LAMA_000055800

Spermidine synthase tetramerisation domain/Spermine/spermidine synthase domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100634 OG7: OG7_0003460 49 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 49 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000730700 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000730600 ⚠
lactate/malate dehydrogenase, NAD binding dom
— Both
LAMA_000730800 ⚠
lactate/malate dehydrogenase, NAD binding dom
— Both
LAMA_000730500 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000296700 ⚠
lactate/malate dehydrogenase, NAD binding dom
— OG7
LAMA_000085900
Protein kinase domain/Protein tyrosine kinase
— OG6
LAMA_000089400
Phosphotyrosyl phosphate activator (PTPA) pro
— Both
LAMA_000230700 ⚠
Ecotin, putative
— Both
LAMA_000549200 ⚠
Amino-transferase class IV, putative
— Both
LAMA_000549700 ⚠
Amino-transferase class IV, putative
— Both
LAMA_000549400
Ribonucleotide reductase, small chain, putati
— Both
LAMA_000213400
Threonine synthase N terminus, putative
— Both
LAMA_000013900
D-isomer specific 2-hydroxyacid dehydrogenase
— Both
LAMA_000342600 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— OG6
LAMA_000260200 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— Both
LAMA_000574400
Ribose/Galactose Isomerase, putative
— Both
LAMA_000374200
Metalloenzyme superfamily/BPG-independent PGA
— Both
LAMA_000433400 ⚠
Calcineurin-like phosphoesterase, putative
— OG7
LAMA_000125700 ⚠
FHA domain containing protein, putative
— OG7
LAMA_000033700 ⚠
DEAD/DEAH box helicase/Helicase conserved C-t
— OG7
LAMA_000228800 ⚠
Ecotin, putative
— OG7
LAMA_000199400 ⚠
Metallopeptidase family M24, putative
— OG7
LAMA_000502300 ⚠
CHAP domain/Glutathionylspermidine synthase p
— OG7
LAMA_000724900 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000724600 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000351800 ⚠
Peptidase family M3, putative
— OG7
LAMA_000032500 ⚠
AMP-binding enzyme, putative
— Both
LAMA_000547400 ⚠
CHAP domain/Glutathionylspermidine synthase p
— Both
LAMA_000508300
hypothetical protein, conserved
— Both
LAMA_000663900
Ubiquitin-conjugating enzyme, putative
— Both
LAMA_000739100
Uracil phosphoribosyltransferase, putative
— Both
LAMA_000100500
Inosine-uridine preferring nucleoside hydrola
— Both
LAMA_000080400
dUTPase, putative
— Both
LAMA_000583700
lactate/malate dehydrogenase, NAD binding dom
— Both
LAMA_000510000
Aspartate-ammonia ligase, putative
— Both
LAMA_000040500 ⚠
Peptidase family M3, putative
— Both
LAMA_000517300 ⚠
Peptidase family M3, putative
— Both
LAMA_000030200 ⚠
AMP-binding enzyme, putative
— Both
LAMA_000291300 ⚠
Metallopeptidase family M24, putative
— Both
LAMA_000042700 ⚠
AMP-binding enzyme, putative
— Both
LAMA_000373300
hypothetical protein, conserved
— Both
LAMA_000501700
Protein kinase domain/Protein tyrosine kinase
— OG6
LAMA_000413600 ⚠
DEAD/DEAH box helicase/Type III restriction e
— Both
LAMA_000084900
DeoC/LacD family aldolase, putative
— Both
LAMA_000080900
Protein kinase domain/Protein tyrosine kinase
— OG6
LAMA_000015600
UTP--glucose-1-phosphate uridylyltransferase,
— Both
LAMA_000263600 ⚠
Calcineurin-like phosphoesterase, putative
— Both
LAMA_000422600 ⚠
FHA domain/Inner membrane component of T3SS,
— Both
LAMA_000598700
Phosphomethylpyrimidine kinase/pfkB family ca
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.