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000636000
SPRY domain containing protein, putative
— OG7
LAMA_000310700 ⚠
zinc-finger of a C2HC-type, putative
— OG7
LAMA_000326300 ⚠
TLD, putative
— OG7
LAMA_000168500 ⚠
Zn-finger in Ran binding protein and others,
— OG7
LAMA_000320500 ⚠
Zn-finger in Ran binding protein and others,
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.