TRSC58_02469

pyruvate kinase 2

Trypanosoma rangeli SC58 OG6: OG6_100258 OG7: OG7_0002165 184 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 184 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TRSC58_03555 acidocalcisomal pyrophosphatase	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
TRSC58_04993 hypothetical protein	—	OG6 TCSYLVIO_006133 ↔ TCSYLVIO_010611 OG6 Tb927.10.14140 ↔ Tb927.7.3770 OG7 Tb927.10.14140 ↔ Tb927.7.3770 OG7 TCSYLVIO_006133 ↔ TCSYLVIO_010611	Both
TRSC58_03224 ⚠ calpain-like cysteine peptidase	—	OG7 Tb927.10.14140 ↔ Tb927.9.7540	OG7
TRSC58_00117 ⚠ cAMP specific phosphodiesterase	—	OG6 Tb927.10.14140 ↔ Tb927.9.5040 OG7 Tb927.10.14140 ↔ Tb927.9.5040	Both
TRSC58_01059 ⚠ fatty acyl CoA syntetase 1	—	OG6 Tb927.10.14140 ↔ Tb927.9.4200 OG7 Tb927.10.14140 ↔ Tb927.9.4200	Both
TRSC58_06701 ⚠ glyceraldehyde 3-phosphate dehydrogenase	—	OG6 Tb927.10.14140 ↔ Tb927.10.6880 OG7 Tb927.10.14140 ↔ Tb927.9.9820 OG7 Tb927.10.14140 ↔ Tb927.10.6880	Both
TRSC58_05200 ⚠ hypothetical protein	—	OG6 Tb927.10.14140 ↔ Tb927.10.6880 OG7 Tb927.10.14140 ↔ Tb927.9.9820 OG7 Tb927.10.14140 ↔ Tb927.10.6880	Both
TRSC58_00504 ⚠ fatty acyl CoA syntetase 1	—	OG6 Tb927.10.14140 ↔ Tb927.9.4200 OG7 Tb927.10.14140 ↔ Tb927.9.4200	Both
TRSC58_02813 ⚠ glutaminyl-tRNA synthetase	—	OG6 Tb927.10.14140 ↔ Tb927.9.5210 OG7 Tb927.10.14140 ↔ Tb927.9.5210	Both
TRSC58_02197 guanine deaminase	—	OG6 Tb927.10.14140 ↔ Tb927.5.4560 OG7 Tb927.10.14140 ↔ Tb927.5.4560	Both
TRSC58_06909 ⚠ glyceraldehyde 3-phosphate dehydrogenase, cyt	—	OG6 Tb927.10.14140 ↔ Tb927.10.6880 OG7 Tb927.10.14140 ↔ Tb927.9.9820 OG7 Tb927.10.14140 ↔ Tb927.10.6880	Both
TRSC58_06402 ⚠ hypothetical protein	—	OG6 Tb927.10.14140 ↔ Tb927.10.6880 OG7 Tb927.10.14140 ↔ Tb927.9.9820 OG7 Tb927.10.14140 ↔ Tb927.10.6880	Both
TRSC58_04930 ⚠ NADH-dependent fumarate reductase	—	OG6 Tb927.10.14140 ↔ Tb927.5.930 OG7 Tb927.10.14140 ↔ Tb927.5.930	Both
TRSC58_05627 ⚠ fatty acyl CoA synthetase 2	—	OG6 Tb927.10.14140 ↔ Tb927.9.4200 OG7 Tb927.10.14140 ↔ Tb927.9.4200	Both
TRSC58_04716 ⚠ hypothetical protein	—	OG6 Tb927.10.14140 ↔ Tb927.7.4570 OG7 Tb927.10.14140 ↔ Tb927.7.4570	Both
TRSC58_02928 ⚠ aminopeptidase	—	OG6 Tb927.10.14140 ↔ Tb927.11.6590 OG7 Tb927.10.14140 ↔ Tb927.11.6590	Both
TRSC58_07121 ⚠ fatty acyl CoA synthetase	—	OG6 Tb927.10.14140 ↔ Tb927.9.4200 OG7 Tb927.10.14140 ↔ Tb927.9.4200	Both
TRSC58_04369 isovaleryl-coA dehydrogenase	—	OG6 Tb927.10.14140 ↔ Tb927.11.1540 OG7 Tb927.10.14140 ↔ Tb927.11.1540	Both
TRSC58_06554 ⚠ hypothetical protein	—	OG6 Tb927.10.14140 ↔ Tb927.10.6880 OG7 Tb927.10.14140 ↔ Tb927.9.9820 OG7 Tb927.10.14140 ↔ Tb927.10.6880	Both
TRSC58_06452 ⚠ glyceraldehyde 3-phosphate dehydrogenase, cyt	—	OG6 Tb927.10.14140 ↔ Tb927.10.6880 OG7 Tb927.10.14140 ↔ Tb927.9.9820 OG7 Tb927.10.14140 ↔ Tb927.10.6880	Both
TRSC58_00593 adenylosuccinate synthetase	—	OG6 Tb927.10.14140 ↔ Tb927.11.3650 OG7 Tb927.10.14140 ↔ Tb927.11.3650	Both
TRSC58_04280 S-adenosylmethionine synthetase	—	OG6 Tb927.10.14140 ↔ Tb927.6.4840 OG7 Tb927.10.14140 ↔ Tb927.6.4840	Both
TRSC58_06364 ⚠ glyceraldehyde 3-phosphate dehydrogenase	—	OG6 Tb927.10.14140 ↔ Tb927.10.6880 OG7 Tb927.10.14140 ↔ Tb927.9.9820 OG7 Tb927.10.14140 ↔ Tb927.10.6880	Both
TRSC58_00668 ⚠ glutaminyl-tRNA synthetase	—	OG6 Tb927.10.14140 ↔ Tb927.9.5210 OG7 Tb927.10.14140 ↔ Tb927.9.5210	Both
TRSC58_02117 transketolase	—	OG6 Tb927.10.14140 ↔ Tb927.8.6170 OG7 Tb927.10.14140 ↔ Tb927.8.6170	Both
TRSC58_00092 ⚠ hypothetical protein	—	OG6 Tb927.10.14140 ↔ Tb927.5.930 OG7 Tb927.10.14140 ↔ Tb927.5.930	Both
TRSC58_03759 ⚠ dihydrofolate reductase-thymidylate synthase	—	OG6 Tb927.10.14140 ↔ Tb927.7.5480 OG7 Tb927.10.14140 ↔ Tb927.7.5480	Both
TRSC58_03666 phosphomannomutase-like protein	—	OG6 TCSYLVIO_003734 ↔ TCSYLVIO_006133 OG7 TCSYLVIO_003734 ↔ TCSYLVIO_006133	Both
TRSC58_01208 N-myristoyl transferase	—	OG6 TCSYLVIO_006126 ↔ TCSYLVIO_006133 OG7 TCSYLVIO_006126 ↔ TCSYLVIO_006133	Both
TRSC58_06291 ubiquitin hydrolase	—	OG6 TCSYLVIO_002972 ↔ TCSYLVIO_006133 OG7 TCSYLVIO_002972 ↔ TCSYLVIO_006133	Both
TRSC58_06350 ⚠ amidohydrolase	—	OG6 Tb927.1.3000 ↔ Tb927.10.14140 OG7 Tb927.1.3000 ↔ Tb927.10.14140	Both
TRSC58_02525 hypothetical protein	—	OG6 TCSYLVIO_002651 ↔ TCSYLVIO_006133 OG7 TCSYLVIO_002651 ↔ TCSYLVIO_006133	Both
TRSC58_02594 hypothetical protein	—	OG6 TCSYLVIO_004414 ↔ TCSYLVIO_006133 OG7 TCSYLVIO_004414 ↔ TCSYLVIO_006133	Both
TRSC58_05892 ⚠ amidohydrolase	—	OG6 Tb927.1.3000 ↔ Tb927.10.14140 OG7 Tb927.1.3000 ↔ Tb927.10.14140	Both
TRSC58_02403 ⚠ aminoacylase	—	OG6 Tb927.1.3000 ↔ Tb927.10.14140 OG7 Tb927.1.3000 ↔ Tb927.10.14140	Both
TRSC58_06861 ⚠ amidohydrolase	—	OG6 Tb927.1.3000 ↔ Tb927.10.14140 OG7 Tb927.1.3000 ↔ Tb927.10.14140	Both
TRSC58_05656 nicotinate phosphoribosyltransferase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006133 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006133	Both
TRSC58_05901 35 kDa cyclophilin	—	OG6 TCSYLVIO_003462 ↔ TCSYLVIO_006133	OG6
TRSC58_03188 ⚠ transcription elongation factor-like protein	—	OG6 TCSYLVIO_000382 ↔ TCSYLVIO_006133 OG7 TCSYLVIO_000382 ↔ TCSYLVIO_006133	Both
TRSC58_01227 glucose-6-phosphate isomerase, glycosomal	—	OG6 Tb927.1.3830 ↔ Tb927.10.14140 OG7 Tb927.1.3830 ↔ Tb927.10.14140	Both
TRSC58_00152 deoxyribose-phosphate aldolase	—	OG6 TCSYLVIO_001881 ↔ TCSYLVIO_006133 OG7 TCSYLVIO_001881 ↔ TCSYLVIO_006133	Both
TRSC58_06101 ⚠ MCAK-like kinesin	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_006133	OG7
TRSC58_06570 ⚠ kinesin family member 2/24	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_006133	OG7
TRSC58_04165 ⚠ MCAK-like kinesin	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_006133	OG7
TRSC58_04721 ⚠ hypothetical protein	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_006133	OG7
TRSC58_06191 ⚠ mitotic centromere-associated kinesin (MCAK)	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_006133	OG7
TRSC58_05649 ⚠ calpain cysteine peptidase	—	OG7 Tb927.10.14140 ↔ Tb927.9.7540	OG7
TRSC58_02091 ⚠ stress-induced protein sti1	—	OG7 TCSYLVIO_006133 ↔ TCSYLVIO_009926	OG7
TRSC58_02568 methylenetetrahydrofolate dehydrogenase-like	—	OG7 TCSYLVIO_002375 ↔ TCSYLVIO_006133	OG7
TRSC58_01909 ⚠ elongation factor G2-like protein	—	OG7 TCSYLVIO_006133 ↔ TCSYLVIO_007487	OG7

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