LAEL147_000706200

eukaryotic translation initiation factor 5, putative

Leishmania aethiopica L147 OG6: OG6_101859 OG7: OG7_0007078 58 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Query Computational only Exp + computational Experimental only

Interactions 58 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
LAEL147_000456200 ⚠ proteasome alpha 7 subunit, putative	—	OG7 TCSYLVIO_001707 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_009369	OG7
LAEL147_000868200 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 TCSYLVIO_004556 ↔ TCSYLVIO_004731 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_004731	Both
LAEL147_000686900 ⚠ phosphoribosylpyrophosphate synthetase, putat	—	OG6 TCSYLVIO_004556 ↔ TCSYLVIO_004731 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_004731	Both
LAEL147_000821300 N-acetyltransferase subunit Nat1, putative	—	OG6 TCSYLVIO_004556 ↔ TCSYLVIO_010020 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_010020	Both
LAEL147_000773000 ATP-dependent RNA helicase-like protein	—	OG6 TCSYLVIO_001373 ↔ TCSYLVIO_004556	OG6
LAEL147_000578900 eukaryotic translation initiation factor 3 su	—	OG6 TCSYLVIO_003333 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_003333 ↔ TCSYLVIO_004556	Both
LAEL147_000618400 acetyl-CoA carboxylase, putative	—	OG6 TCSYLVIO_002772 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_002772 ↔ TCSYLVIO_004556	Both
LAEL147_000482400 proteasome beta 3 subunit, putative	—	OG6 TCSYLVIO_001736 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_001736 ↔ TCSYLVIO_004556	Both
LAEL147_000006000 ⚠ proteasome alpha 7 subunit, putative	—	OG6 TCSYLVIO_001707 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_009369	Both
LAEL147_000148500 ⚠ proteasome alpha 7 subunit, putative	—	OG6 TCSYLVIO_001707 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_009369 OG7 TCSYLVIO_001707 ↔ TCSYLVIO_004556	Both
LAEL147_000886200 ⚠ T-complex protein 1, theta subunit, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_008271	OG7
LAEL147_000790500 ⚠ T-complex protein 1, eta subunit, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_008271	OG7
LAEL147_000467800 ⚠ T-complex protein 1, beta subunit, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_008271	OG7
LAEL147_000189200 ⚠ chaperonin TCP20, putative	—	OG7 TCSYLVIO_000177 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_008271	OG7
LAEL147_000841800 ⚠ ATP-dependent RNA helicase, putative	—	OG7 TCSYLVIO_004479 ↔ TCSYLVIO_004556	OG7
LAEL147_000850300 60S ribosomal protein L10a, putative	—	OG6 TCSYLVIO_004556 ↔ TCSYLVIO_006190 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_006190	Both
LAEL147_000824800 ⚠ proteasome alpha 1 subunit, putative	—	OG7 TCSYLVIO_001707 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_009369	OG7
LAEL147_000333600 ⚠ proteasome subunit alpha type-5, putative	—	OG7 TCSYLVIO_001707 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_009369	OG7
LAEL147_000193200 ⚠ proteasome alpha 3 subunit, putative	—	OG7 TCSYLVIO_001707 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005678 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_009369	OG7
LAEL147_000831400 ⚠ DEAD box RNA helicase, putative	—	OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005835	OG7
LAEL147_000090900 ⚠ ATP-dependent DEAD/H RNA helicase, putative	—	OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005835	OG7
LAEL147_000101700 ⚠ ATP-dependent DEAD/H RNA helicase, putative	—	OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005835	OG7
LAEL147_000278000 ⚠ RNA binding protein, putative	—	OG7 TCSYLVIO_004556 ↔ TCSYLVIO_006059	OG7
LAEL147_000504400 ⚠ mitochondrial DEAD box protein, putative	—	OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005835	OG7
LAEL147_000131900 ⚠ DEAD/DEAH box helicase, putative	—	OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005835	OG7
LAEL147_000825400 ⚠ proteasome beta 5 subunit, putative	—	OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_006999	OG7
LAEL147_000106200 ⚠ ribose-phosphate pyrophosphokinase, putative	—	OG7 TCSYLVIO_004556 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_004731	OG7
LAEL147_000625000 ⚠ ATP-dependent RNA helicase, putative	—	OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005835	OG7
LAEL147_000090800 ⚠ hypothetical protein	—	OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005835	OG7
LAEL147_000782300 ⚠ ATP-dependent RNA helicase, putative	—	OG6 TCSYLVIO_004556 ↔ TCSYLVIO_005835 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005835	Both
LAEL147_000729700 RNA recognition motif. (a.k.a. RRM, RBD, or R	—	OG6 TCSYLVIO_003837 ↔ TCSYLVIO_004556	OG6
LAEL147_000862900 hypothetical protein, conserved	—	OG6 Tb927.10.2770 ↔ Tb927.11.11010 OG7 Tb927.10.2770 ↔ Tb927.11.11010	Both
LAEL147_000653600 ⚠ ATP binding protein-like protein	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_004556	Both
LAEL147_000477600 ⚠ Thioredoxin, putative	—	OG6 TCSYLVIO_000453 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_000453 ↔ TCSYLVIO_004556	Both
LAEL147_000552300 spliceosome-associated protein, putative	—	OG6 TCSYLVIO_003119 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_003119 ↔ TCSYLVIO_004556	Both
LAEL147_000042900 ⚠ DEAD/DEAH box helicase, putative	—	OG6 TCSYLVIO_004479 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004479 ↔ TCSYLVIO_004556	Both
LAEL147_000734200 exosome subunit rrp6p homologue, putative	—	OG6 TCSYLVIO_003804 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_003804 ↔ TCSYLVIO_004556	Both
LAEL147_000659300 ⚠ exosome-associated protein 2, putative	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004556	Both
LAEL147_000349200 ⚠ exosome complex exonuclease RRP45 homolog, pu	—	OG6 TCSYLVIO_001893 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_001893 ↔ TCSYLVIO_004556	Both
LAEL147_000006200 hypothetical protein, conserved	—	OG6 TCSYLVIO_001704 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_001704 ↔ TCSYLVIO_004556	Both
LAEL147_000631900 ⚠ chaperonin containing t-complex protein, puta	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_008271	Both
LAEL147_000367300 ⚠ T-complex protein 1, gamma subunit, putative	—	OG6 TCSYLVIO_000177 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_000177 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005312 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_008271	Both
LAEL147_000037100 acetyltransferase, putative	—	OG6 TCSYLVIO_004519 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004519 ↔ TCSYLVIO_004556	Both
LAEL147_000097400 splicing factor ptsr1-like protein	—	OG6 TCSYLVIO_004556 ↔ TCSYLVIO_009720 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_009720	Both
LAEL147_000531100 hypothetical protein, conserved	—	OG6 TCSYLVIO_004312 ↔ TCSYLVIO_004556 OG7 TCSYLVIO_004312 ↔ TCSYLVIO_004556	Both
LAEL147_000847100 ⚠ 2-oxoglutarate dehydrogenase subunit, putativ	—	OG6 TCSYLVIO_004556 ↔ TCSYLVIO_005469 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005469	Both
LAEL147_000198800 hypothetical protein	—	OG6 TCSYLVIO_004556 ↔ TCSYLVIO_008440	OG6
LAEL147_000463900 ⚠ 2-oxoglutarate dehydrogenase subunit, putativ	—	OG6 TCSYLVIO_004556 ↔ TCSYLVIO_005469 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005469	Both
LAEL147_000162000 ⚠ proteasome beta-1 subunit, putative	—	OG6 TCSYLVIO_004556 ↔ TCSYLVIO_006999 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_005774 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_006999	Both
LAEL147_000111300 ⚠ phosphoribosylpyrophosphate synthetase	—	OG6 TCSYLVIO_004556 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_010787 OG7 TCSYLVIO_004556 ↔ TCSYLVIO_004731	Both

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