LAMA_000648100

FAD dependent oxidoreductase/Pyridine nucleotide-disulphide oxidoreductase/Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_158283 OG7: OG7_0001633 111 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 111 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000484600 ⚠
RNA polymerase beta subunit/RNA polymerase Rp
— Both
LAMA_000378400 ⚠
RNA polymerase beta subunit/RNA polymerase Rp
— OG7
LAMA_000624500 ⚠
RNA polymerase beta subunit/RNA polymerase Rp
— OG7
LAMA_000110500 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— +1 more Both
LAMA_000767100 ⚠
Domain of unknown function (DUF3385)/FAT doma
— OG7
LAMA_000648200 ⚠
HI0933-like protein/Pyridine nucleotide-disul
— +2 more Both
LAMA_000370000 ⚠
Domain of unknown function (DUF3385)/FAT doma
— OG7
LAMA_000668800 ⚠
FAT domain/Phosphatidylinositol 3- and 4-kina
— OG7
LAMA_000035200 ⚠
Phosphatidylinositol 3- and 4-kinase, putativ
— OG7
LAMA_000388600 ⚠
FAT domain/Phosphatidylinositol 3- and 4-kina
— OG7
LAMA_000335600 ⚠
Phosphatidylinositol 3- and 4-kinase, putativ
— OG7
LAMA_000762800 ⚠
Domain of unknown function (DUF3385)/FAT doma
— +1 more Both
LAMA_000608200 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000475500 ⚠
hypothetical protein, conserved
— Both
LAMA_000245300 ⚠
Tubulin-tyrosine ligase family, putative
— Both
LAMA_000634500 ⚠
Protein of unknown function (DUF3638)/Protein
— Both
LAMA_000435500 ⚠
Beige/BEACH domain containing protein, putati
— Both
LAMA_000574500 ⚠
hypothetical protein, conserved
— Both
LAMA_000267900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000582700 ⚠
WD domain, G-beta repeat/Eukaryotic translati
— OG7
LAMA_000809900 ⚠
PIH1 N-terminal domain/PIH1 CS-like domain co
— OG7
LAMA_000311800 ⚠
WD domain, G-beta repeat, putative
— OG7
LAMA_000011500 ⚠
WD domain, G-beta repeat/Eukaryotic translati
— OG7
LAMA_000005300 ⚠
WD domain, G-beta repeat, putative
— OG7
LAMA_000684700 ⚠
MCM N-terminal domain/MCM OB domain/MCM P-loo
— OG7
LAMA_000815500 ⚠
MCM OB domain/MCM P-loop domain/MCM AAA-lid d
— OG7
LAMA_000065200 ⚠
MCM OB domain/MCM P-loop domain/AAA domain (d
— OG7
LAMA_000142100 ⚠
MCM N-terminal domain/MCM OB domain/MCM P-loo
— OG7
LAMA_000578900 ⚠
MCM OB domain/MCM P-loop domain/Magnesium che
— OG7
LAMA_000723300 ⚠
MCM N-terminal domain/MCM OB domain/MCM P-loo
— OG7
LAMA_000462900 ⚠
MCM N-terminal domain/MCM OB domain/MCM P-loo
— OG7
LAMA_000576100 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000079700 ⚠
SpoU rRNA Methylase family, putative
— OG7
LAMA_000180100 ⚠
Adaptin N terminal region/non-SMC mitotic con
— OG7
LAMA_000375400 ⚠
Adaptin N terminal region/HEAT repeats/non-SM
— OG7
LAMA_000149100 ⚠
Ubiquitin-2 like Rad60 SUMO-like/Ubiquitin fa
— OG7
LAMA_000470800 ⚠
SpoU rRNA Methylase family, putative
— OG7
LAMA_000247300 ⚠
Carbamoyl-phosphate synthase small chain, CPS
— OG7
LAMA_000647800 ⚠
RNA polymerase Rpb1, domain 1/RNA polymerase
— OG7
LAMA_000453900 ⚠
Beige/BEACH domain containing protein, putati
— OG7
LAMA_000724100 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LAMA_000732900 ⚠
RNA polymerase Rpb1, domain 1/RNA polymerase
— OG7
LAMA_000323700 ⚠
PH domain associated with Beige/BEACH/Beige/B
— OG7
LAMA_000768300 ⚠
Transketolase, pyrimidine binding domain/Tran
— OG7
LAMA_000477400 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000385200 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000276500 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000684500 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000126100 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000276600 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.