LAMA_000762800

Domain of unknown function (DUF3385)/FAT domain/FKBP12-rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase/FATC domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_138996 OG7: OG7_0001934 296 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 296 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000110500 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— OG7
LAMA_000710500 ⚠
hypothetical protein, conserved
— Both
LAMA_000648100 ⚠
FAD dependent oxidoreductase/Pyridine nucleot
— +1 more Both
LAMA_000648200 ⚠
HI0933-like protein/Pyridine nucleotide-disul
— Both
LAMA_000683600 ⚠
CS domain containing protein, putative
— Both
LAMA_000358700 ⚠
Glycosyl hydrolase family 65, N-terminal doma
— Both
LAMA_000253800 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000512400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000706700 ⚠
hypothetical protein, conserved
— OG7
LAMA_000569900 ⚠
Holliday junction DNA helicase RuvB P-loop do
— OG7
LAMA_000440400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000407500 ⚠
Axonemal dynein light chain, putative
— OG7
LAMA_000707400 ⚠
Axonemal dynein light chain, putative
— OG7
LAMA_000462200 ⚠
Axonemal dynein light chain, putative
— OG7
LAMA_000512800 ⚠
Axonemal dynein light chain, putative
— OG7
LAMA_000199400 ⚠
Metallopeptidase family M24, putative
— OG7
LAMA_000291300 ⚠
Metallopeptidase family M24, putative
— OG7
LAMA_000059100 ⚠
Adenylate kinase/AAA domain containing protei
— OG7
LAMA_000241600 ⚠
Holliday junction DNA helicase RuvB P-loop do
— OG7
LAMA_000319700 ⚠
AAA domain/Adenylate kinase, putative
— OG7
LAMA_000197500 ⚠
DEAD/DEAH box helicase/Type III restriction e
— OG7
LAMA_000267800 ⚠
N-terminal helicase PWI domain/DEAD/DEAH box
— OG7
LAMA_000668200 ⚠
DEAD/DEAH box helicase/Type III restriction e
— OG7
LAMA_000450700 ⚠
DEAD/DEAH box helicase/Helicase conserved C-t
— OG7
LAMA_000667700 ⚠
hypothetical protein
— OG7
LAMA_000410500 ⚠
Adenylate kinase/AAA domain containing protei
— OG7
LAMA_000647800 ⚠
RNA polymerase Rpb1, domain 1/RNA polymerase
— OG7
LAMA_000453900 ⚠
Beige/BEACH domain containing protein, putati
— OG7
LAMA_000724100 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LAMA_000732900 ⚠
RNA polymerase Rpb1, domain 1/RNA polymerase
— OG7
LAMA_000323700 ⚠
PH domain associated with Beige/BEACH/Beige/B
— OG7
LAMA_000625300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000591000 ⚠
hypothetical protein, conserved
— OG7
LAMA_000094900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000507300 ⚠
Cid1 family poly A polymerase, putative
— OG7
LAMA_000347000 ⚠
Nucleotidyltransferase domain containing prot
— OG7
LAMA_000277500 ⚠
Ubiquitin-like domain/CAP-Gly domain containi
— OG7
LAMA_000298400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000262000 ⚠
hypothetical protein, conserved
— OG7
LAMA_000298300 ⚠
CAP-Gly domain containing protein, putative
— OG7
LAMA_000477400 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000576100 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000668900 ⚠
Microtubule-binding protein MIP-T3 CH-like do
— OG7
LAMA_000578900 ⚠
MCM OB domain/MCM P-loop domain/Magnesium che
— OG7
LAMA_000723300 ⚠
MCM N-terminal domain/MCM OB domain/MCM P-loo
— OG7
LAMA_000462900 ⚠
MCM N-terminal domain/MCM OB domain/MCM P-loo
— OG7
LAMA_000414200 ⚠
Microtubule-binding protein MIP-T3 CH-like do
— OG7
LAMA_000057000 ⚠
Axonemal dynein light chain, putative
— OG7
LAMA_000103800 ⚠
Ribosomal protein L13e, putative
— OG7
LAMA_000142100 ⚠
MCM N-terminal domain/MCM OB domain/MCM P-loo
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.