LAMA_000633600

Peptidase family M20/M25/M40/Peptidase dimerisation domain containing protein, putative

Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_101553 OG7: OG7_0005942 169 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 169 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAMA_000013500 ⚠ M17 aminopeptidase N-terminal domain 2, putat	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
LAMA_000721900 ⚠ M17 aminopeptidase N-terminal domain 2/Cytoso	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
LAMA_000362600 ⚠ tRNA synthetases class I (I, L, M and V)/Anti	—	OG6 LdBPK_201720.1 ↔ LdBPK_365870.1 OG6 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_365870.1	Both
LAMA_000557900 ⚠ Rrp44-like cold shock domain/Dis3-like cold-s	—	OG6 LdBPK_201720.1 ↔ LdBPK_280470.1 OG6 LdBPK_201740.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 +1 more	Both
LAMA_000053300 ⚠ RNB domain containing protein, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	OG7
LAMA_000559100 ⚠ RNB domain containing protein, putative	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
LAMA_000515300 ⚠ Ferrous iron transport protein B/50S ribosome	—	OG7 LdBPK_050200.1 ↔ LdBPK_201720.1 OG7 LdBPK_050200.1 ↔ LdBPK_201740.1	OG7
LAMA_000590800 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_201720.1 ↔ LdBPK_300480.1 OG6 LdBPK_201740.1 ↔ LdBPK_300480.1 OG7 LdBPK_201720.1 ↔ LdBPK_300480.1 OG7 LdBPK_201740.1 ↔ LdBPK_300480.1	Both
LAMA_000786400 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_201720.1 ↔ LdBPK_351980.1 OG6 LdBPK_201740.1 ↔ LdBPK_351980.1 OG7 LdBPK_201720.1 ↔ LdBPK_351980.1 OG7 LdBPK_201740.1 ↔ LdBPK_351980.1	Both
LAMA_000513800 ⚠ Leucine Rich repeat, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_261200.1 OG6 LdBPK_201740.1 ↔ LdBPK_261200.1 OG7 LdBPK_201720.1 ↔ LdBPK_261200.1 OG7 LdBPK_201740.1 ↔ LdBPK_261200.1	Both
LAMA_000812000 ⚠ SET domain containing protein, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_354620.1 OG6 LdBPK_201740.1 ↔ LdBPK_354620.1 OG7 LdBPK_201720.1 ↔ LdBPK_354620.1 OG7 LdBPK_201740.1 ↔ LdBPK_354620.1	Both
LAMA_000779000 ⚠ DEAD/DEAH box helicase/AAA domain/Helicase co	—	OG6 LdBPK_201720.1 ↔ LdBPK_241120.1 OG6 LdBPK_201740.1 ↔ LdBPK_241120.1	OG6
LAMA_000507100 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_201720.1 ↔ LdBPK_260460.1 OG6 LdBPK_201740.1 ↔ LdBPK_260460.1 OG7 LdBPK_201720.1 ↔ LdBPK_260460.1 OG7 LdBPK_201740.1 ↔ LdBPK_260460.1	Both
LAMA_000488800 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_201720.1 ↔ LdBPK_251070.1 OG6 LdBPK_201740.1 ↔ LdBPK_251070.1 OG7 LdBPK_201720.1 ↔ LdBPK_251070.1 OG7 LdBPK_201740.1 ↔ LdBPK_251070.1	Both
LAMA_000486500 ⚠ DNL zinc finger containing protein, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_250830.1 OG6 LdBPK_201740.1 ↔ LdBPK_250830.1 OG7 LdBPK_201720.1 ↔ LdBPK_250830.1 OG7 LdBPK_201740.1 ↔ LdBPK_250830.1	Both
LAMA_000473200 ⚠ Cyclin/Cyclin, N-terminal domain containing p	—	OG6 LdBPK_201720.1 ↔ LdBPK_241960.1 OG6 LdBPK_201740.1 ↔ LdBPK_241960.1 OG7 LdBPK_201720.1 ↔ LdBPK_241960.1 OG7 LdBPK_201740.1 ↔ LdBPK_241960.1	Both
LAMA_000808100 ⚠ Elongation factor Tu GTP binding domain/Elong	—	OG6 LdBPK_201720.1 ↔ LdBPK_354220.1 OG6 LdBPK_201740.1 ↔ LdBPK_354220.1 OG7 LdBPK_201720.1 ↔ LdBPK_354220.1 OG7 LdBPK_201740.1 ↔ LdBPK_354220.1	Both
LAMA_000719300 ⚠ PPPDE putative peptidase domain/PUB domain/Gl	—	OG6 LdBPK_201720.1 ↔ LdBPK_332390.1 OG6 LdBPK_201740.1 ↔ LdBPK_332390.1 OG7 LdBPK_201720.1 ↔ LdBPK_332390.1 OG7 LdBPK_201740.1 ↔ LdBPK_332390.1	Both
LAMA_000513200 ⚠ RNA pseudouridylate synthase, putative	—	OG6 LdBPK_201720.1 ↔ LdBPK_261140.1 OG6 LdBPK_201740.1 ↔ LdBPK_261140.1 OG7 LdBPK_201720.1 ↔ LdBPK_261140.1 OG7 LdBPK_201740.1 ↔ LdBPK_261140.1	Both
LAMA_000115400 ⚠ Hsp70 protein/Tetratricopeptide repeat, putat	—	OG6 LdBPK_201720.1 ↔ LdBPK_291330.1 OG6 LdBPK_201740.1 ↔ LdBPK_291330.1 OG7 LdBPK_201720.1 ↔ LdBPK_291330.1 OG7 LdBPK_201740.1 ↔ LdBPK_291330.1	Both
LAMA_000464700 ⚠ Helicase conserved C-terminal domain/Helicase	—	OG6 LdBPK_201720.1 ↔ LdBPK_241120.1 OG6 LdBPK_201740.1 ↔ LdBPK_241120.1	OG6
LAMA_000106900 ⚠ Protein kinase domain/Protein tyrosine kinase	—	OG6 LdBPK_201720.1 ↔ LdBPK_292260.1 OG6 LdBPK_201740.1 ↔ LdBPK_292260.1 OG7 LdBPK_201720.1 ↔ LdBPK_292260.1 OG7 LdBPK_201740.1 ↔ LdBPK_292260.1	Both
LAMA_000730600 ⚠ lactate/malate dehydrogenase, NAD binding dom	—	OG6 TCSYLVIO_004390 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004390 ↔ TCSYLVIO_008414	Both
LAMA_000730800 ⚠ lactate/malate dehydrogenase, NAD binding dom	—	OG6 TCSYLVIO_004390 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004390 ↔ TCSYLVIO_008414	Both
LAMA_000291700 ⚠ CrtC N-terminal lipocalin domain/Lipocalin-li	—	OG6 LdBPK_190210.1 ↔ LdBPK_201720.1 OG6 LdBPK_190210.1 ↔ LdBPK_201740.1 OG7 LdBPK_190210.1 ↔ LdBPK_201720.1 OG7 LdBPK_190210.1 ↔ LdBPK_201740.1	Both
LAMA_000347500 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_008197 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_008197 ↔ TCSYLVIO_008414	Both
LAMA_000406400 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_008414	Both
LAMA_000590700 ⚠ OB-fold nucleic acid binding domain/tRNA synt	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_008414	Both
LAMA_000593200 ⚠ GrpE, putative	—	OG6 TCSYLVIO_003139 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_003139 ↔ TCSYLVIO_008414	Both
LAMA_000384900 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_200770.1 ↔ LdBPK_201720.1 OG6 LdBPK_200770.1 ↔ LdBPK_201740.1 OG7 LdBPK_200770.1 ↔ LdBPK_201720.1 OG7 LdBPK_200770.1 ↔ LdBPK_201740.1	Both
LAMA_000186600 ⚠ Pyridoxal-dependent decarboxylase, pyridoxal	—	OG6 LdBPK_120105.1 ↔ LdBPK_201720.1 OG6 LdBPK_120105.1 ↔ LdBPK_201740.1 OG7 LdBPK_120105.1 ↔ LdBPK_201720.1 OG7 LdBPK_120105.1 ↔ LdBPK_201740.1	Both
LAMA_000706800 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_004910 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_004910 ↔ TCSYLVIO_008414	Both
LAMA_000107800 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_130530.1 ↔ LdBPK_201720.1 OG7 LdBPK_130530.1 ↔ LdBPK_201740.1	OG7
LAMA_000749800 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_201720.1 OG7 LdBPK_090800.1 ↔ LdBPK_201740.1	OG7
LAMA_000264200 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_201720.1 OG7 LdBPK_090800.1 ↔ LdBPK_201740.1	OG7
LAMA_000264000 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_201720.1 OG7 LdBPK_090800.1 ↔ LdBPK_201740.1	OG7
LAMA_000757900 ⚠ TIP49 P-loop domain/Holliday junction DNA hel	—	OG7 TCSYLVIO_003846 ↔ TCSYLVIO_008414	OG7
LAMA_000530200 ⚠ SET domain containing protein, putative	—	OG7 LdBPK_080820.1 ↔ LdBPK_201720.1	OG7
LAMA_000444800 ⚠ SET domain containing protein, putative	—	OG7 LdBPK_080820.1 ↔ LdBPK_201720.1	OG7
LAMA_000471700 ⚠ SET domain containing protein, putative	—	OG7 LdBPK_080820.1 ↔ LdBPK_201720.1	OG7
LAMA_000739200 ⚠ SET domain containing protein, putative	—	OG7 LdBPK_080820.1 ↔ LdBPK_201720.1	OG7
LAMA_000700000 ⚠ SET domain containing protein, putative	—	OG7 LdBPK_080820.1 ↔ LdBPK_201720.1	OG7
LAMA_000193200 ⚠ SET domain containing protein, putative	—	OG7 LdBPK_080820.1 ↔ LdBPK_201720.1	OG7
LAMA_000444600 ⚠ SET domain containing protein, putative	—	OG7 LdBPK_080820.1 ↔ LdBPK_201720.1	OG7
LAMA_000084200 ⚠ SET domain/MYND finger containing protein, pu	—	OG7 LdBPK_080820.1 ↔ LdBPK_201720.1	OG7
LAMA_000157800 ⚠ DEAD/DEAH box helicase/Helicase conserved C-t	—	OG7 LdBPK_201720.1 ↔ LdBPK_282220.1 OG7 LdBPK_201740.1 ↔ LdBPK_282220.1	OG7
LAMA_000165200 ⚠ FKBP-type peptidyl-prolyl cis-trans isomerase	—	OG7 LdBPK_201720.1 ↔ LdBPK_291330.1 OG7 LdBPK_201740.1 ↔ LdBPK_291330.1	OG7
LAMA_000181600 ⚠ Elongation factor Tu GTP binding domain/Elong	—	OG7 LdBPK_201720.1 ↔ LdBPK_354220.1 OG7 LdBPK_201740.1 ↔ LdBPK_354220.1	OG7
LAMA_000487100 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_201720.1 ↔ LdBPK_331490.1 OG7 LdBPK_201740.1 ↔ LdBPK_331490.1	OG7
LAMA_000069200 ⚠ Cyclin, putative	—	OG7 LdBPK_201720.1 ↔ LdBPK_241960.1 OG7 LdBPK_201740.1 ↔ LdBPK_241960.1	OG7

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