LAMA_000285400

Aminoacyl-tRNA editing domain/tRNA synthetase class II core domain (G, H, P, S and T)/Anticodon binding domain/Prolyl-tRNA synthetase, C-terminal, putative

Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100749 OG7: OG7_0002333 182 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 182 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAMA_000278400 hypothetical protein, conserved	—	OG6 LdBPK_180550.1 ↔ LdBPK_181230.1 OG6 TCSYLVIO_006181 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_006181 ↔ TCSYLVIO_006246 OG7 LdBPK_180550.1 ↔ LdBPK_181230.1	Both
LAMA_000186300 tRNA synthetases class I (C) catalytic domain	—	OG6 LdBPK_120255.1 ↔ LdBPK_181220.1 OG6 LdBPK_120255.1 ↔ LdBPK_181230.1 OG6 Tb927.10.12890 ↔ Tb927.6.950 OG7 Tb927.10.12890 ↔ Tb927.6.950 +2 more	Both
LAMA_000423700 hypothetical protein, conserved	—	OG6 LdBPK_181230.1 ↔ LdBPK_220520.1 OG6 TCSYLVIO_001262 ↔ TCSYLVIO_006246 OG7 LdBPK_181230.1 ↔ LdBPK_220520.1 OG7 TCSYLVIO_001262 ↔ TCSYLVIO_006246	Both
LAMA_000474600 Tubulin folding cofactor D C terminal, putati	—	OG6 LdBPK_181220.1 ↔ LdBPK_242100.1 OG6 LdBPK_181230.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_242100.1 +2 more	Both
LAMA_000406400 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
LAMA_000590700 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
LAMA_000747000 ⚠ Glutaminyl-tRNA synthetase, non-specific RNA	—	OG6 LdBPK_181220.1 ↔ LdBPK_342110.1 OG6 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 +1 more	Both
LAMA_000285900 hypothetical protein, conserved	—	OG6 TCSYLVIO_006238 ↔ TCSYLVIO_006246 OG6 LdBPK_181230.1 ↔ LdBPK_181300.1 OG7 LdBPK_181230.1 ↔ LdBPK_181300.1 OG7 TCSYLVIO_006238 ↔ TCSYLVIO_006246	Both
LAMA_000715300 Histone-binding protein RBBP4 or subunit C of	—	OG6 TCSYLVIO_005619 ↔ TCSYLVIO_006246 OG6 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 TCSYLVIO_005619 ↔ TCSYLVIO_006246	Both
LAMA_000719300 PPPDE putative peptidase domain/PUB domain/Gl	—	OG6 LdBPK_181230.1 ↔ LdBPK_332390.1 OG7 LdBPK_181230.1 ↔ LdBPK_332390.1	Both
LAMA_000636000 SPRY domain containing protein, putative	—	OG7 TCSYLVIO_002919 ↔ TCSYLVIO_006246	OG7
LAMA_000643700 hypothetical protein, conserved	—	OG6 LdBPK_181220.1 ↔ LdBPK_312230.1 OG6 LdBPK_181230.1 ↔ LdBPK_312230.1 OG7 LdBPK_181220.1 ↔ LdBPK_312230.1 OG7 LdBPK_181230.1 ↔ LdBPK_312230.1	Both
LAMA_000437700 hypothetical protein, conserved	—	OG6 LdBPK_181220.1 ↔ LdBPK_230360.1 OG6 LdBPK_181230.1 ↔ LdBPK_230360.1 OG7 LdBPK_181220.1 ↔ LdBPK_230360.1 OG7 LdBPK_181230.1 ↔ LdBPK_230360.1	Both
LAMA_000513400 hypothetical protein, conserved	—	OG6 LdBPK_181230.1 ↔ LdBPK_261160.1 OG7 LdBPK_181230.1 ↔ LdBPK_261160.1	Both
LAMA_000266300 ⚠ IMP dehydrogenase / GMP reductase domain/CBS	—	OG6 LdBPK_181220.1 ↔ LdBPK_191590.1 OG6 LdBPK_181230.1 ↔ LdBPK_191590.1	OG6
LAMA_000104800 Aminopeptidase I zinc metalloprotease (M18)/M	—	OG6 LdBPK_181220.1 ↔ LdBPK_292470.1 OG6 LdBPK_181230.1 ↔ LdBPK_292470.1 OG7 LdBPK_181220.1 ↔ LdBPK_292470.1 OG7 LdBPK_181230.1 ↔ LdBPK_292470.1	Both
LAMA_000304500 ⚠ IMP dehydrogenase / GMP reductase domain/CBS	—	OG6 LdBPK_181220.1 ↔ LdBPK_191590.1 OG6 LdBPK_181230.1 ↔ LdBPK_191590.1 OG7 LdBPK_181220.1 ↔ LdBPK_191590.1 OG7 LdBPK_181230.1 ↔ LdBPK_191590.1	Both
LAMA_000602700 CLASP N terminal, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_301760.1 OG6 LdBPK_181230.1 ↔ LdBPK_301760.1 OG7 LdBPK_181220.1 ↔ LdBPK_301760.1 OG7 LdBPK_181230.1 ↔ LdBPK_301760.1	Both
LAMA_000299500 hypothetical protein, conserved	—	OG6 LdBPK_181230.1 ↔ LdBPK_191020.1 OG7 LdBPK_181230.1 ↔ LdBPK_191020.1	Both
LAMA_000405800 Domain of unknown function (DUF4042), putativ	—	OG6 LdBPK_181220.1 ↔ LdBPK_211060.1 OG6 LdBPK_181230.1 ↔ LdBPK_211060.1 OG7 LdBPK_181220.1 ↔ LdBPK_211060.1 OG7 LdBPK_181230.1 ↔ LdBPK_211060.1	Both
LAMA_000423100 tRNA-methyltransferase O, putative	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_006246	Both
LAMA_000179200 PUB domain containing protein, putative	—	OG6 LdBPK_110920.1 ↔ LdBPK_181220.1 OG6 LdBPK_110920.1 ↔ LdBPK_181230.1 OG7 LdBPK_110920.1 ↔ LdBPK_181220.1 OG7 LdBPK_110920.1 ↔ LdBPK_181230.1	Both
LAMA_000097900 Domain of unknown function (DUF3437), putativ	—	OG6 LdBPK_071090.1 ↔ LdBPK_181220.1 OG6 LdBPK_071090.1 ↔ LdBPK_181230.1 OG7 LdBPK_071090.1 ↔ LdBPK_181220.1 OG7 LdBPK_071090.1 ↔ LdBPK_181230.1	Both
LAMA_000189000 ⚠ WW domain containing protein, putative	—	OG6 LdBPK_120470.1 ↔ LdBPK_181220.1 OG6 LdBPK_120470.1 ↔ LdBPK_181230.1 OG7 LdBPK_120470.1 ↔ LdBPK_181220.1 OG7 LdBPK_120470.1 ↔ LdBPK_181230.1	Both
LAMA_000132900 WD domain, G-beta repeat, putative	—	OG6 LdBPK_080420.1 ↔ LdBPK_181220.1 OG6 LdBPK_080420.1 ↔ LdBPK_181230.1 OG7 LdBPK_080420.1 ↔ LdBPK_181220.1 OG7 LdBPK_080420.1 ↔ LdBPK_181230.1	Both
LAMA_000031500 Aspartyl protease/gag-polyprotein putative as	—	OG6 TCSYLVIO_003428 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_003428 ↔ TCSYLVIO_006246	Both
LAMA_000598500 Zinc finger, C3HC4 type (RING finger) contain	—	OG6 TCSYLVIO_003179 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_003179 ↔ TCSYLVIO_006246	Both
LAMA_000178900 Leucine Rich repeat, putative	—	OG6 LdBPK_110890.1 ↔ LdBPK_181220.1 OG6 LdBPK_110890.1 ↔ LdBPK_181230.1 OG7 LdBPK_110890.1 ↔ LdBPK_181220.1 OG7 LdBPK_110890.1 ↔ LdBPK_181230.1	Both
LAMA_000012800 Soluble NSF attachment protein, SNAP, putativ	—	OG6 LdBPK_020280.1 ↔ LdBPK_181220.1 OG6 LdBPK_020280.1 ↔ LdBPK_181230.1 OG7 LdBPK_020280.1 ↔ LdBPK_181220.1 OG7 LdBPK_020280.1 ↔ LdBPK_181230.1	Both
LAMA_000283700 Hydantoinase/oxoprolinase N-terminal region/H	—	OG6 LdBPK_181050.1 ↔ LdBPK_181220.1 OG6 LdBPK_181050.1 ↔ LdBPK_181230.1 OG7 LdBPK_181050.1 ↔ LdBPK_181220.1 OG7 LdBPK_181050.1 ↔ LdBPK_181230.1	Both
LAMA_000349600 Leucine Rich repeat, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006246	OG6
LAMA_000202000 N2,N2-dimethylguanosine tRNA methyltransferas	—	OG6 TCSYLVIO_002844 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_002844 ↔ TCSYLVIO_006246	Both
LAMA_000274400 ⚠ zinc-finger of a C2HC-type/Double zinc ribbon	—	OG6 TCSYLVIO_006138 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	Both
LAMA_000070600 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
LAMA_000310700 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
LAMA_000125800 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
LAMA_000721900 ⚠ M17 aminopeptidase N-terminal domain 2/Cytoso	—	OG7 LdBPK_110640.1 ↔ LdBPK_181220.1 OG7 LdBPK_110640.1 ↔ LdBPK_181230.1	OG7
LAMA_000597100 ⚠ WW domain containing protein, putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1 OG7 LdBPK_181230.1 ↔ LdBPK_300970.1	OG7
LAMA_000090400 ⚠ HECT-domain (ubiquitin-transferase), putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1 OG7 LdBPK_181230.1 ↔ LdBPK_300970.1	OG7
LAMA_000820400 ⚠ SPRY domain/HECT-domain (ubiquitin-transferas	—	OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1 OG7 LdBPK_181230.1 ↔ LdBPK_300970.1	OG7
LAMA_000505500 ⚠ Ankyrin repeats (3 copies)/Ankyrin repeats (m	—	OG7 TCSYLVIO_004468 ↔ TCSYLVIO_006246	OG7
LAMA_000307100 ⚠ Histidine phosphatase superfamily (branch 1),	—	OG7 TCSYLVIO_004468 ↔ TCSYLVIO_006246	OG7
LAMA_000811100 ⚠ LSM domain containing protein, putative	—	OG7 LdBPK_181230.1 ↔ LdBPK_260010.1	OG7
LAMA_000661500 ⚠ Leucine rich repeat, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_261200.1 OG7 LdBPK_181230.1 ↔ LdBPK_261200.1	OG7
LAMA_000626200 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_181220.1 ↔ LdBPK_310320.1 OG7 LdBPK_181230.1 ↔ LdBPK_310320.1	OG7
LAMA_000544700 ⚠ Eukaryotic initiation factor 4E, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_300460.1 OG7 LdBPK_181230.1 ↔ LdBPK_300460.1	OG7
LAMA_000495300 ⚠ LSM domain containing protein, putative	—	OG7 LdBPK_181230.1 ↔ LdBPK_260010.1	OG7
LAMA_000122600 ⚠ NF-X1 type zinc finger containing protein, pu	—	OG7 LdBPK_181220.1 ↔ LdBPK_220007.1 OG7 LdBPK_181230.1 ↔ LdBPK_220007.1	OG7
LAMA_000374800 ⚠ DNA polymerase III, delta subunit/ATPase fami	—	OG7 LdBPK_181220.1 ↔ LdBPK_241010.1 OG7 LdBPK_181230.1 ↔ LdBPK_241010.1	OG7
LAMA_000514200 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_180610.1 ↔ LdBPK_181220.1 OG7 LdBPK_180610.1 ↔ LdBPK_181230.1	OG7

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