C4B63_19g43

1,2-Dihydroxy-3-keto-5-methylthiopentene dioxygenase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_139725 OG7: OG7_0005923 60 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 60 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_8g559 ⚠
Adenine phosphoribosyltransferase
— Both
C4B63_8g560 ⚠
Adenine phosphoribosyltransferase
— Both
C4B63_2g524 ⚠
Charged multivesicular body protein 3
— OG7
C4B63_26g269 ⚠
PTP1-interacting protein, 39 kDa
— OG7
C4B63_8g463 ⚠
conserved hypothetical protein
— OG7
C4B63_81g41 ⚠
Suppressor of disruption of TFIIS
— OG7
C4B63_297g19 ⚠
Protein phosphatase methylesterase 1
— OG7
C4B63_83g24 ⚠
zinc-finger (CCCH type) protein
— OG7
C4B63_39g304 ⚠
NUDIX hydrolase 3
— OG7
C4B63_20g305 ⚠
Uncharacterized protein C9orf85 homolog
— OG7
C4B63_42g216 ⚠
disgorgin
— OG7
C4B63_14g48 ⚠
rab-like GTPase activating protein
— OG7
C4B63_361g14 ⚠
nucleoside 2-deoxyribosyltransferase
— OG7
C4B63_95g67 ⚠
nucleoside 2-deoxyribosyltransferase
— OG7
C4B63_17g73 ⚠
Probable protein phosphatase methylesterase 1
— OG7
C4B63_9g383 ⚠
conserved hypothetical protein
— OG7
C4B63_132g66 ⚠
NUDIX hydrolase 3
— OG7
C4B63_28g77 ⚠
conserved hypothetical protein
— OG7
C4B63_279g8 ⚠
ubiquitin carboxyl-terminal hydrolase
— Both
C4B63_14g37 ⚠
conserved hypothetical protein
— OG7
C4B63_397g11 ⚠
zinc-finger CCCH domain containing protein 11
— OG7
C4B63_18g169 ⚠
Zinc finger CCCH domain-containing protein 47
— OG7
C4B63_40g21 ⚠
Charged multivesicular body protein 3
— OG7
C4B63_51g209 ⚠
nucleoside 2-deoxyribosyltransferase
— OG7
C4B63_12g2035c ⚠
zinc-finger protein 2
— OG7
C4B63_9g382 ⚠
conserved hypothetical protein
— OG7
C4B63_15g5 ⚠
zinc-finger CCCH domain containing protein 11
— OG7
C4B63_21g80 ⚠
conserved hypothetical protein
— OG7
C4B63_54g18 ⚠
serine palmitoyltransferase
— OG7
C4B63_7g356 ⚠
serine-palmitoyl-CoA transferase
— OG7
C4B63_18g313 ⚠
conserved hypothetical protein
— OG7
C4B63_145g3 ⚠
NADP-dependent alcohol hydrogenase
— Both
C4B63_31g85 ⚠
iron superoxide dismutase A, mitochondrial
— Both
C4B63_80g53 ⚠
iron superoxide dismutase
— Both
C4B63_392g17 ⚠
iron superoxide dismutase
— Both
C4B63_148g27 ⚠
iron superoxide dismutase
— Both
C4B63_17g233 ⚠
iron superoxide dismutase
— Both
C4B63_150g37 ⚠
short chain 3-hydroxyacyl-CoA dehydrogenase
— Both
C4B63_57g66 ⚠
short chain 3-hydroxyacyl-CoA dehydrogenase
— Both
C4B63_9g516 ⚠
heat shock protein Hsp20
— Both
C4B63_82g107 ⚠
NADP-dependent alcohol hydrogenase
— Both
C4B63_82g121 ⚠
NADP-dependent alcohol hydrogenase
— Both
C4B63_145g28 ⚠
NADP-dependent alcohol hydrogenase
— Both
C4B63_145g18 ⚠
NADP-dependent alcohol hydrogenase
— Both
C4B63_77g46 ⚠
NADP-dependent alcohol hydrogenase
— Both
C4B63_77g74 ⚠
NADP-dependent alcohol hydrogenase
— Both
C4B63_14g50 ⚠
disgorgin
— OG7
C4B63_32g236 ⚠
transketolase
— Both
C4B63_4g137 ⚠
N-myristoyl transferase
— Both
C4B63_4g462 ⚠
arginase
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.