LAMA_000119300

Amidohydrolase family, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100650 OG7: OG7_0004147 56 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 56 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000724900 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000461400 ⚠
Malic enzyme, N-terminal domain/Malic enzyme,
— Both
LAMA_000567600 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— Both
LAMA_000514000 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— Both
LAMA_000021200 ⚠
Hsp70 protein, putative
— Both
LAMA_000583300 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— OG6
LAMA_000768100
Pyruvate kinase, barrel domain/Pyruvate kinas
— Both
LAMA_000440100
AMP-binding enzyme/AMP-binding enzyme C-termi
— Both
LAMA_000456800 ⚠
Fumarate hydratase (Fumerase)/Fumarase C-term
— Both
LAMA_000109000 ⚠
Fumarate hydratase (Fumerase)/Fumarase C-term
— Both
LAMA_000148500
Uncharacterised protein family (UPF0160), put
— Both
LAMA_000547400 ⚠
CHAP domain/Glutathionylspermidine synthase p
— Both
LAMA_000189200
Phosphoglucose isomerase, putative
— Both
LAMA_000502300 ⚠
CHAP domain/Glutathionylspermidine synthase p
— OG7
LAMA_000461500 ⚠
Malic enzyme, N-terminal domain/Malic enzyme,
— Both
LAMA_000724600 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000505500 ⚠
Ankyrin repeats (3 copies)/Ankyrin repeats (m
— OG7
LAMA_000101700 ⚠
FYVE zinc finger/3'5'-cyclic nucleotide phosp
— OG7
LAMA_000307100 ⚠
Histidine phosphatase superfamily (branch 1),
— OG7
LAMA_000284200 ⚠
3'5'-cyclic nucleotide phosphodiesterase, put
— OG7
LAMA_000104000 ⚠
3'5'-cyclic nucleotide phosphodiesterase, put
— OG7
LAMA_000268200 ⚠
3'5'-cyclic nucleotide phosphodiesterase, put
— OG7
LAMA_000009700 ⚠
Paraflagellar rod protein, putative
— OG7
LAMA_000031800 ⚠
Hsp70 protein, putative
— OG7
LAMA_000813600 ⚠
Hsp70 protein, putative
— OG7
LAMA_000510500 ⚠
Hsp70 protein, putative
— OG7
LAMA_000286500 ⚠
Hsp70 protein, putative
— OG7
LAMA_000362000 ⚠
Aminopeptidase P, N-terminal domain/Metallope
— OG7
LAMA_000030200 ⚠
AMP-binding enzyme, putative
— Both
LAMA_000615100 ⚠
Glyceraldehyde 3-phosphate dehydrogenase, NAD
— Both
LAMA_000171400
Seryl-tRNA synthetase N-terminal domain/tRNA
— Both
LAMA_000756700
Aldose 1-epimerase, putative
— Both
LAMA_000342600 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— Both
LAMA_000260200 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— OG6
LAMA_000790100 ⚠
Aminopeptidase P, N-terminal domain/Metallope
— Both
LAMA_000547200 ⚠
Paraflagellar rod protein/Variant SH3 domain/
— Both
LAMA_000510000
Aspartate-ammonia ligase, putative
— Both
LAMA_000538200
Acyl-CoA dehydrogenase, N-terminal domain/Acy
— Both
LAMA_000065400
Pyridine nucleotide-disulphide oxidoreductase
— Both
LAMA_000688100
Glucosamine-6-phosphate isomerases/6-phosphog
— Both
LAMA_000240300 ⚠
hypothetical protein, conserved
— Both
LAMA_000620700
S-adenosylmethionine synthetase, N-terminal d
— Both
LAMA_000204500
Adenylosuccinate synthetase, putative
— Both
LAMA_000095800 ⚠
Histidine phosphatase superfamily (branch 1),
— Both
LAMA_000288700 ⚠
Inosine-uridine preferring nucleoside hydrola
— Both
LAMA_000211300 ⚠
Inosine-uridine preferring nucleoside hydrola
— Both
LAMA_000032500 ⚠
AMP-binding enzyme, putative
— Both
LAMA_000240000 ⚠
3'5'-cyclic nucleotide phosphodiesterase, put
— Both
LAMA_000240100 ⚠
hypothetical protein, conserved
— Both
LAMA_000240200 ⚠
3'5'-cyclic nucleotide phosphodiesterase, put
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.