TCSYLVIO_010957

pyroglutamyl-peptidase I (PGP), putative,cysteine peptidase, Clan CF, family C15, putative
Trypanosoma cruzi Sylvio X10/1-2012 OG6: OG6_101530 OG7: OG7_0006024 Source organism 91 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
Cross-organism orthology
Defaulting to same-organism data. Applies on "Apply filters".
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Network view all shared interactors, plus up to 150 more
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Interactions 91 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TCSYLVIO_001008
mitochondrial DNA topoisomerase II, putative
T.cruzi_2025_Azimi Both
TCSYLVIO_004210
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_005185
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_009863
TPR-repeat-containing chaperone protein DNAJ,
T.cruzi_2025_Azimi — n/a
TCSYLVIO_007519
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_006151
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_002888
amino acid transporter, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_002375
C-1-tetrahydrofolate synthase, cytoplasmic, p
T.cruzi_2025_Azimi — n/a
TCSYLVIO_009716
serine/threonine protein kinase, putative,pro
T.cruzi_2025_Azimi — n/a
TCSYLVIO_004472
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_000361
nucleoside phosphorylase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_004898
nicotinate phosphoribosyltransferase, putativ
T.cruzi_2025_Azimi — n/a
TCSYLVIO_002651
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_001538
aspartate aminotransferase, mitochondrial, pu
T.cruzi_2025_Azimi — n/a
TCSYLVIO_004145
phosphomannose isomerase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_001147
GMP synthase, putative,glutamine amidotransfe
T.cruzi_2025_Azimi — n/a
TCSYLVIO_010946
isocitrate dehydrogenase [NADP], mitochondria
T.cruzi_2025_Azimi — n/a
TCSYLVIO_006262
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_002495
5'-3' exonuclease XRNA, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_000382
transcription elongation factor-like protein,
T.cruzi_2025_Azimi — n/a
TCSYLVIO_005923
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_001783
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_001508
aldo/keto reductase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_004414
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_001784
electron-transfer-flavoprotein, alpha polypep
T.cruzi_2025_Azimi — n/a
TCSYLVIO_003203
epsilon-adaptin, putative,AP-1/4 adapter comp
T.cruzi_2025_Azimi — n/a
TCSYLVIO_007658
6-phosphogluconolactonase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_002972
ubiquitin hydrolase, putative,cysteine peptid
T.cruzi_2025_Azimi — n/a
TCSYLVIO_008176
biotin/lipoate protein ligase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_010701
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_006856
hexokinase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_003074
2-hydroxy-3-oxopropionate reductase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_005716
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_001881
deoxyribose-phosphate aldolase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_010938
mitogen-activated protein kinase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_007974
phosphoglucomutase
T.cruzi_2025_Azimi — n/a
TCSYLVIO_002908
diphthine synthase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_005344
enoyl-CoA hydratase/isomerase family protein,
T.cruzi_2025_Azimi — n/a
TCSYLVIO_006405
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_004096
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_006876
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_006226
UTP-glucose-1-phosphate uridylyltransferase 2
T.cruzi_2025_Azimi — n/a
TCSYLVIO_005459
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_004608
2,3-bisphosphoglycerate-independent phosphogl
T.cruzi_2025_Azimi — n/a
TCSYLVIO_004765
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_008471
dihydroorotase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_004205
ubiquitin-conjugating enzyme protein, putativ
T.cruzi_2025_Azimi — n/a
TCSYLVIO_004300
carnitine/choline acetyltransferase, putative
T.cruzi_2025_Azimi — n/a
TCSYLVIO_007000
hypothetical protein
T.cruzi_2025_Azimi — n/a
TCSYLVIO_007482
protein phosphatase 2C, putative
T.cruzi_2025_Azimi — n/a
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.