LAMA_000633600

Peptidase family M20/M25/M40/Peptidase dimerisation domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_101553 OG7: OG7_0005942 169 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 169 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000013500 ⚠
M17 aminopeptidase N-terminal domain 2, putat
— +9 more Both
LAMA_000721900 ⚠
M17 aminopeptidase N-terminal domain 2/Cytoso
— +7 more Both
LAMA_000362600 ⚠
tRNA synthetases class I (I, L, M and V)/Anti
— Both
LAMA_000557900 ⚠
Rrp44-like cold shock domain/Dis3-like cold-s
— +1 more Both
LAMA_000053300 ⚠
RNB domain containing protein, putative
— OG7
LAMA_000559100 ⚠
RNB domain containing protein, putative
— Both
LAMA_000515300 ⚠
Ferrous iron transport protein B/50S ribosome
— OG7
LAMA_000590800 ⚠
hypothetical protein, conserved
— Both
LAMA_000786400 ⚠
hypothetical protein, conserved
— Both
LAMA_000513800 ⚠
Leucine Rich repeat, putative
— Both
LAMA_000812000 ⚠
SET domain containing protein, putative
— Both
LAMA_000779000 ⚠
DEAD/DEAH box helicase/AAA domain/Helicase co
— OG6
LAMA_000507100 ⚠
hypothetical protein, conserved
— Both
LAMA_000488800 ⚠
hypothetical protein, conserved
— Both
LAMA_000486500 ⚠
DNL zinc finger containing protein, putative
— Both
LAMA_000473200 ⚠
Cyclin/Cyclin, N-terminal domain containing p
— Both
LAMA_000808100 ⚠
Elongation factor Tu GTP binding domain/Elong
— Both
LAMA_000719300 ⚠
PPPDE putative peptidase domain/PUB domain/Gl
— Both
LAMA_000513200 ⚠
RNA pseudouridylate synthase, putative
— Both
LAMA_000115400 ⚠
Hsp70 protein/Tetratricopeptide repeat, putat
— Both
LAMA_000464700 ⚠
Helicase conserved C-terminal domain/Helicase
— OG6
LAMA_000106900 ⚠
Protein kinase domain/Protein tyrosine kinase
— Both
LAMA_000730600 ⚠
lactate/malate dehydrogenase, NAD binding dom
— Both
LAMA_000730800 ⚠
lactate/malate dehydrogenase, NAD binding dom
— Both
LAMA_000291700 ⚠
CrtC N-terminal lipocalin domain/Lipocalin-li
— Both
LAMA_000347500 ⚠
hypothetical protein, conserved
— Both
LAMA_000406400 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— Both
LAMA_000590700 ⚠
OB-fold nucleic acid binding domain/tRNA synt
— Both
LAMA_000593200 ⚠
GrpE, putative
— Both
LAMA_000384900 ⚠
hypothetical protein, conserved
— Both
LAMA_000186600 ⚠
Pyridoxal-dependent decarboxylase, pyridoxal
— Both
LAMA_000706800 ⚠
hypothetical protein, conserved
— Both
LAMA_000107800 ⚠
hypothetical protein, conserved
— OG7
LAMA_000749800 ⚠
Acyl CoA binding protein, putative
— OG7
LAMA_000264200 ⚠
Acyl CoA binding protein, putative
— OG7
LAMA_000264000 ⚠
Acyl CoA binding protein, putative
— OG7
LAMA_000757900 ⚠
TIP49 P-loop domain/Holliday junction DNA hel
— OG7
LAMA_000530200 ⚠
SET domain containing protein, putative
— OG7
LAMA_000444800 ⚠
SET domain containing protein, putative
— OG7
LAMA_000471700 ⚠
SET domain containing protein, putative
— OG7
LAMA_000739200 ⚠
SET domain containing protein, putative
— OG7
LAMA_000700000 ⚠
SET domain containing protein, putative
— OG7
LAMA_000193200 ⚠
SET domain containing protein, putative
— OG7
LAMA_000444600 ⚠
SET domain containing protein, putative
— OG7
LAMA_000084200 ⚠
SET domain/MYND finger containing protein, pu
— OG7
LAMA_000157800 ⚠
DEAD/DEAH box helicase/Helicase conserved C-t
— OG7
LAMA_000165200 ⚠
FKBP-type peptidyl-prolyl cis-trans isomerase
— OG7
LAMA_000181600 ⚠
Elongation factor Tu GTP binding domain/Elong
— OG7
LAMA_000487100 ⚠
hypothetical protein, conserved
— OG7
LAMA_000069200 ⚠
Cyclin, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.