TcYC6_0083800

3-hydroxy-3-methylglutaryl-CoA synthase, putative
Trypanosoma cruzi Y C6 OG6: OG6_101064 OG7: OG7_0006553 103 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 103 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0012450 ⚠
Small Surface Antigen
— OG7
TcYC6_0044880 ⚠
serine sulfhydrylase
— Both
TcYC6_0044910 ⚠
serine sulfhydrylase
— Both
TcYC6_0044440 ⚠
serine sulfhydrylase
— Both
TcYC6_0175670 ⚠
hypothetical protein
— Both
TcYC6_0044890 ⚠
serine sulfhydrylase
— Both
TcYC6_0046320 ⚠
serine sulfhydrylase
— Both
TcYC6_0044900 ⚠
serine sulfhydrylase
— Both
TcYC6_0044870 ⚠
serine sulfhydrylase
— Both
TcYC6_0128170 ⚠
serine sulfhydrylase
— Both
TcYC6_0006570 ⚠
cysteine synthase, putative
— OG6
TcYC6_0050610
Nucleoside diphosphate kinase 1
— Both
TcYC6_0031010 ⚠
3-ketoacyl-CoA thiolase, putative
— Both
TcYC6_0028110 ⚠
tryparedoxin peroxidase, putative
— Both
TcYC6_0028130 ⚠
tryparedoxin peroxidase, putative
— Both
TcYC6_0032470 ⚠
peroxidoxin
— Both
TcYC6_0028100 ⚠
tryparedoxin peroxidase, putative
— Both
TcYC6_0028120 ⚠
tryparedoxin peroxidase, putative
— Both
TcYC6_0064250
hypothetical protein, conserved
— Both
TcYC6_0110280 ⚠
Fumarate hydratase class I, cytosolic
— Both
TcYC6_0081230 ⚠
fumarate hydratase, putative
— Both
TcYC6_0017390
cytidine triphosphate synthase, putative
— Both
TcYC6_0099250 ⚠
putative nonspecific lipid-transfer protein
— OG7
TcYC6_0097620 ⚠
leucyl/phenylalanyl-tRNA protein transferase,
— OG7
TcYC6_0079830 ⚠
SNF1-related protein kinase, putative
— OG7
TcYC6_0014130 ⚠
ATP-dependent RNA helicase FAL1, putative
— OG7
TcYC6_0073300 ⚠
choline kinase
— OG7
TcYC6_0051670 ⚠
small nuclear ribonucleoprotein component
— OG7
TcYC6_0119810 ⚠
translation elongation factor EF-2, putative
— OG7
TcYC6_0121410 ⚠
nuclear lim interactor-interacting factor, pu
— OG7
TcYC6_0125080 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
TcYC6_0068670 ⚠
TFIIF-stimulated CTD phosphatase, putative
— OG7
TcYC6_0110800 ⚠
NLI interacting factor-like phosphatase, puta
— OG7
TcYC6_0110330 ⚠
NOL1/NOP2/sun family, putative
— OG7
TcYC6_0014080 ⚠
NOL1/NOP2/sun family, putative
— OG7
TcYC6_0046610 ⚠
TFIIF-stimulated CTD phosphatase, putative
— OG7
TcYC6_0119750 ⚠
mitochondrial import inner membrane transloca
— OG7
TcYC6_0051270 ⚠
NOL1/NOP2/sun family, putative
— OG7
TcYC6_0107640 ⚠
nucleolar protein, putative
— OG7
TcYC6_0084140 ⚠
Eukaryotic initiation factor 4A-1
— OG7
TcYC6_0093270 ⚠
calcium/calmodulin-dependent protein kinase,
— OG7
TcYC6_0078640 ⚠
CAMK/CAMKL family protein kinase, putative
— OG7
TcYC6_0175560 ⚠
ATP-dependent DEAD/H RNA helicase, putative
— OG7
TcYC6_0110350 ⚠
5'-AMP-activated protein kinase catalytic sub
— OG7
TcYC6_0009920 ⚠
CAMK/CAMKL pseudokinase, putative
— OG7
TcYC6_0046790 ⚠
CAMK/CAMKL family protein kinase, putative
— OG7
TcYC6_0102720 ⚠
aminopeptidase
— OG7
TcYC6_0044200 ⚠
Calcium/calmodulin-dependent protein kinase k
— OG7
TcYC6_0044210 ⚠
Calcium/calmodulin-dependent protein kinase k
— OG7
TcYC6_0042400
methylthioadenosine phosphorylase, putative
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.