LAMA_000358700

Glycosyl hydrolase family 65, N-terminal domain/Glycosyl hydrolase family 65 central catalytic domain/Glycosyl hydrolase family 65, C-terminal domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_103857 OG7: OG7_0008824 152 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 152 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000370000 ⚠
Domain of unknown function (DUF3385)/FAT doma
— OG7
LAMA_000767100 ⚠
Domain of unknown function (DUF3385)/FAT doma
— OG7
LAMA_000668800 ⚠
FAT domain/Phosphatidylinositol 3- and 4-kina
— OG7
LAMA_000634500
Protein of unknown function (DUF3638)/Protein
— Both
LAMA_000035200 ⚠
Phosphatidylinositol 3- and 4-kinase, putativ
— OG7
LAMA_000388600 ⚠
FAT domain/Phosphatidylinositol 3- and 4-kina
— OG7
LAMA_000746000
Glycosyl hydrolase family 65 central catalyti
— Both
LAMA_000335600 ⚠
Phosphatidylinositol 3- and 4-kinase, putativ
— Both
LAMA_000762800 ⚠
Domain of unknown function (DUF3385)/FAT doma
— Both
LAMA_000281400
hypothetical protein, conserved
— +2 more Both
LAMA_000319700 ⚠
AAA domain/Adenylate kinase, putative
— OG7
LAMA_000375400 ⚠
Adaptin N terminal region/HEAT repeats/non-SM
— OG7
LAMA_000180100 ⚠
Adaptin N terminal region/non-SMC mitotic con
— OG7
LAMA_000715600 ⚠
N-terminal domain of ribose phosphate pyropho
— OG7
LAMA_000360300 ⚠
N-terminal domain of ribose phosphate pyropho
— OG7
LAMA_000138300 ⚠
N-terminal domain of ribose phosphate pyropho
— OG7
LAMA_000110500 ⚠
Pyridine nucleotide-disulphide oxidoreductase
— OG7
LAMA_000297600 ⚠
ABC transporter, putative
— OG7
LAMA_000698500 ⚠
ABC transporter, putative
— OG7
LAMA_000809900 ⚠
PIH1 N-terminal domain/PIH1 CS-like domain co
— OG7
LAMA_000777200 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000493900 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG7
LAMA_000546300 ⚠
Protein tyrosine kinase/Fungal protein kinase
— OG7
LAMA_000061800 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000620400 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG7
LAMA_000753600 ⚠
Protein kinase domain containing protein, put
— OG7
LAMA_000253800 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000016100 ⚠
Cullin protein neddylation domain containing
— OG7
LAMA_000336900 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000576100 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000477400 ⚠
Cullin family/Cullin protein neddylation doma
— OG7
LAMA_000347000 ⚠
Nucleotidyltransferase domain containing prot
— OG7
LAMA_000507300 ⚠
Cid1 family poly A polymerase, putative
— OG7
LAMA_000054900 ⚠
Nucleotidyltransferase domain containing prot
— OG7
LAMA_000732900 ⚠
RNA polymerase Rpb1, domain 1/RNA polymerase
— OG7
LAMA_000323700 ⚠
PH domain associated with Beige/BEACH/Beige/B
— OG7
LAMA_000724100 ⚠
Concanavalin A-like lectin/glucanases superfa
— OG7
LAMA_000453900 ⚠
Beige/BEACH domain containing protein, putati
— OG7
LAMA_000647800 ⚠
RNA polymerase Rpb1, domain 1/RNA polymerase
— OG7
LAMA_000555800 ⚠
hypothetical protein, conserved
— OG7
LAMA_000293700 ⚠
Transcription factor S-II (TFIIS), putative
— OG7
LAMA_000011500 ⚠
WD domain, G-beta repeat/Eukaryotic translati
— OG7
LAMA_000427800 ⚠
Kelch motif containing protein, putative
— OG7
LAMA_000458300 ⚠
Kelch motif/Galactose oxidase, central domain
— OG7
LAMA_000470800 ⚠
SpoU rRNA Methylase family, putative
— OG7
LAMA_000005300 ⚠
WD domain, G-beta repeat, putative
— OG7
LAMA_000582700 ⚠
WD domain, G-beta repeat/Eukaryotic translati
— OG7
LAMA_000514200 ⚠
hypothetical protein, conserved
— OG7
LAMA_000221900 ⚠
FYVE zinc finger/Ras family, putative
— OG7
LAMA_000079700 ⚠
SpoU rRNA Methylase family, putative
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.