LAMA_000461500

Malic enzyme, N-terminal domain/Malic enzyme, NAD binding domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100205 OG7: OG7_0002857 46 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 46 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000013500 ⚠
M17 aminopeptidase N-terminal domain 2, putat
— OG7
LAMA_000148500 ⚠
Uncharacterised protein family (UPF0160), put
— Both
LAMA_000190100 ⚠
Aminotransferase class I and II, putative
— Both
LAMA_000698500 ⚠
ABC transporter, putative
— Both
LAMA_000653200 ⚠
Insulinase (Peptidase family M16)/Peptidase M
— Both
LAMA_000602000 ⚠
hypothetical protein, conserved
— Both
LAMA_000440100 ⚠
AMP-binding enzyme/AMP-binding enzyme C-termi
— Both
LAMA_000547400 ⚠
CHAP domain/Glutathionylspermidine synthase p
— Both
LAMA_000374200 ⚠
Metalloenzyme superfamily/BPG-independent PGA
— Both
LAMA_000031800 ⚠
Hsp70 protein, putative
— OG7
LAMA_000813600 ⚠
Hsp70 protein, putative
— OG7
LAMA_000510500 ⚠
Hsp70 protein, putative
— OG7
LAMA_000260200 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— OG6
LAMA_000286500 ⚠
Hsp70 protein, putative
— OG7
LAMA_000502300 ⚠
CHAP domain/Glutathionylspermidine synthase p
— OG7
LAMA_000724900 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000724600 ⚠
CHAP domain containing protein, putative
— OG7
LAMA_000009700 ⚠
Paraflagellar rod protein, putative
— OG7
LAMA_000362000 ⚠
Aminopeptidase P, N-terminal domain/Metallope
— OG7
LAMA_000676700 ⚠
Elongation factor Tu GTP binding domain/50S r
— OG7
LAMA_000498900 ⚠
Elongation factor Tu GTP binding domain/Elong
— OG7
LAMA_000297600 ⚠
ABC transporter, putative
— OG7
LAMA_000042000 ⚠
ABC transporter, putative
— OG7
LAMA_000307500 ⚠
Elongation factor Tu GTP binding domain/Elong
— Both
LAMA_000159700 ⚠
Isocitrate/isopropylmalate dehydrogenase, put
— +2 more Both
LAMA_000456800 ⚠
Fumarate hydratase (Fumerase)/Fumarase C-term
— Both
LAMA_000499500 ⚠
CoA binding domain/Succinyl-CoA ligase like f
— Both
LAMA_000461400 ⚠
Malic enzyme, N-terminal domain/Malic enzyme,
— Both
LAMA_000109000 ⚠
Fumarate hydratase (Fumerase)/Fumarase C-term
— Both
LAMA_000280100 ⚠
Citrate synthase, C-terminal domain containin
— Both
LAMA_000059600 ⚠
hypothetical protein, conserved
— Both
LAMA_000221800 ⚠
Enolase, N-terminal domain/Enolase, C-termina
— Both
LAMA_000790100 ⚠
Aminopeptidase P, N-terminal domain/Metallope
— Both
LAMA_000547200 ⚠
Paraflagellar rod protein/Variant SH3 domain/
— Both
LAMA_000335700 ⚠
ATP-grasp domain/CoA-ligase, putative
— Both
LAMA_000800100 ⚠
Shikimate / quinate 5-dehydrogenase/3-hydroxy
— Both
LAMA_000278000 ⚠
Aconitase family (aconitate hydratase)/Aconit
— Both
LAMA_000119300 ⚠
Amidohydrolase family, putative
— Both
LAMA_000799400 ⚠
Pex19 protein family, putative
— Both
LAMA_000510000 ⚠
Aspartate-ammonia ligase, putative
— Both
LAMA_000342600 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— Both
LAMA_000567600 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— Both
LAMA_000721900 ⚠
M17 aminopeptidase N-terminal domain 2/Cytoso
— Both
LAMA_000514000 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— Both
LAMA_000021200 ⚠
Hsp70 protein, putative
— Both
LAMA_000583300 ⚠
Hsp70 protein/MreB/Mbl protein, putative
— OG6
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.