LAMA_000475600

Hydroxymethylglutaryl-coenzyme A synthase N terminal, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_101064 OG7: OG7_0006553 77 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 77 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000518200
hypothetical protein, conserved
— Both
LAMA_000396800 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000574900 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000033700 ⚠
DEAD/DEAH box helicase/Helicase conserved C-t
— OG7
LAMA_000713100 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000108200 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000425600 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000610900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000788200 ⚠
Adenosine/AMP deaminase, putative
— OG7
LAMA_000228100 ⚠
hypothetical protein, conserved
— OG7
LAMA_000192700 ⚠
Peptidase M1 N-terminal domain/Peptidase fami
— OG7
LAMA_000797400
FGGY family of carbohydrate kinases, N-termin
— Both
LAMA_000800100
Shikimate / quinate 5-dehydrogenase/3-hydroxy
— Both
LAMA_000383500
CTP synthase N-terminus/Glutamine amidotransf
— Both
LAMA_000109000 ⚠
Fumarate hydratase (Fumerase)/Fumarase C-term
— Both
LAMA_000456800 ⚠
Fumarate hydratase (Fumerase)/Fumarase C-term
— Both
LAMA_000443600 ⚠
Thiolase, N-terminal domain/Beta-ketoacyl syn
— Both
LAMA_000434700
AhpC/TSA family/Redoxin/C-terminal domain of
— Both
LAMA_000164800 ⚠
Adenosine/AMP deaminase, putative
— Both
LAMA_000260200 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— Both
LAMA_000504100 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000498900 ⚠
Elongation factor Tu GTP binding domain/Elong
— OG7
LAMA_000676700 ⚠
Elongation factor Tu GTP binding domain/50S r
— OG7
LAMA_000375500 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000108400 ⚠
16S rRNA methyltransferase RsmB/F, putative
— OG7
LAMA_000655200 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000543600 ⚠
Phosphotransferase enzyme family/Choline/etha
— OG7
LAMA_000624900 ⚠
N-terminal domain of 16S rRNA methyltransfera
— OG7
LAMA_000792600 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000801900 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000342600 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— OG6
LAMA_000679200 ⚠
16S rRNA methyltransferase RsmB/F, putative
— OG7
LAMA_000104400 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000498700 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000572100 ⚠
16S rRNA methyltransferase RsmB/F, putative
— OG7
LAMA_000769800 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
LAMA_000789800 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000172900 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000505400 ⚠
Peptidase M1 N-terminal domain/Peptidase fami
— OG7
LAMA_000402900 ⚠
hypothetical protein, conserved
— Both
LAMA_000703200 ⚠
NLI interacting factor-like phosphatase, puta
— Both
LAMA_000705600 ⚠
hypothetical protein, conserved
— Both
LAMA_000307500 ⚠
Elongation factor Tu GTP binding domain/Elong
— Both
LAMA_000335700
ATP-grasp domain/CoA-ligase, putative
— Both
LAMA_000510000
Aspartate-ammonia ligase, putative
— Both
LAMA_000246900
Aspartate/ornithine carbamoyltransferase, car
— Both
LAMA_000279600 ⚠
Protein kinase domain/Protein tyrosine kinase
— Both
LAMA_000413600 ⚠
DEAD/DEAH box helicase/Type III restriction e
— Both
LAMA_000097400 ⚠
Protein kinase domain/Protein tyrosine kinase
— Both
LAMA_000499300
KIF-1 binding protein C terminal, putative
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.