LAMA_000202000

N2,N2-dimethylguanosine tRNA methyltransferase, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_101071 OG7: OG7_0004550 60 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 60 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000600500 ⚠
tRNA pseudouridine synthase, putative
— OG7
LAMA_000598500
Zinc finger, C3HC4 type (RING finger) contain
— Both
LAMA_000776200
hypothetical protein, conserved
— Both
LAMA_000125500
STI1 domain containing protein, putative
— Both
LAMA_000095700 ⚠
6-phosphofructo-2-kinase, putative
— Both
LAMA_000775500 ⚠
ApbE family/Alanine dehydrogenase/PNT, C-term
— Both
LAMA_000778900 ⚠
FAD dependent oxidoreductase/Pyridine nucleot
— Both
LAMA_000054400 ⚠
Domain of unknown function (DUF1935)/Calpain
— OG6
LAMA_000096200 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— Both
LAMA_000415500 ⚠
Protein kinase domain/Protein tyrosine kinase
— Both
LAMA_000411500
V-ATPase subunit H, putative
— Both
LAMA_000337300
ATP synthase (E/31 kDa) subunit, putative
— Both
LAMA_000474600
Tubulin folding cofactor D C terminal, putati
— Both
LAMA_000505500 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000349800 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000278400
hypothetical protein, conserved
— Both
LAMA_000299200 ⚠
tRNA pseudouridine synthase, putative
— OG7
LAMA_000307100 ⚠
Histidine phosphatase superfamily (branch 1),
— OG7
LAMA_000747000 ⚠
Glutaminyl-tRNA synthetase, non-specific RNA
— OG7
LAMA_000306400 ⚠
Leucine carboxyl methyltransferase, putative
— OG7
LAMA_000785300 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000070600 ⚠
zinc-finger of a C2HC-type, putative
— OG7
LAMA_000506600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000714300 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000636000
SPRY domain containing protein, putative
— OG7
LAMA_000310700 ⚠
zinc-finger of a C2HC-type, putative
— OG7
LAMA_000158000
hypothetical protein, conserved
— OG7
LAMA_000220700 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000227200 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000125800 ⚠
zinc-finger of a C2HC-type, putative
— OG7
LAMA_000285400
Aminoacyl-tRNA editing domain/tRNA synthetase
— Both
LAMA_000618200 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeat/Ank
— OG6
LAMA_000579400
ATP synthase alpha/beta family, beta-barrel d
— Both
LAMA_000567600 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— OG6
LAMA_000514000 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— OG6
LAMA_000021200 ⚠
Hsp70 protein, putative
— OG6
LAMA_000583300 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— Both
LAMA_000423100
tRNA-methyltransferase O, putative
— Both
LAMA_000423700
hypothetical protein, conserved
— Both
LAMA_000389300 ⚠
hypothetical protein
— OG6
LAMA_000406400 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— Both
LAMA_000128600
Metallopeptidase family M24/FACT complex subu
— Both
LAMA_000031500
Aspartyl protease/gag-polyprotein putative as
— Both
LAMA_000590700 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— Both
LAMA_000760000
ATP synthase alpha/beta family, beta-barrel d
— Both
LAMA_000561600 ⚠
Ankyrin repeats (many copies)/Ankyrin repeats
— OG6
LAMA_000412200
Dehydrogenase E1 component, putative
— Both
LAMA_000500300
PCI domain containing protein, putative
— Both
LAMA_000274400 ⚠
zinc-finger of a C2HC-type/Double zinc ribbon
— Both
LAMA_000360600
Splicing factor 1 helix-hairpin domain/KH dom
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.