LAMA_000416600

DKCLD (NUC011) domain/TruB family pseudouridylate synthase (N terminal domain)/tRNA pseudouridylate synthase B C-terminal domain/PUA domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100327 OG7: OG7_0003591 20 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 20 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000749900 ⚠
TIP49 P-loop domain/DnaB-like helicase C term
— +3 more Both
LAMA_000757900 ⚠
TIP49 P-loop domain/Holliday junction DNA hel
— +1 more Both
LAMA_000763400 ⚠
Ribosomal protein L7Ae/L30e/S12e/Gadd45 famil
— Both
LAMA_000195200 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000236800 ⚠
Cyclic nucleotide-binding domain/PAS fold/Pro
— OG7
LAMA_000694500 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000192900 ⚠
Protein of unknown function (DUF1698)/Methylt
— OG7
LAMA_000239900 ⚠
Ribosomal protein L7Ae/L30e/S12e/Gadd45 famil
— OG7
LAMA_000241700 ⚠
Ribosomal protein L11 methyltransferase (PrmA
— OG7
LAMA_000016500 ⚠
Conserved hypothetical protein 95/Ribosomal p
— OG7
LAMA_000752000 ⚠
Cyclic nucleotide-binding domain containing p
— Both
LAMA_000063800
Biotin-requiring enzyme/e3 binding domain/2-o
— Both
LAMA_000299400
Phe-tRNA synthetase beta subunit B1 domain/B3
— Both
LAMA_000766500
Gar1/Naf1 RNA binding region containing prote
— Both
LAMA_000309100
Nucleolar RNA-binding protein, Nop10p family,
— Both
LAMA_000046200 ⚠
Methyltransferase domain containing protein,
— Both
LAMA_000784000
Protein kinase domain/Protein tyrosine kinase
— OG6
LAMA_000042700 ⚠
AMP-binding enzyme, putative
— Both
LAMA_000032500 ⚠
AMP-binding enzyme, putative
— Both
LAMA_000030200 ⚠
AMP-binding enzyme, putative
— Both
Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.