LAMA_000732900

RNA polymerase Rpb1, domain 1/RNA polymerase Rpb1, domain 2/RNA polymerase Rpb1, domain 3/RNA polymerase Rpb1, domain 4/RNA polymerase Rpb1, domain 5, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100210 OG7: OG7_0001854 166 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 166 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000295900 ⚠
RNA polymerase Rpb3/Rpb11 dimerisation domain
— +2 more Both
LAMA_000652000 ⚠
Biotin carboxylase, N-terminal domain/Carbamo
— Both
LAMA_000138300 ⚠
N-terminal domain of ribose phosphate pyropho
— Both
LAMA_000133900 ⚠
N-terminal domain of ribose phosphate pyropho
— Both
LAMA_000127300 ⚠
RNA polymerase Rpb3/Rpb11 dimerisation domain
— +1 more Both
LAMA_000378400 ⚠
RNA polymerase beta subunit/RNA polymerase Rp
— +4 more Both
LAMA_000624500 ⚠
RNA polymerase beta subunit/RNA polymerase Rp
— +4 more Both
LAMA_000484600 ⚠
RNA polymerase beta subunit/RNA polymerase Rp
— +1 more OG7
LAMA_000715600 ⚠
N-terminal domain of ribose phosphate pyropho
— OG7
LAMA_000360300 ⚠
N-terminal domain of ribose phosphate pyropho
— OG7
LAMA_000358900 ⚠
Adaptin N terminal region/non-SMC mitotic con
— OG7
LAMA_000093300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000326900 ⚠
hypothetical protein, conserved
— OG7
LAMA_000481000 ⚠
hypothetical protein, conserved
— OG7
LAMA_000744600 ⚠
Ubiquitin-2 like Rad60 SUMO-like/Ubiquitin fa
— OG7
LAMA_000588300 ⚠
Ubiquitin carboxyl-terminal hydrolase/Exonucl
— OG7
LAMA_000751700 ⚠
RNA-binding signal recognition particle 68, p
— OG7
LAMA_000622600 ⚠
CPSF A subunit region containing protein, put
— OG7
LAMA_000668800 ⚠
FAT domain/Phosphatidylinositol 3- and 4-kina
— OG7
LAMA_000764500 ⚠
GRIP domain containing protein, putative
— OG7
LAMA_000687200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000578900 ⚠
MCM OB domain/MCM P-loop domain/Magnesium che
— OG7
LAMA_000576100 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000809200 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000375400 ⚠
Adaptin N terminal region/HEAT repeats/non-SM
— OG7
LAMA_000648100 ⚠
FAD dependent oxidoreductase/Pyridine nucleot
— OG7
LAMA_000724100 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LAMA_000634500 ⚠
Protein of unknown function (DUF3638)/Protein
— OG7
LAMA_000655600 ⚠
Armadillo/beta-catenin-like repeat, putative
— OG7
LAMA_000706700 ⚠
hypothetical protein, conserved
— OG7
LAMA_000569900 ⚠
Holliday junction DNA helicase RuvB P-loop do
— OG7
LAMA_000440400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000648200 ⚠
HI0933-like protein/Pyridine nucleotide-disul
— OG7
LAMA_000512400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000035200 ⚠
Phosphatidylinositol 3- and 4-kinase, putativ
— OG7
LAMA_000298800 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000563800 ⚠
Mini-chromosome maintenance protein 2/MCM N-t
— OG7
LAMA_000762800 ⚠
Domain of unknown function (DUF3385)/FAT doma
— OG7
LAMA_000801700 ⚠
FYVE zinc finger containing protein, putative
— OG7
LAMA_000453900 ⚠
Beige/BEACH domain containing protein, putati
— OG7
LAMA_000791400 ⚠
hypothetical protein, conserved
— OG7
LAMA_000388600 ⚠
FAT domain/Phosphatidylinositol 3- and 4-kina
— OG7
LAMA_000435500 ⚠
Beige/BEACH domain containing protein, putati
— OG7
LAMA_000723300 ⚠
MCM N-terminal domain/MCM OB domain/MCM P-loo
— OG7
LAMA_000477400 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000462900 ⚠
MCM N-terminal domain/MCM OB domain/MCM P-loo
— OG7
LAMA_000241600 ⚠
Holliday junction DNA helicase RuvB P-loop do
— OG7
LAMA_000298500 ⚠
hypothetical protein, conserved
— OG7
LAMA_000514200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000128800 ⚠
AAA ATPase domain/RecF/RecN/SMC N terminal do
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.