LAMA_000757900

TIP49 P-loop domain/Holliday junction DNA helicase RuvB P-loop domain/ATPase family associated with various cellular activities (AAA)/TIP49 AAA-lid domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_101792 OG7: OG7_0003574 36 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 36 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000416600 ⚠
DKCLD (NUC011) domain/TruB family pseudouridy
— +1 more Both
LAMA_000749900 ⚠
TIP49 P-loop domain/DnaB-like helicase C term
— Both
LAMA_000694500 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000730600 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000730700 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000063800 ⚠
Biotin-requiring enzyme/e3 binding domain/2-o
— OG7
LAMA_000730800 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000078600 ⚠
Prolyl oligopeptidase, N-terminal beta-propel
— OG7
LAMA_000219700 ⚠
Sodium/hydrogen exchanger family, putative
— OG7
LAMA_000147800 ⚠
Prolyl oligopeptidase, N-terminal beta-propel
— OG7
LAMA_000752000 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000346900 ⚠
Proteasome subunit, putative
— Both
LAMA_000107400 ⚠
Domain of unknown function (DUF4139), putativ
— OG7
LAMA_000236800 ⚠
Cyclic nucleotide-binding domain/PAS fold/Pro
— OG7
LAMA_000195200 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000030200 ⚠
AMP-binding enzyme, putative
— OG7
LAMA_000032500 ⚠
AMP-binding enzyme, putative
— OG7
LAMA_000042700 ⚠
AMP-binding enzyme, putative
— OG7
LAMA_000595600 ⚠
Domain of unknown function (DUF4139), putativ
— OG7
LAMA_000304300 ⚠
Choline/Carnitine o-acyltransferase, putative
— OG7
LAMA_000284100
Protein tyrosine kinase/Protein kinase domain
— OG6
LAMA_000290700 ⚠
Fibrillarin/tRNA methyltransferase complex GC
— Both
LAMA_000193700 ⚠
WD domain, G-beta repeat, putative
— Both
LAMA_000186300 ⚠
tRNA synthetases class I (C) catalytic domain
— Both
LAMA_000236100 ⚠
Bacterial NAD-glutamate dehydrogenase/Glutama
— Both
LAMA_000618800 ⚠
MORN repeat, putative
— Both
LAMA_000608600 ⚠
SET domain containing protein, putative
— Both
LAMA_000662900 ⚠
PheRS DNA binding domain 1/PheRS DNA binding
— Both
LAMA_000730500 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000114700 ⚠
Choline/Carnitine o-acyltransferase, putative
— OG7
LAMA_000420600 ⚠
Choline/Carnitine o-acyltransferase, putative
— OG7
LAMA_000600000 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— OG7
LAMA_000375200 ⚠
Prolyl oligopeptidase, N-terminal beta-propel
— OG7
LAMA_000296700 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000065400 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— OG7
LAMA_000633600 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— OG7
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.