LAMA_000730700

lactate/malate dehydrogenase, NAD binding domain/lactate/malate dehydrogenase, alpha/beta C-terminal domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_192279 OG7: OG7_0004751 52 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 52 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000055800 ⚠
Spermidine synthase tetramerisation domain/Sp
— OG7
LAMA_000517300 ⚠
Peptidase family M3, putative
— OG7
LAMA_000089400 ⚠
Phosphotyrosyl phosphate activator (PTPA) pro
— OG7
LAMA_000600000 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— OG7
LAMA_000375200 ⚠
Prolyl oligopeptidase, N-terminal beta-propel
— OG7
LAMA_000065400 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— OG7
LAMA_000633600 ⚠
Peptidase family M20/M25/M40/Peptidase dimeri
— OG7
LAMA_000078600 ⚠
Prolyl oligopeptidase, N-terminal beta-propel
— OG7
LAMA_000219700 ⚠
Sodium/hydrogen exchanger family, putative
— OG7
LAMA_000147800 ⚠
Prolyl oligopeptidase, N-terminal beta-propel
— OG7
LAMA_000291300 ⚠
Metallopeptidase family M24, putative
— OG7
LAMA_000199400 ⚠
Metallopeptidase family M24, putative
— OG7
LAMA_000595600 ⚠
Domain of unknown function (DUF4139), putativ
— OG7
LAMA_000107400 ⚠
Domain of unknown function (DUF4139), putativ
— OG7
LAMA_000040500 ⚠
Peptidase family M3, putative
— OG7
LAMA_000757900 ⚠
TIP49 P-loop domain/Holliday junction DNA hel
— OG7
LAMA_000351800 ⚠
Peptidase family M3, putative
— OG7
LAMA_000125700 ⚠
FHA domain containing protein, putative
— OG7
LAMA_000422600 ⚠
FHA domain/Inner membrane component of T3SS,
— OG7
LAMA_000015600 ⚠
UTP--glucose-1-phosphate uridylyltransferase,
— OG7
LAMA_000413600 ⚠
DEAD/DEAH box helicase/Type III restriction e
— OG7
LAMA_000033700 ⚠
DEAD/DEAH box helicase/Helicase conserved C-t
— OG7
LAMA_000433400 ⚠
Calcineurin-like phosphoesterase, putative
— OG7
LAMA_000263600 ⚠
Calcineurin-like phosphoesterase, putative
— OG7
LAMA_000373300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000228800 ⚠
Ecotin, putative
— OG7
LAMA_000230700 ⚠
Ecotin, putative
— OG7
LAMA_000801100 ⚠
Replication factor A protein 3, putative
— OG7
LAMA_000672700 ⚠
TCP-1/cpn60 chaperonin family, putative
— OG7
LAMA_000598700 ⚠
Phosphomethylpyrimidine kinase/pfkB family ca
— OG7
LAMA_000374200 ⚠
Metalloenzyme superfamily/BPG-independent PGA
— OG7
LAMA_000547400 ⚠
CHAP domain/Glutathionylspermidine synthase p
— OG7
LAMA_000425300 ⚠
Oxidoreductase FAD-binding domain/Ferric redu
— OG7
LAMA_000583700 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000724900 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000724600 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000503900 ⚠
Phosphoribosyl transferase domain containing
— OG7
LAMA_000678100 ⚠
Oxidoreductase FAD-binding domain/Oxidoreduct
— OG7
LAMA_000335700 ⚠
ATP-grasp domain/CoA-ligase, putative
— OG7
LAMA_000425200 ⚠
Oxidoreductase FAD-binding domain/Oxidoreduct
— OG7
LAMA_000502300 ⚠
CHAP domain/Glutathionylspermidine synthase p
— OG7
LAMA_000462300 ⚠
Triosephosphate isomerase, putative
— OG7
LAMA_000499500 ⚠
CoA binding domain/Succinyl-CoA ligase like f
— OG7
LAMA_000535900 ⚠
Oxidoreductase FAD-binding domain/Oxidoreduct
— OG7
LAMA_000213400 ⚠
Threonine synthase N terminus, putative
— OG7
LAMA_000100500 ⚠
Inosine-uridine preferring nucleoside hydrola
— OG7
LAMA_000173100 ⚠
Oxidoreductase FAD-binding domain containing
— OG7
LAMA_000518200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000225800 ⚠
Oxidoreductase FAD-binding domain/Ferric redu
— OG7
LAMA_000203200 ⚠
Oxidoreductase FAD-binding domain/Oxidoreduct
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.