C4B63_81g41

Suppressor of disruption of TFIIS
Trypanosoma cruzi Dm28c 2018 OG6: OG6_106165 OG7: OG7_0009984 71 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 71 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_12g222
inositol-1,4,5-trisphosphate (IP3) 5-phosphat
— Both
C4B63_163g32 ⚠
rac serine-threonine kinase
— OG6
C4B63_267g13 ⚠
Nuclear protein localization protein 4 homolo
— Both
C4B63_47g50
conserved hypothetical protein
— Both
C4B63_286g15 ⚠
PSP1 C-terminal conserved region
— OG6
C4B63_63g4 ⚠
PSP1 C-terminal conserved region
— OG6
C4B63_111g26 ⚠
cell cycle sequence binding phosphoprotein (R
— OG6
C4B63_70g68 ⚠
cell cycle sequence binding phosphoprotein (R
— OG6
C4B63_338g16 ⚠
cell cycle sequence binding phosphoprotein (R
— OG6
C4B63_12g315 ⚠
Nuclear protein localization protein 4 homolo
— Both
C4B63_39g341
conserved hypothetical protein
— Both
C4B63_19g244
Dynein assembly factor 3, axonemal
— Both
C4B63_38g56
conserved hypothetical protein
— Both
C4B63_2g363
conserved hypothetical protein
— Both
C4B63_2g355
conserved hypothetical protein
— Both
C4B63_61g129
conserved hypothetical protein
— Both
C4B63_27g188
conserved hypothetical protein
— Both
C4B63_1g68
Intraflagellar transport protein 25
— Both
C4B63_14g48 ⚠
rab-like GTPase activating protein
— OG7
C4B63_24g178
conserved hypothetical protein
— OG7
C4B63_112g13 ⚠
neurobeachin/beige-like protein(fragment)
— OG7
C4B63_48g122 ⚠
neurobeachin/beige protein
— OG7
C4B63_48g123 ⚠
neurobeachin/beige protein
— OG7
C4B63_48g124 ⚠
neurobeachin/beige protein
— OG7
C4B63_112g14 ⚠
neurobeachin/beige-like protein
— OG7
C4B63_27g9 ⚠
conserved hypothetical protein
— OG7
C4B63_122g26 ⚠
conserved hypothetical protein
— OG7
C4B63_8g560 ⚠
Adenine phosphoribosyltransferase
— Both
C4B63_42g216 ⚠
disgorgin
— OG7
C4B63_56g46 ⚠
ATP-dependent RNA helicase
— OG7
C4B63_19g43 ⚠
1,2-Dihydroxy-3-keto-5-methylthiopentene diox
— OG7
C4B63_9g383 ⚠
conserved hypothetical protein
— OG7
C4B63_28g77
conserved hypothetical protein
— Both
C4B63_16g91
Bis(5'-adenosyl)-triphosphatase
— Both
C4B63_6g430
conserved hypothetical protein
— Both
C4B63_30g274 ⚠
rac serine-threonine kinase
— OG6
C4B63_275g16 ⚠
ras-related GTP-binding protein
— OG6
C4B63_14g37
conserved hypothetical protein
— Both
C4B63_14g192 ⚠
PSP1 C-terminal conserved region
— OG6
C4B63_132g66 ⚠
NUDIX hydrolase 3
— Both
C4B63_14g50 ⚠
disgorgin
— Both
C4B63_14g175 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— Both
C4B63_39g304 ⚠
NUDIX hydrolase 3
— Both
C4B63_14g193 ⚠
PSP1 C-terminal conserved region
— OG6
C4B63_14g176 ⚠
ATP-dependent DEAD/H RNA helicase
— Both
C4B63_18g208
conserved hypothetical protein
— Both
C4B63_8g463
conserved hypothetical protein
— Both
C4B63_122g3 ⚠
ras-related GTP-binding protein
— OG6
C4B63_51g209 ⚠
nucleoside 2-deoxyribosyltransferase
— Both
C4B63_361g14 ⚠
nucleoside 2-deoxyribosyltransferase
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.