LAMA_000749000

Guanine nucleotide exchange factor in Golgi transport N-terminal/Sec7 domain/Domain of unknown function (DUF1981), putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_154458 OG7: OG7_0001170 164 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 164 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000057000 ⚠
Axonemal dynein light chain, putative
— OG7
LAMA_000035200 ⚠
Phosphatidylinositol 3- and 4-kinase, putativ
— OG7
LAMA_000299100 ⚠
WD domain, G-beta repeat, putative
— OG7
LAMA_000579000 ⚠
WW domain containing protein, putative
— OG7
LAMA_000762800 ⚠
Domain of unknown function (DUF3385)/FAT doma
— OG7
LAMA_000453900 ⚠
Beige/BEACH domain containing protein, putati
— OG7
LAMA_000694500 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000388600 ⚠
FAT domain/Phosphatidylinositol 3- and 4-kina
— OG7
LAMA_000377800 ⚠
Eukaryotic translation initiation factor 3 su
— OG7
LAMA_000435500 ⚠
Beige/BEACH domain containing protein, putati
— OG7
LAMA_000207800 ⚠
SPRY domain/HECT-domain (ubiquitin-transferas
— OG7
LAMA_000166900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000257100 ⚠
WD domain, G-beta repeat, putative
— OG7
LAMA_000217900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000335600 ⚠
Phosphatidylinositol 3- and 4-kinase, putativ
— OG7
LAMA_000407500 ⚠
Axonemal dynein light chain, putative
— OG7
LAMA_000474000 ⚠
hypothetical protein, conserved
— OG7
LAMA_000065900 ⚠
Tetratricopeptide repeat, putative
— OG7
LAMA_000401000 ⚠
hypothetical protein, conserved
— OG7
LAMA_000184900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000128800 ⚠
AAA ATPase domain/RecF/RecN/SMC N terminal do
— OG7
LAMA_000236800 ⚠
Cyclic nucleotide-binding domain/PAS fold/Pro
— OG7
LAMA_000277500 ⚠
Ubiquitin-like domain/CAP-Gly domain containi
— OG7
LAMA_000377600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000355600 ⚠
WD domain, G-beta repeat, putative
— OG7
LAMA_000219200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000166000 ⚠
Initiation factor 2 subunit family, putative
— OG7
LAMA_000766700 ⚠
WD domain, G-beta repeat/Coatomer WD associat
— OG7
LAMA_000741600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000116000 ⚠
hypothetical protein, conserved
— OG7
LAMA_000195200 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000262000 ⚠
hypothetical protein, conserved
— OG7
LAMA_000153100 ⚠
ATPase family associated with various cellula
— OG7
LAMA_000237000 ⚠
Endonuclease/Exonuclease/phosphatase family/R
— OG7
LAMA_000218600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000370200 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LAMA_000290700 ⚠
Fibrillarin/tRNA methyltransferase complex GC
— OG7
LAMA_000232600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000055300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000494200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000493800 ⚠
ER-Golgi trafficking TRAPP I complex 85 kDa s
— OG7
LAMA_000737500 ⚠
hypothetical protein, conserved
— OG7
LAMA_000127800 ⚠
hypothetical protein, conserved
— OG7
LAMA_000456400 ⚠
WD domain, G-beta repeat, putative
— OG7
LAMA_000722600 ⚠
hypothetical protein, conserved
— OG7
LAMA_000464300 ⚠
AKAP7 2'5' RNA ligase-like domain containing
— OG7
LAMA_000221400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000484500 ⚠
Raptor N-terminal CASPase like domain contain
— OG7
LAMA_000270300 ⚠
XRN 5'-3' exonuclease N-terminus/Xrn1 helical
— OG7
LAMA_000632200 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.