LAMA_000715300

Histone-binding protein RBBP4 or subunit C of CAF1 complex, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_102504 OG7: OG7_0007856 222 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 222 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000278400
hypothetical protein, conserved
— Both
LAMA_000285400
Aminoacyl-tRNA editing domain/tRNA synthetase
— Both
LAMA_000132900
WD domain, G-beta repeat, putative
— Both
LAMA_000032800 ⚠
ThiF family, putative
— OG7
LAMA_000600500 ⚠
tRNA pseudouridine synthase, putative
— Both
LAMA_000732400 ⚠
tRNA pseudouridine synthase, putative
— Both
LAMA_000285900
hypothetical protein, conserved
— Both
LAMA_000299200 ⚠
tRNA pseudouridine synthase, putative
— OG7
LAMA_000506600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000591800
hypothetical protein, conserved
— Both
LAMA_000131000 ⚠
ThiF family/Ubiquitin/SUMO-activating enzyme
— Both
LAMA_000423700
hypothetical protein, conserved
— Both
LAMA_000075500 ⚠
Pumilio-family RNA binding repeat, putative
— OG7
LAMA_000317300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000582600
Uncharacterized ACR, COG1678, putative
— OG7
LAMA_000593200 ⚠
GrpE, putative
— OG7
LAMA_000263200 ⚠
ATPase family associated with various cellula
— OG7
LAMA_000388300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000534400 ⚠
Rad17 P-loop domain/DNA polymerase III, delta
— OG7
LAMA_000598500
Zinc finger, C3HC4 type (RING finger) contain
— Both
LAMA_000799300 ⚠
Rad17 P-loop domain/DNA polymerase III, delta
— OG7
LAMA_000612400 ⚠
ATPase family associated with various cellula
— OG7
LAMA_000374800 ⚠
DNA polymerase III, delta subunit/ATPase fami
— OG7
LAMA_000307100 ⚠
Histidine phosphatase superfamily (branch 1),
— OG7
LAMA_000820400 ⚠
SPRY domain/HECT-domain (ubiquitin-transferas
— OG7
LAMA_000090400 ⚠
HECT-domain (ubiquitin-transferase), putative
— OG7
LAMA_000253000 ⚠
WW domain containing protein, putative
— OG7
LAMA_000180100 ⚠
Adaptin N terminal region/non-SMC mitotic con
— OG7
LAMA_000597100 ⚠
WW domain containing protein, putative
— OG7
LAMA_000258900 ⚠
Anaphase-promoting complex subunit 11 RING-H2
— OG7
LAMA_000335500 ⚠
Ring finger domain/RING-like zinc finger/RING
— OG7
LAMA_000481600 ⚠
Ring finger domain containing protein, putati
— OG7
LAMA_000541100 ⚠
RING-H2 zinc finger domain/Ring finger domain
— OG7
LAMA_000143200 ⚠
Ring finger domain/RING-H2 zinc finger domain
— OG7
LAMA_000178900
Leucine Rich repeat, putative
— Both
LAMA_000411000 ⚠
Ring finger domain/RING-H2 zinc finger domain
— OG7
LAMA_000306000 ⚠
Pumilio-family RNA binding repeat, putative
— OG7
LAMA_000415800 ⚠
Pumilio-family RNA binding repeat, putative
— OG7
LAMA_000590700 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— Both
LAMA_000202000
N2,N2-dimethylguanosine tRNA methyltransferas
— Both
LAMA_000349600
Leucine Rich repeat, putative
— OG6
LAMA_000774200
ATP synthase subunit D, putative
— Both
LAMA_000049500 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000172400 ⚠
Inorganic pyrophosphatase, putative
— Both
LAMA_000460000 ⚠
Microtubule binding/Kinesin motor domain cont
— Both
LAMA_000520200 ⚠
hypothetical protein, conserved
— Both
LAMA_000441000 ⚠
CAF1 family ribonuclease, putative
— Both
LAMA_000549400
Ribonucleotide reductase, small chain, putati
— Both
LAMA_000474600
Tubulin folding cofactor D C terminal, putati
— Both
LAMA_000168600 ⚠
hypothetical protein, conserved
— Both
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.