LTRL590_080014700

phosphoribosylpyrophosphate synthetase
Leishmania tropica L590 OG6: OG6_143547 OG7: OG7_0002319 176 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 176 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
LTRL590_310043600 ⚠
acetyl-CoA carboxylase, putative
— +5 more Both
LTRL590_310043700 ⚠
Carbamoyl-phosphate synthase L chain, N-termi
— +5 more Both
LTRL590_080010500 ⚠
ribose-phosphate pyrophosphokinase, putative
— +4 more Both
LTRL590_360065700 ⚠
phosphoribosylpyrophosphate synthetase, putat
— +6 more Both
LTRL590_330026700 ⚠
phosphoribosylpyrophosphate synthetase, putat
— +6 more Both
LTRL590_160020500 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
LTRL590_340008800 ⚠
RNA polymerase ii largest subunit
— Both
LTRL590_310039200 ⚠
RNA polymerase ii largest subunit
— Both
LTRL590_000028500 ⚠
RNA polymerase ii largest subunit
— Both
LTRL590_310039100 ⚠
RNA polymerase ii largest subunit
— Both
LTRL590_120007200 ⚠
ubiquitin hydrolase, putative
— OG7
LTRL590_300030200 ⚠
hypothetical protein, conserved
— OG7
LTRL590_200005000 ⚠
DNA-directed RNA polymerase polypeptide, puta
— OG7
LTRL590_310019500 ⚠
Ubiquitin homologues, putative
— OG7
LTRL590_230027000 ⚠
neutral sphingomyelinase activation associate
— OG7
LTRL590_150012500 ⚠
hypothetical protein, conserved
— OG7
LTRL590_130008900 ⚠
ATP-dependent RNA helicase, putative
— OG7
LTRL590_320012900 ⚠
hypothetical protein, conserved
— OG7
LTRL590_350027900 ⚠
hypothetical protein, conserved
— OG7
LTRL590_290006600 ⚠
DNA-directed RNA polymerase I-like protein
— OG7
LTRL590_340045100 ⚠
target of rapamycin kinase (TOR) kinase 3
— OG7
LTRL590_350030200 ⚠
hypothetical protein, conserved
— OG7
LTRL590_350041200 ⚠
zinc finger protein, putative
— OG7
LTRL590_020006000 ⚠
phosphatidylinositol kinase related protein,
— OG7
LTRL590_300044000 ⚠
CPSF-domain protein, putative
— OG7
LTRL590_360032400 ⚠
Cullin protein neddylation domain containing
— OG7
LTRL590_360081400 ⚠
beta-adaptin, putative
— OG7
LTRL590_100006500 ⚠
Chromatin assembly factor 1 subunit A, putati
— OG7
LTRL590_240030500 ⚠
cullin-like protein-like protein
— OG7
LTRL590_190013800 ⚠
FYVE zinc finger containing protein, putative
— OG7
LTRL590_310006300 ⚠
DNA-directed RNA polymerase polypeptide, puta
— OG7
LTRL590_330009000 ⚠
ATP-binding cassette sub-family F member 1, p
— OG7
LTRL590_290026000 ⚠
hypothetical protein, conserved
— OG7
LTRL590_360040100 ⚠
cullin-like protein
— OG7
LTRL590_360019900 ⚠
adenylate kinase, putative
— OG7
LTRL590_260015600 ⚠
hypothetical protein, conserved
— OG7
LTRL590_200016900 ⚠
phosphatidylinositol 3-kinase, putative
— OG7
LTRL590_300019100 ⚠
hypothetical protein, conserved
— OG7
LTRL590_130015000 ⚠
hypothetical protein, conserved
— OG7
LTRL590_080014300 ⚠
histone deacetylase, putative
— OG7
LTRL590_340047000 ⚠
GRIP domain containing protein, putative
— OG7
LTRL590_250008600 ⚠
RNA-binding protein, putative
— OG7
LTRL590_320020200 ⚠
RNA guanylyltransferase, putative
— OG7
LTRL590_340032900 ⚠
hypothetical protein, conserved
— OG7
LTRL590_360064100 ⚠
glycosyl hydrolase, putative
— OG7
LTRL590_350049500 ⚠
predicted zinc finger protein
— OG7
LTRL590_270013800 ⚠
parallel beta-helix repeat, putative
— OG7
LTRL590_320020600 ⚠
DEAD/DEAH box helicase-like protein, putative
— OG7
LTRL590_260005500 ⚠
FYVE zinc finger containing protein, putative
— OG7
LTRL590_340020700 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.