LAMA_000800100

Shikimate / quinate 5-dehydrogenase/3-hydroxyacyl-CoA dehydrogenase, NAD binding domain/NADP oxidoreductase coenzyme F420-dependent/NAD binding domain of 6-phosphogluconate dehydrogenase/6-phosphogluconate dehydrogenase, C-terminal domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100975 OG7: OG7_0005833 26 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 26 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000564200
ATP cone domain/Ribonucleotide reductase, all
— Both
LAMA_000505400 ⚠
Peptidase M1 N-terminal domain/Peptidase fami
— OG7
LAMA_000192700 ⚠
Peptidase M1 N-terminal domain/Peptidase fami
— OG7
LAMA_000228100 ⚠
hypothetical protein, conserved
— OG7
LAMA_000475600
Hydroxymethylglutaryl-coenzyme A synthase N t
— Both
LAMA_000189200
Phosphoglucose isomerase, putative
— Both
LAMA_000109000 ⚠
Fumarate hydratase (Fumerase)/Fumarase C-term
— Both
LAMA_000456800 ⚠
Fumarate hydratase (Fumerase)/Fumarase C-term
— Both
LAMA_000443600 ⚠
Thiolase, N-terminal domain/Beta-ketoacyl syn
— Both
LAMA_000295000
zf-MYND-like zinc finger, mRNA-binding/Metall
— Both
LAMA_000070400
Phosphorylase superfamily, putative
— Both
LAMA_000190100
Aminotransferase class I and II, putative
— Both
LAMA_000617400
Hydroxymethylglutaryl-coenzyme A reductase, p
— Both
LAMA_000159700
Isocitrate/isopropylmalate dehydrogenase, put
— Both
LAMA_000106000 ⚠
Peptidase M1 N-terminal domain/Peptidase fami
— Both
LAMA_000278000
Aconitase family (aconitate hydratase)/Aconit
— Both
LAMA_000065400
Pyridine nucleotide-disulphide oxidoreductase
— Both
LAMA_000246900
Aspartate/ornithine carbamoyltransferase, car
— Both
LAMA_000775400 ⚠
Aminotransferase class I and II, putative
— Both
LAMA_000457300 ⚠
Aminotransferase class I and II, putative
— Both
LAMA_000054500
Lyase/Adenylosuccinate lyase C-terminal, puta
— Both
LAMA_000797400
FGGY family of carbohydrate kinases, N-termin
— Both
LAMA_000221800
Enolase, N-terminal domain/Enolase, C-termina
— Both
LAMA_000461400 ⚠
Malic enzyme, N-terminal domain/Malic enzyme,
— Both
LAMA_000280100
Citrate synthase, C-terminal domain containin
— Both
LAMA_000461500 ⚠
Malic enzyme, N-terminal domain/Malic enzyme,
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.