LAMA_000648200

HI0933-like protein/Pyridine nucleotide-disulphide oxidoreductase/FAD binding domain/FAD dependent oxidoreductase/Glucose inhibited division protein A/Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_148301 OG7: OG7_0001633 112 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 112 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000110500 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— +1 more Both
LAMA_000335600 ⚠
Phosphatidylinositol 3- and 4-kinase, putativ
— OG7
LAMA_000388600 ⚠
FAT domain/Phosphatidylinositol 3- and 4-kina
— OG7
LAMA_000035200 ⚠
Phosphatidylinositol 3- and 4-kinase, putativ
— OG7
LAMA_000668800 ⚠
FAT domain/Phosphatidylinositol 3- and 4-kina
— OG7
LAMA_000370000 ⚠
Domain of unknown function (DUF3385)/FAT doma
— OG7
LAMA_000767100 ⚠
Domain of unknown function (DUF3385)/FAT doma
— OG7
LAMA_000484600 ⚠
RNA polymerase beta subunit/RNA polymerase Rp
— OG7
LAMA_000624500 ⚠
RNA polymerase beta subunit/RNA polymerase Rp
— Both
LAMA_000378400 ⚠
RNA polymerase beta subunit/RNA polymerase Rp
— Both
LAMA_000762800 ⚠
Domain of unknown function (DUF3385)/FAT doma
— Both
LAMA_000648100 ⚠
FAD dependent oxidoreductase/Pyridine nucleot
— +2 more Both
LAMA_000175100 ⚠
hypothetical protein, conserved
— OG7
LAMA_000174400 ⚠
Tubulin-tyrosine ligase family, putative
— OG7
LAMA_000487900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000433700 ⚠
CAF1 family ribonuclease, putative
— OG7
LAMA_000019300 ⚠
Cullin family, putative
— OG7
LAMA_000253800 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000016100 ⚠
Cullin protein neddylation domain containing
— OG7
LAMA_000336900 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000576100 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000477400 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000019100 ⚠
PRP38 family, putative
— OG7
LAMA_000475500 ⚠
hypothetical protein, conserved
— OG7
LAMA_000323700 ⚠
PH domain associated with Beige/BEACH/Beige/B
— OG7
LAMA_000732900 ⚠
RNA polymerase Rpb1, domain 1/RNA polymerase
— OG7
LAMA_000724100 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LAMA_000255000 ⚠
RNA polymerase Rpb1, domain 2/RNA polymerase
— OG7
LAMA_000453900 ⚠
Beige/BEACH domain containing protein, putati
— OG7
LAMA_000647800 ⚠
RNA polymerase Rpb1, domain 1/RNA polymerase
— OG7
LAMA_000435500 ⚠
Beige/BEACH domain containing protein, putati
— OG7
LAMA_000281500 ⚠
WD domain, G-beta repeat/Dip2/Utp12 Family, p
— OG7
LAMA_000247900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000174100 ⚠
hypothetical protein, conserved
— OG7
LAMA_000093300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000278600 ⚠
Flagellar-associated PapD-like, putative
— OG7
LAMA_000005200 ⚠
Carboxyl transferase domain containing protei
— Both
LAMA_000326900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000334100 ⚠
hypothetical protein, conserved
— OG7
LAMA_000722200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000349300 ⚠
Anaphase-promoting complex subunit 4 WD40 dom
— OG7
LAMA_000681500 ⚠
SpoU rRNA Methylase family, putative
— OG7
LAMA_000356900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000358900 ⚠
Adaptin N terminal region/non-SMC mitotic con
— OG7
LAMA_000687200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000655600 ⚠
Armadillo/beta-catenin-like repeat, putative
— OG7
LAMA_000375400 ⚠
Adaptin N terminal region/HEAT repeats/non-SM
— OG7
LAMA_000149100 ⚠
Ubiquitin-2 like Rad60 SUMO-like/Ubiquitin fa
— OG7
LAMA_000764500 ⚠
GRIP domain containing protein, putative
— OG7
LAMA_000744600 ⚠
Ubiquitin-2 like Rad60 SUMO-like/Ubiquitin fa
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.