LAMA_000346000

S-adenosyl-L-homocysteine hydrolase/S-adenosyl-L-homocysteine hydrolase, NAD binding domain/D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain/Acetohydroxy acid isomeroreductase, NADPH-binding domain containing protein, putative
Leishmania amazonensis MHOM/BR/71973/M2269 OG6: OG6_100715 OG7: OG7_0003269 42 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 42 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LAMA_000398600 ⚠
Insulinase (Peptidase family M16), putative
— OG7
LAMA_000435400
MobA-like NTP transferase domain/Nucleotidyl
— Both
LAMA_000138300 ⚠
N-terminal domain of ribose phosphate pyropho
— Both
LAMA_000078900
Glutamine synthetase, beta-Grasp domain/Gluta
— Both
LAMA_000214400 ⚠
Cys/Met metabolism PLP-dependent enzyme, puta
— Both
LAMA_000072200
Rhodanese-like domain/Domain of unknown funct
— Both
LAMA_000042400
Aldehyde dehydrogenase family, putative
— Both
LAMA_000722400 ⚠
Peptidase M16 inactive domain containing prot
— Both
LAMA_000486000
Protein phosphatase 2C, putative
— OG6
LAMA_000330400
Aminotransferase class I and II, putative
— Both
LAMA_000201300 ⚠
hypothetical protein, conserved
— OG7
LAMA_000437900
Vacuolar (H+)-ATPase G subunit, putative
— Both
LAMA_000752000 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000694500 ⚠
Cyclic nucleotide-binding domain containing p
— OG7
LAMA_000236800 ⚠
Cyclic nucleotide-binding domain/PAS fold/Pro
— OG7
LAMA_000715600 ⚠
N-terminal domain of ribose phosphate pyropho
— OG7
LAMA_000360300 ⚠
N-terminal domain of ribose phosphate pyropho
— OG7
LAMA_000618000 ⚠
tRNA synthetases class I (E and Q), catalytic
— OG7
LAMA_000133900 ⚠
N-terminal domain of ribose phosphate pyropho
— OG7
LAMA_000351800 ⚠
Peptidase family M3, putative
— OG7
LAMA_000537300
WD domain, G-beta repeat, putative
— OG7
LAMA_000180200
Pyruvate phosphate dikinase, PEP/pyruvate bin
— Both
LAMA_000260200 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— Both
LAMA_000592200
Cytochrome b5-like Heme/Steroid binding domai
— OG6
LAMA_000303400 ⚠
Protein kinase domain/Protein tyrosine kinase
— OG6
LAMA_000096500
Phosphoglucomutase/phosphomannomutase, alpha/
— Both
LAMA_000710000 ⚠
Protein tyrosine kinase/Protein kinase domain
— OG6
LAMA_000040500 ⚠
Peptidase family M3, putative
— Both
LAMA_000517300 ⚠
Peptidase family M3, putative
— Both
LAMA_000337300
ATP synthase (E/31 kDa) subunit, putative
— Both
LAMA_000324100
Aldehyde dehydrogenase family, putative
— Both
LAMA_000579400
ATP synthase alpha/beta family, beta-barrel d
— Both
LAMA_000342600 ⚠
Pyridoxal-phosphate dependent enzyme, putativ
— OG6
LAMA_000195200 ⚠
Cyclic nucleotide-binding domain containing p
— Both
LAMA_000729900
Glucose-6-phosphate dehydrogenase, NAD bindin
— Both
LAMA_000719600
Polysaccharide biosynthesis protein/NAD depen
— Both
LAMA_000239500 ⚠
tRNA synthetases class I (E and Q), catalytic
— Both
LAMA_000760000
ATP synthase alpha/beta family, beta-barrel d
— Both
LAMA_000503100
Glycine cleavage system P-protein, putative
— Both
LAMA_000799000 ⚠
Cys/Met metabolism PLP-dependent enzyme/DegT/
— Both
LAMA_000236100
Bacterial NAD-glutamate dehydrogenase/Glutama
— Both
LAMA_000434700
AhpC/TSA family/Redoxin/C-terminal domain of
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.