C4B63_18g204

3-hydroxy-3-methylglutaryl-CoA reductase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101762 OG7: OG7_0005934 20 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 20 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_134g60 ⚠
aspartate carbamoyltransferase
— Both
C4B63_40g105 ⚠
apurinic/apyrimidinic endonuclease
— OG7
C4B63_22g179 ⚠
conserved hypothetical protein
— OG7
C4B63_335g1 ⚠
conserved hypothetical protein
— OG7
C4B63_23g76
ubiquitin carboxyl-terminal hydrolase
— Both
C4B63_23g75
enoyl-CoA hydratase, mitochondrial precursor
— Both
C4B63_8g479
conserved hypothetical protein
— Both
C4B63_2g752
6-phosphogluconate dehydrogenase, decarboxyla
— Both
C4B63_35g108 ⚠
apurinic/apyrimidinic endonuclease
— Both
C4B63_303g16 ⚠
trypanothione reductase
— Both
C4B63_4g184
citrate synthase
— Both
C4B63_35g155 ⚠
aspartate carbamoyltransferase
— Both
C4B63_60g116 ⚠
aspartate carbamoyltransferase
— Both
C4B63_14g241 ⚠
trypanothione reductase
— Both
C4B63_31g264 ⚠
aspartate carbamoyltransferase
— Both
C4B63_31g115
eukaryotic translation initiation factor 2 be
— Both
C4B63_2g558
eukaryotic peptide chain release factor subun
— Both
C4B63_14g200
conserved hypothetical protein
— Both
C4B63_11g93
mitochondrial RNA binding complex 1 subunit
— Both
C4B63_45g210
pre-rrna-processing protein tsr1 homolog
— Both
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.