TRSC58_05489

delta-1-pyrroline-5-carboxylate dehydrogenase

Trypanosoma rangeli SC58 OG6: OG6_102275 OG7: OG7_0000710 46 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 46 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TRSC58_04568 ⚠ mitochondrial tryparedoxin peroxidase, trypan	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
TRSC58_02929 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 Tb927.10.3210 ↔ Tb927.10.9430 OG6 Tb927.10.3210 ↔ Tb927.11.3030 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 +2 more	Both
TRSC58_00774 ATP synthase	—	OG6 Tb927.10.3210 ↔ Tb927.10.730 OG7 Tb927.10.3210 ↔ Tb927.10.730	Both
TRSC58_06238 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 OG7 Tb927.10.3210 ↔ Tb927.11.3030 +1 more	Both
TRSC58_00246 vacuolar ATP synthase subunit B	—	OG6 Tb927.10.3210 ↔ Tb927.11.11690 OG7 Tb927.10.3210 ↔ Tb927.11.11690	Both
TRSC58_06401 ⚠ acetyl-CoA carboxylase	—	OG6 Tb927.10.3210 ↔ Tb927.8.7100 OG7 Tb927.10.3210 ↔ Tb927.8.7100	Both
TRSC58_04952 ⚠ ribose-phosphate pyrophosphokinase	—	OG6 Tb927.10.3210 ↔ Tb927.5.3170 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 OG7 Tb927.10.3210 ↔ Tb927.11.3030 +1 more	Both
TRSC58_06069 V-type ATPase, A subunit	—	OG6 Tb927.10.3210 ↔ Tb927.4.1080 OG7 Tb927.10.3210 ↔ Tb927.4.1080	Both
TRSC58_04558 3-methylcrotonoyl-CoA carboxylase beta subuni	—	OG6 Tb927.10.3210 ↔ Tb927.11.6630 OG7 Tb927.10.3210 ↔ Tb927.11.6630	Both
TRSC58_02439 ⚠ hypothetical protein	—	OG6 Tb927.10.3210 ↔ Tb927.8.7100 OG7 Tb927.10.3210 ↔ Tb927.8.7100	Both
TRSC58_06266 pyruvate phosphate dikinase	—	OG6 Tb927.10.3210 ↔ Tb927.11.6280 OG7 Tb927.10.3210 ↔ Tb927.11.6280	Both
TRSC58_03167 ATP synthase	—	OG6 Tb927.10.3210 ↔ Tb927.11.9420 OG7 Tb927.10.3210 ↔ Tb927.11.9420	Both
TRSC58_05800 (H+)-ATPase G subunit	—	OG6 Tb927.10.3210 ↔ Tb927.8.2310 OG7 Tb927.10.3210 ↔ Tb927.8.2310	Both
TRSC58_04392 ⚠ hypothetical protein	—	OG6 Tb927.10.3210 ↔ Tb927.10.9430 OG6 Tb927.10.3210 ↔ Tb927.11.3030 OG7 Tb927.10.3210 ↔ Tb927.5.2960 OG7 Tb927.10.3210 ↔ Tb927.10.9430 +2 more	Both
TRSC58_02563 ⚠ tryparedoxin peroxidase	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
TRSC58_06404 ⚠ hypothetical protein	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_004515	Both
TRSC58_04722 ⚠ hypothetical protein	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_004515	Both
TRSC58_04634 ATP synthase subunit	—	OG6 Tb927.1.3820 ↔ Tb927.10.3210 OG7 Tb927.1.3820 ↔ Tb927.10.3210	Both
TRSC58_01864 ⚠ hexokinase	—	OG6 Tb927.10.2010 ↔ Tb927.10.3210 OG6 Tb927.10.2020 ↔ Tb927.10.3210 OG7 Tb927.10.2010 ↔ Tb927.10.3210 OG7 Tb927.10.2020 ↔ Tb927.10.3210	Both
TRSC58_03752 ⚠ hexokinase	—	OG6 Tb927.10.2010 ↔ Tb927.10.3210 OG6 Tb927.10.2020 ↔ Tb927.10.3210 OG7 Tb927.10.2010 ↔ Tb927.10.3210 OG7 Tb927.10.2020 ↔ Tb927.10.3210	Both
TRSC58_06901 ⚠ hexokinase	—	OG6 Tb927.10.2010 ↔ Tb927.10.3210 OG6 Tb927.10.2020 ↔ Tb927.10.3210 OG7 Tb927.10.2010 ↔ Tb927.10.3210 OG7 Tb927.10.2020 ↔ Tb927.10.3210	Both
TRSC58_05371 ⚠ prolyl oligopeptidase	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
TRSC58_05012 ⚠ prolyl oligopeptidase	—	OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	OG7
TRSC58_07179 ⚠ peptidase	—	OG6 TCSYLVIO_002764 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_002764 ↔ TCSYLVIO_004515	Both
TRSC58_04560 ⚠ deoxyhypusine synthase	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_007258	Both
TRSC58_06894 ⚠ hypothetical protein	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005818 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005818	Both
TRSC58_00528 ⚠ deoxyhypusine synthase	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_007258 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_007258	Both
TRSC58_02133 glycyl-tRNA synthetase	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_009222 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_009222	Both
TRSC58_04010 ⚠ Oligopeptidase B	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_006546 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	Both
TRSC58_03665 hypothetical protein	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005125 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005125	Both
TRSC58_00793 ⚠ oligopeptidase B-like protein	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_006546 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_006546	Both
TRSC58_05756 hypothetical protein	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005080 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005080	Both
TRSC58_04190 ⚠ hypothetical protein	—	OG6 TCSYLVIO_003345 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003345 ↔ TCSYLVIO_004515	Both
TRSC58_07059 ⚠ valyl-tRNA synthetase	—	OG6 TCSYLVIO_003345 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003345 ↔ TCSYLVIO_004515	Both
TRSC58_03936 ⚠ valyl-tRNA synthetase	—	OG6 TCSYLVIO_003345 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003345 ↔ TCSYLVIO_004515	Both
TRSC58_04627 ⚠ hypothetical protein	—	OG6 TCSYLVIO_004515 ↔ TCSYLVIO_005818 OG7 TCSYLVIO_004515 ↔ TCSYLVIO_005818	Both
TRSC58_00141 ⚠ peptidase	—	OG6 TCSYLVIO_002764 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_002764 ↔ TCSYLVIO_004515	Both
TRSC58_04454 ⚠ leucyl-tRNA synthetase	—	OG6 TCSYLVIO_003028 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_004515	Both
TRSC58_00909 ⚠ leucyl-tRNA synthetase	—	OG6 TCSYLVIO_003028 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_004515	Both
TRSC58_04621 hypothetical protein	—	OG6 TCSYLVIO_003373 ↔ TCSYLVIO_004515 OG7 TCSYLVIO_003373 ↔ TCSYLVIO_004515	Both
TRSC58_04773 serine/threonine protein kinase	—	OG6 TCSYLVIO_004423 ↔ TCSYLVIO_004515	OG6
TRSC58_04750 ⚠ 2-oxoisovalerate dehydrogenase beta subunit,	—	OG6 Tb927.10.3210 ↔ Tb927.10.4330 OG7 Tb927.10.3210 ↔ Tb927.10.4330	Both
TRSC58_06864 ⚠ 2-oxoisovalerate dehydrogenase beta subunit,	—	OG6 Tb927.10.3210 ↔ Tb927.10.4330 OG7 Tb927.10.3210 ↔ Tb927.10.4330	Both
TRSC58_02390 ⚠ acetyl-CoA carboxylase	—	OG6 Tb927.10.3210 ↔ Tb927.8.7100 OG7 Tb927.10.3210 ↔ Tb927.8.7100	Both
TRSC58_06481 ⚠ mitochondrial tryparedoxin peroxidase	—	OG6 Tb927.10.3210 ↔ Tb927.8.1990 OG7 Tb927.10.3210 ↔ Tb927.8.1990	Both
TRSC58_04758 S-adenosylhomocysteine hydrolase	—	OG6 Tb927.10.3210 ↔ Tb927.11.9590 OG7 Tb927.10.3210 ↔ Tb927.11.9590	Both