LAMA_000620700

S-adenosylmethionine synthetase, N-terminal domain/S-adenosylmethionine synthetase, central domain/S-adenosylmethionine synthetase, C-terminal domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100388 OG7: OG7_0003674 34 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 34 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000109000 ⚠
Fumarate hydratase (Fumerase)/Fumarase C-term
— Both
LAMA_000211300 ⚠
Inosine-uridine preferring nucleoside hydrola
— Both
LAMA_000239600
Proliferating cell nuclear antigen, N-termina
— Both
LAMA_000032500 ⚠
AMP-binding enzyme, putative
— Both
LAMA_000042700 ⚠
AMP-binding enzyme, putative
— Both
LAMA_000475100
Transketolase, thiamine diphosphate binding d
— Both
LAMA_000261200 ⚠
Dihydrouridine synthase (Dus), putative
— Both
LAMA_000813900 ⚠
Glyceraldehyde 3-phosphate dehydrogenase, NAD
— +1 more Both
LAMA_000456800 ⚠
Fumarate hydratase (Fumerase)/Fumarase C-term
— Both
LAMA_000288700 ⚠
Inosine-uridine preferring nucleoside hydrola
— Both
LAMA_000189200
Phosphoglucose isomerase, putative
— Both
LAMA_000641300 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000740500 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000618000 ⚠
tRNA synthetases class I (E and Q), catalytic
— OG7
LAMA_000310500 ⚠
Dihydrouridine synthase (Dus), putative
— OG7
LAMA_000603100 ⚠
Queuine tRNA-ribosyltransferase, putative
— OG7
LAMA_000358100 ⚠
Aldehyde dehydrogenase family, putative
— OG7
LAMA_000065400
Pyridine nucleotide-disulphide oxidoreductase
— Both
LAMA_000614400 ⚠
Aldehyde dehydrogenase family, putative
— Both
LAMA_000615100 ⚠
Glyceraldehyde 3-phosphate dehydrogenase, NAD
— Both
LAMA_000567600 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— OG6
LAMA_000514000 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— OG6
LAMA_000021200 ⚠
Hsp70 protein, putative
— OG6
LAMA_000583300 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— Both
LAMA_000528900 ⚠
Queuine tRNA-ribosyltransferase, putative
— Both
LAMA_000538200
Acyl-CoA dehydrogenase, N-terminal domain/Acy
— Both
LAMA_000204500
Adenylosuccinate synthetase, putative
— Both
LAMA_000171700
NIF3 (NGG1p interacting factor 3), putative
— Both
LAMA_000616800
tRNA synthetases class I (I, L, M and V)/tRNA
— Both
LAMA_000119300
Amidohydrolase family, putative
— Both
LAMA_000190100
Aminotransferase class I and II, putative
— Both
LAMA_000768100
Pyruvate kinase, barrel domain/Pyruvate kinas
— Both
LAMA_000239500 ⚠
tRNA synthetases class I (E and Q), catalytic
— Both
LAMA_000030200 ⚠
AMP-binding enzyme, putative
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.