LAMA_000617400

Hydroxymethylglutaryl-coenzyme A reductase, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_101762 OG7: OG7_0005934 15 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 15 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000280100
Citrate synthase, C-terminal domain containin
— Both
LAMA_000493500
Predicted ATPase of the ABC class, putative
— Both
LAMA_000134500
Domain found in IF2B/IF5, putative
— Both
LAMA_000092400
AARP2CN (NUC121) domain/40S ribosome biogenes
— Both
LAMA_000545600
eRF1 domain 1/Bacterial archaeo-eukaryotic re
— Both
LAMA_000353200
hypothetical protein, conserved
— Both
LAMA_000246900
Aspartate/ornithine carbamoyltransferase, car
— Both
LAMA_000065400
Pyridine nucleotide-disulphide oxidoreductase
— Both
LAMA_000510200
hypothetical protein, conserved
— Both
LAMA_000800100
Shikimate / quinate 5-dehydrogenase/3-hydroxy
— Both
LAMA_000248400 ⚠
Endonuclease/Exonuclease/phosphatase family,
— Both
LAMA_000105300
Enoyl-CoA hydratase/isomerase, putative
— Both
LAMA_000391600
hypothetical protein, conserved
— Both
LAMA_000105400
Variant UBP zinc finger/Zn-finger in ubiquiti
— Both
LAMA_000359000 ⚠
Endonuclease/Exonuclease/phosphatase family,
— OG7
Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.