LAMA_000375200

Prolyl oligopeptidase, N-terminal beta-propeller domain/Prolyl oligopeptidase family, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_101804 OG7: OG7_0003174 48 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 48 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000527800 ⚠
hypothetical protein, conserved
— OG7
LAMA_000730800 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000619800 ⚠
T-complex protein 11, putative
— OG7
LAMA_000799400 ⚠
Pex19 protein family, putative
— OG7
LAMA_000776200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000595600 ⚠
Domain of unknown function (DUF4139), putativ
— OG7
LAMA_000107400 ⚠
Domain of unknown function (DUF4139), putativ
— OG7
LAMA_000106000 ⚠
Peptidase M1 N-terminal domain/Peptidase fami
— OG7
LAMA_000192700 ⚠
Peptidase M1 N-terminal domain/Peptidase fami
— OG7
LAMA_000065400 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— OG7
LAMA_000771500 ⚠
hypothetical protein, conserved
— OG7
LAMA_000351800 ⚠
Peptidase family M3, putative
— OG7
LAMA_000730700 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000616800 ⚠
tRNA synthetases class I (I, L, M and V)/tRNA
— OG7
LAMA_000732600 ⚠
Deoxyhypusine synthase, putative
— OG7
LAMA_000600000 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— OG7
LAMA_000380800 ⚠
Deoxyhypusine synthase, putative
— OG7
LAMA_000298300 ⚠
CAP-Gly domain containing protein, putative
— OG7
LAMA_000298400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000059600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000633600 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— OG7
LAMA_000345300 ⚠
Anticodon binding domain containing protein,
— OG7
LAMA_000219700 ⚠
Sodium/hydrogen exchanger family, putative
— OG7
LAMA_000203600 ⚠
tRNA synthetases class I (I, L, M and V)/tRNA
— OG7
LAMA_000653200 ⚠
Insulinase (Peptidase family M16)/Peptidase M
— OG7
LAMA_000710000 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG6
LAMA_000356700 ⚠
Initiation factor 2 subunit family, putative
— Both
LAMA_000544900 ⚠
BRO1-like domain/ALIX V-shaped domain binding
— Both
LAMA_000277500 ⚠
Ubiquitin-like domain/CAP-Gly domain containi
— Both
LAMA_000148500 ⚠
Uncharacterised protein family (UPF0160), put
— Both
LAMA_000040500 ⚠
Peptidase family M3, putative
— Both
LAMA_000517300 ⚠
Peptidase family M3, putative
— Both
LAMA_000547400 ⚠
CHAP domain/Glutathionylspermidine synthase p
— Both
LAMA_000118100 ⚠
DinB superfamily/Sulfatase-modifying factor e
— Both
LAMA_000505400 ⚠
Peptidase M1 N-terminal domain/Peptidase fami
— Both
LAMA_000423100 ⚠
tRNA-methyltransferase O, putative
— OG7
LAMA_000303400 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG6
LAMA_000749900 ⚠
TIP49 P-loop domain/DnaB-like helicase C term
— OG7
LAMA_000757900 ⚠
TIP49 P-loop domain/Holliday junction DNA hel
— OG7
LAMA_000042400 ⚠
Aldehyde dehydrogenase family, putative
— OG7
LAMA_000016200 ⚠
Dipeptidyl peptidase IV (DPP IV) N-terminal r
— OG7
LAMA_000502300 ⚠
CHAP domain/Glutathionylspermidine synthase p
— OG7
LAMA_000724900 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000724600 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000521400 ⚠
Methyltransferase domain containing protein,
— OG7
LAMA_000296700 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000730500 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000730600 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.